Description : Which of the following suggests a diagnosis of familial combined hyperlipidaemia (FCHL) rather than heterozygous familial hypercholesterolaemia (FH)? 1) Tendon xanthomas 2) Presence of glucose ... premature coronary artery disease 4) Presence of arcus senilus 5) Absence of hyperuricaemia
Last Answer : Answers-2 The genetic dislipidaemias occur in one third of patients who have suffered from their first myocardial infarction below the age of 50 years in men. The commonest is familial combined ... xanthomata and arcus cornea are rarely present in children, but are very important signs to identify.
Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas
Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.
Description : Genetic deficiency of lipoprotein lipase causes hyperlipoproteinaemia of following type: (A) Type I (B) Type IIa (C) Type IIb (D) Type V
Last Answer : Answer : A
Description : An important zinc containing enzyme is (A) Carboxypeptidase A (B) Isocitrate dehydrogenase (C) Cholinesterate (D) Lipoprotein lipase
Description : ‘Clearing factor’ is (A) Lipoprotein lipase (B) Crotonase (C) 7-dehydro cholesterol (D) β-sitosterol
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : A non-functional plasma enzyme is (A) Psudocholinesterase (B) Lipoprotein lipase (C) Proenzyme of blood coagulation (D) Lipase
Last Answer : Answer : D
Description : An example of functional plasma enzyme is (A) Lipoprotein lipase (B) Amylase (C) Aminotransferase (D) Lactate dehydrogenase
Description : Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase
Last Answer : Answer : B
Description : This interferes with cholesterol absorption (A) Lipoprotein lipase (B) Creatinase (C) 7-dehydrocholesterol (D) β-sitosterol
Description : The triacyl glycerol present in plasma lipoproteins are hydrolyzed by (A) Linqual lipase (B) Pancreatic lipase (C) Colipase (D) Lipoprotein lipase
Description : Apolipoprotein C-II is an activator of (A) Lecithin cholesterola acyl transferase (B) Phospholipase C (C) Extrahepatic lipoprotein lipase (D) Hepatic lipoprotein lipase
Last Answer : Answer : C
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : Free fatty acids are transported in the blood (A) Combined with albumin (B) Combined with fatty acid binding protein (C) Combined with β -lipoprotein (D) In unbound free salts
Description : A 65-year old patient has colon carcinoma metastatic to the liver and lungs. He has had a weight loss of 10 kg. Cytokine-dependent tumor cachexia is attributable to which of the ... is impaired e. Partial reversal of differentiated adipocytes to pre-adipocyte morphology and gene expression occurs
Last Answer : Answer: a, b, c, d, e Tumor cachexia appears to be mediated by TNFa. Lipopolysaccharide (LPS), as well as other cytokines, activate a variety of inflammatory cells, most ... chronic syndromes of anorexia, weight loss, and cachexia that are associated with both chronic infection and malignancy
Description : Six months after beginning atorvastatin, the patient's total and LDL cholesterol concentrations remained above normal and he continued to have anginal attacks despite good adherence to his antianginal ... Increased endocytosis of HDL by the liver (e) Increased lipid hydrolysis by lipoprotein lipase
Last Answer : Ans: C
Description : The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level
Last Answer : C. It increases the incidence of myopathy due to statins
Description : Choose the correct statement(s) about actions of insulin: A. It favours translocation of glucose transporters from intracellular site to the plasma membrane B. It enhances transcription of lipoprotein ... vascular endothelium C. It increases production of the enzyme glucokinase D. All of the above
Last Answer : D. All of the above
Description : Familial hypertriaacylglycerolemia is associated with (A) Over production of VLDL (B) Increased LDL concentration (C) Increased HDL concentration (D) Slow clearance of chylomicrons
Description : Which of the following is a recognised feature of abetalipoproteinaemia? 1) a high serum cholesterol 2) palmar xanthomas 3) advanced atherosclerotic vascular disease 4) abnormal red blood cell morphology 5) severe mental retardation
Last Answer : Answers-4 Acanthocytes are seen in abetalipoproteinaemia. Retinitis pigmentosa is seen in abetalipoproteinaemia. Mental retardation is not present but motor abnormalities and neurodegenerative are seen.
Description : Abetalipoproteinaemia occurs due to a block in the synthesis of (A) Apoprotein A (B) Apoprotein B (C) Apoprotein C (D) Cholesterol
Description : A lipoprotein associated with high incidence of coronary atherosclerosis is (A) LDL (B) VLDL (C) IDL (D) HDL
Description : The lipoprotein associated with activation of LCAT is (A) HDL (B) LDL (C) VLDL (D) IDL
Description : Serum potassium level decreases in (A) Familial periodic paralysis (B) Addison’s disease (C) Renal failure (D) All of these
Description : Subacute combined degeneration of cord is caused due to deficiency of (A) Niacin (B) Cobalamin (C) Biotin (D) Thiamin VITAMINS 117
Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.
Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.
Description : The immediate parent of α, β and γ endorphins is (A) Pro-opiomelanocortin (B) β-lipotropin (C) ATCH (D) Lipoprotein
Description : Correct ordering of lipoprotein molecules from lowest to the greater density is (A) LDL, IDL, VLDL, chylomicron (B) Chylomicron, VLDL, IDL, LDL (C) VLDL, IDL, LDL, chylomicron (D) LDL, VLDL, IDL, chylomicron
Description : The major source of extracellular cholesterol for human tissue is (A) Very low density lipoprotein (B) High density lipoprotein (C) Low density lipoprotein (D) Albumin
Description : The compound which has the lowest density is (A) Chylomicron (B) β-Lipoprotein (C) α-Lipoprotein (D) pre β-Lipoprotein
Description : The lipoprotein with the fastest electrophoretic mobility and lowest TG content are (A) VLDL (B) LDL (C) HDL (D) Chylomicrones
Description : This lipoprotein removes cholesterol from the body (A) HDL (B) VLDL (C) IDL (D) Chylomicrons
Description : The first lipoprotein to be secreted by the liver is (A) VLDL (B) nascent VLDL (C) LDL (D) IDL
Description : The β-lipoprotein fraction increases in severe (A) Diabetes Mellitus (B) Uremia (C) Nephritis (D) Muscular dystrophy
Description : The protein moiety of lipoprotein is known as (A) Apoprotein (B) Pre-protein (C) Post-protein (D) Pseudoprotein
Description : Lipoprotein present in cell membrane is by nature: (A) Hydrophilic (B) Hydrophobic (C) Both (A) and (B) (D) None of these
Description : Lecithins combine with protein to form (A) Phosphoprotein (B) Mucoprotein (C) Lipoprotein (D) Glycoprotein
Description : The lipoprotein richest in cholesterol is (A) Chylomicrons (B) VLDL (C) LDL (D) HDL
Description : A lipoprotein inversely related to the incidence of coronary artherosclerosis is (A) VLDL (B) IDL (C) LDL (D) HDL
Description : The apolipoprotein which acts as actiator of extrahepatic lipoprotein is (A) Apo-A (B) Apo-B (C) Apo-C (D) Apo-D
Description : The lipoprotein with the fastest electrophoretic mobility and the lowest triglyceride content is (A) Chylomicron (B) VLDL (C) IDL (D) HDL
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Description : Which of the following is a dipeptide? (A) Anserine (B) Glutathione (C) Glucagon (D) β -Lipoprotein
Description : What is the normal level of lipoprotein (a) ?
Last Answer : In 40% population, there is no detectable level of Lp(a) in serum. In 20% of population, the Lp(a) concentration in blood is more than 30 mg/dl, and these persons are susceptible to heart attack at a younger age.
Description : What is the significance of lipoprotein (a)?
Last Answer : Lp(a) is associated with heart attacks at the age of 30 or 40 years. Indians have a higher level of Lp(a) than Europeans.
Description : What is lipoprotein(a) ?
Last Answer : It is attached to apo B-100 by a disulfide bond. It has significant homology with plasminogen. So it interferes with plasminogen activation and impairs fibrinolysis (Fig.14.10). This leads to unopposed intravascular thrombosis and possible myocardial infarction.
Description : Highest content of triglycerides is seen in which lipoprotein?
Last Answer : Chylomicrons.
Description : Maximum cholesterol content is in which lipoprotein?
Last Answer : LDL (Beta lipoprotein).