The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level

The following is true of bezafibrate except:
A. It activates lipoprotein lipase
B. It mainly lowers serum triglyceride level with
smaller effect on LDL cholesterol level
C. It increases the incidence of myopathy due
to statins
D. It tends to lower plasma fibrinogen level
by

1 Answer

Answer :

C. It increases the incidence of myopathy due
to statins
by

Related questions

Gemfibrozil has the following features except: A. It lowers plasma LDL cholesterol to a greater extent than triglycerides B. It tends to raise plasma HDL-cholesterol level C. It is a first line drug for type III, type IV and type V hyperlipoproteinemia D. It reduces the incidence of myocardial infarctio

Description : Gemfibrozil has the following features except: A. It lowers plasma LDL cholesterol to a greater extent than triglycerides B. It tends to raise plasma HDL-cholesterol level C. It is a first ... type III, type IV and type V hyperlipoproteinemia D. It reduces the incidence of myocardial infarctio

Last Answer : A. It lowers plasma LDL cholesterol to a greater extent than triglycerides

Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III hyperlipoproteinemia C. It is not effective in diabetes associated hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Description : Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III ... hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Choose the correct statement(s) about actions of insulin: A. It favours translocation of glucose transporters from intracellular site to the plasma membrane B. It enhances transcription of lipoprotein lipase in vascular endothelium C. It increases production of the enzyme glucokinase D. All of the above

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Last Answer : D. All of the above

Specific drug therapy to lower serum triglycerides (TG) in a subject with normal LDL-cholesterol level is indicated: A. In all subjects with serum TG> 150 mg/dl B. In subjects with existing coronary artery disease and serum TG > 150 mg/dl C. In subjects with HDL-cholesterol < 40 mg/dl and serum TG > 150 mg/dl D. Both 'B' and 'C' are correct

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Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid

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Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor α: A. Lovastatin B. Atorvastatin C. Bezafibrate D. Nicotinic acid

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Which of the following hypolipidemic drugs is most effective in raising HDL-cholesterol level and lowers serum triglycerides: A. Nicotinic acid B. Fenofibrate C. Cholestyramine D. Pravastatin

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Last Answer : A. Nicotinic acid

A patient with coronary artery disease has raised serum triglyceride level (500 mg/dl) but normal total cholesterol level (150 mg/dl). Which hypolipidemic drug should be prescribed: A. Probucol B. Gemfibrozil C. Cholestyramine D. Lovastatin

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Last Answer : B. Gemfibrozil

Select the hypocholesterolemic drug which interferes with intestinal absorption of bile salts and cholesterol, and secondarily increases cholesterol turnover in the liver: A. Gemfibrozil B. Cholestyramine C. Lovastatin D. Bezafibrate

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Metabolic actions of estrogens tend to cause the following except: A. Anabolism B. Impaired glucose tolerance C. Rise in plasma LDL-cholesterol D. Salt and water retention

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The following is true of simvastatin except: A. It is more potent than lovastatin B. At the highest recommended dose, it causes greater LDL-cholesterol lowering than lovastatin C. It does not undergo first pass metabolism in liver D. It can raise HDL-cholesterol level when the same is low at base line

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With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

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With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

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What is true of nicotinic acid as well as nicotinamide: A. Both possess vitamin B3 activity B. Both cause cutaneous vasodilatation C. Both lower plasma triglyceride and VLDL levels D. Both cause hyperglycaemia after prolonged medication

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n addition to counteracting potassium loss, triamterene also opposes the following consequence of thiazide/furosemide therapy: A. Hyperuricaemia B. Rise in plasma LDL-cholesterol C. Magnesium loss D. Both ‘A’ and ‘C’ are correct

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The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril

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The lipoprotein richest in cholesterol is (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

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Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar leve

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The rare but characteristic adverse effect of HMGCoA reductase inhibitors is: A. Onycolysis B. Myopathy C. Alopecia D. Oculomucocutaneous syndrome

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‘Clearing factor’ is (A) Lipoprotein lipase (B) Crotonase (C) 7-dehydro cholesterol (D) β-sitosterol

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Last Answer : Answer : A

This interferes with cholesterol absorption (A) Lipoprotein lipase (B) Creatinase (C) 7-dehydrocholesterol (D) β-sitosterol

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A non-functional plasma enzyme is (A) Psudocholinesterase (B) Lipoprotein lipase (C) Proenzyme of blood coagulation (D) Lipase

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Last Answer : Answer : A

The triacyl glycerol present in plasma lipoproteins are hydrolyzed by (A) Linqual lipase (B) Pancreatic lipase (C) Colipase (D) Lipoprotein lipase

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Last Answer : Answer : D

The following is true of clopidogrel except: A. It is a GPIIb/IIIa receptor antagonist B. It inhibits fibrinogen induced platelet aggregation C. It is indicated for prevention of stroke in patients with transient ischaemic attacks D. It is a prodrug

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How do statins lower blood cholesterol level? -Biology

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Answer: a, b, c, d Free oxygen radicals are chemical species that are intermediates in the normal process of cellular respiration. Oxidants that are free radicals have been implicated as initiators of reactions which lead to a variety of cellular injuries. Oxidants are derived from several sources, notably phagocytes. Among the effects of oxygen free radicals are membrane lipid peroxidation, DNA strand breaks, cytoskeletal disassembly and inhibition of glucose metabolism leading to decreased cellular ATP concentrations. (Figure 6-16) 187 Which of the following acute-phase protein levels are increased in human plasma following acute inflammation? a. C-reactive protein b. Serum amyloid c. a -Proteinase inhibitor d. Fibrinogen e. Albumin

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Last Answer : Answer: a, b, c, d The acute-phase response is a series of homeostatic responses of the organism to tissue injury in infection and inflammation. After an inflammatory stimulus occurs, a number ... 30% to 50% of the level before injury. The reason for the decrease in production is poorly understood

If you suspect major deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence? (a) Haemocytes (b) Serum globulins (c) Fibrinogen in plasma (d) Serum albumins

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Last Answer : (b) Serum globulins

Which one of the following is correct? (a) Lymph = Plasma + RBC + WBC (b) Blood = Plasma + RBC + WBC + Platelets (c) Plasma = Blood – Lymphocytes (d) Serum = Blood + Fibrinogen

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Last Answer : (b) Blood = Plasma + RBC + WBC + Platelets

What is true of tamoxifen: A. It can induce endometrial proliferation in postmenopausal women B. It exerts antiestrogenic activity in bone C. It raises LDL-cholesterol levels D. It is ineffective in estrogen receptor-negative breast cancer

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Last Answer : A. It can induce endometrial proliferation in postmenopausal women

Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) Activation of triglyceride lipase as a result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin

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Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

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Last Answer : C. Uric acid

The following is true about actions of ethylalcohol: A. It exerts anticonvulsant action followed by lowering of seizure threshold B. It lowers pain threshold C. It increases confidence and reduces number of errors D. It increases heat production and helps to keep warm in cold weather

Description : The following is true about actions of ethylalcohol: A. It exerts anticonvulsant action followed by lowering of seizure threshold B. It lowers pain threshold C. It increases confidence and reduces number of errors D. It increases heat production and helps to keep warm in cold weather

Last Answer : A. It exerts anticonvulsant action followed by lowering of seizure threshold

Bleeding complications are frequently associated with fibrinolytic therapy. Which of the following statement(s) concerning complications of fibrinolytic therapy is/are true? a. Careful monitoring of prothrombin time and aPTT time are necessary to avoid bleeding complications b. A level of serum fibrinogen less than 100 mg/dl is associated with an increased risk of bleeding c. Recent (less than 10 days) major surgery is a contraindication to systemic but not regional fibrinolytic therapy d. A patient with a cerebrovascular event occurring less than two months ago can be treated with fibrinolytic therapy if head CT scan is normal

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Last Answer : Answer: b Fibrinolytic therapy induces a hemostatic defect through a combination of factors. Hypofibrinogenemia and fibrin degradation products inhibit fibrin polymerization and, in combination ... is considered a major relative contraindication to either regional or systemic thrombolytic therapy

Serum lipase level increases in (A) Paget’s disease (B) Gaucher’s disease (C) Acute pancreatitis (D) Diabetes mellitus

Description : Serum lipase level increases in (A) Paget’s disease (B) Gaucher’s disease (C) Acute pancreatitis (D) Diabetes mellitus

Last Answer : Answer : C

Increased serum levels of which of the following may be associated with a decreased risk of atherosclerosis? (a) Very low-density lipoproteins (VLDL) (b) Low-density lipoproteins (LDL) (c) Intermediate – density lipoproteins (IDL) (d) High-density lipoproteins (HDL) (e) Cholesterol

Description : Increased serum levels of which of the following may be associated with a decreased risk of atherosclerosis? (a) Very low-density lipoproteins (VLDL) (b) Low-density lipoproteins (LDL) (c) Intermediate – density lipoproteins (IDL) (d) High-density lipoproteins (HDL) (e) Cholesterol

Last Answer : Ans: D

Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above

Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above

Last Answer : D. All of the above

Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects

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Last Answer : D. It produces prominent extrapyramidal side effect

Which of the following statement(s) is/are true concerning metabolic derangements in sepsis and the systemic inflammatory response syndrome which may follow progressive shock? a. Alterations in glucose metabolism lead to the development of efficient substrate utilization b. A progressive rise in serum triglyceride levels result from less efficient clearance and increased hepatic lipogenesis c. A net negative nitrogen balance occurs due to the oxidative metabolism of proteins to meet energy needs d. The serum aromatic amino acids fall rapidly as they are actively used in oxidative metabolism

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Injection of adrenaline along with a local anaesthetic serves the following purpose: A. Lowers the concentration of the local anaesthetic to produce nerve block B. Prolongs the duration of local anaesthesia C. Increases the anaesthetised area D. Reduces the local toxicity of the local anaesthetic

Description : Injection of adrenaline along with a local anaesthetic serves the following purpose: A. Lowers the concentration of the local anaesthetic to produce nerve block B. Prolongs the duration of local anaesthesia C. Increases the anaesthetised area D. Reduces the local toxicity of the local anaesthetic

Last Answer : B. Prolongs the duration of local anaesthesia

The lipoprotein with the fastest electrophoretic mobility and the lowest triglyceride content is (A) Chylomicron (B) VLDL (C) IDL (D) HDL

Description : The lipoprotein with the fastest electrophoretic mobility and the lowest triglyceride content is (A) Chylomicron (B) VLDL (C) IDL (D) HDL

Last Answer : Answer : D

Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal individual following a 12 hr fast? (A) Chylomicrons (B) VLDL (C) Both VLDL and LDL (D) LDL

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