Answer: ABCDE DISCUSSION: Intramolecular and intermolecular cross-links are crucial for collagen structural stability. Formation of cross-links can be inhibited by two pharmacologic agents: beta-aminopropionitrile inhibits the enzyme lysyl oxidase, and D-penicillamine binds to collagen substrate directly to prevent collagen cross-link formation. Iron is a cofactor for prolyl hydroxylase, which is important for collagen synthesis. In high enough concentration, proline analogs prevent collagen formation with minimal effects on noncollagenase protein synthesis