Description : Which of the following interfere with normal collagen formation or cross-linking? A. Beta-aminopropionitrile. B. Iron chelators. C. Vitamin C depletion. D. Proline analogs (e.g., cis-hydroxyproline). E. D-Penicillamine.
Last Answer : Answer: ABCDE DISCUSSION: Intramolecular and intermolecular cross-links are crucial for collagen structural stability. Formation of cross-links can be inhibited by two ... concentration, proline analogs prevent collagen formation with minimal effects on noncollagenase protein synthesis
Description : Collagen and elastin have the following similarity: (A) Both are triple helices (B) Both have hydroxyproline residues (C) Both have hydrolysine residues (D) Both are glycoproteins
Last Answer : Answer : A
Description : All the following statement about hydroxyproline are true except (A) There is no codon for hydroxyproline (B) It is present in large amounts in collagen (C) Free proline cannot be hydroxylated to hydroxyproline (D) Hydroxylation of proline residues is catalysed by a dioxygenase
Last Answer : Answer : D
Description : A protein rich in hydroxyproline is (A) Prolamin (B) Procollagen (C) Collagen (D) Proinsulin
Last Answer : Answer : C
Description : Which of the following statement(s) is/are true concerning the proliferative phase of wound healing? a. The macrophage is the predominant cell type b. The pink or purple-red appearance of a wound ... amino acids, hydroxyproline and hydroxylysine d. The predominant collagen type in a scar is type 3
Last Answer : Answer: b, c The proliferative phase of wound healing begins with the formation of a provisional matrix of fibrin and fibronectin as part of the initial clot formation. Initially, the provisional ... The principal collagen type scar is type 1, with lesser amounts of type 3 collagen also present
Description : Vitamin for the formation of collagen fibres, teeth, bone, R.B.C. is (a) Vit. K (b) Vit. D (c) Vit. A (d) Vit. C
Last Answer : (d) Vit. C
Description : A deficiency of copper effects the formation of normal collagen by reducing the activity of which of the following enzyme? (A) Prolyl hydroxylase (B) Lysyl oxidase (C) Lysyl hydroxylase (D) Glucosyl transferase
Last Answer : Answer : B
Description : Sulphur is made available to the body by the amino acids: (A) Cystine and methionine (B) Taurine and alanine (C) Proline and hydroxyproline (D) Arginine and lysine MINERAL METABOLISM 191
Description : Covalent modification of an enzyme usually involves phosphorylation / dephosphorylation of (A) Serine residue (B) Proline residue (C) Hydroxylysine residue (D) Hydroxyproline residue
Description : Carnitine is synthesized from (A) Lysine and methionine (B) Glycine and arginine (C) Aspartate and glutamate (D) Proline and hydroxyproline
Description : All of the following statements about proline are true except (A) It is an imino acid (B) It can be synthesized from glutamate (C) It can be catabolised to glutamate (D) Free proline can be hydroxylated to hydroxyproline
Description : The amino acid from which synthesis of the protein of hair keratin takes place is (A) Alanine (B) Methionine (C) Proline (D) Hydroxyproline
Description : Ascorbic acid is required to synthesise all of the following except (A) Collagen (B) Bile acids (C) Bile pigments (D) Epinephrine
Description : Vitamin A is required for the formation of a light receptor protein known as (A) Globulin (B) Lypoprotein (C) Chomoprotein (D) Rhodospin
Description : In contrast to adult wound healing with scar formation, which of the following are characteristic of scarless fetal skin repair? A. Matrix rich in hyaluronic acid. B. Increased inflammatory response. C. Increased production of TGF-b. D. No collagen deposition. E. Minimal angiogenesis.
Last Answer : Answer: AE DISCUSSION: The ability of a fetus to heal without scar formation depends on its gestational age at the time of injury and the size of the wound defect. In ... repair has possible clinical applications in the modulation of adult fibrotic diseases and abnormal scar-forming conditions
Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.
Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot
Description : Vitamin E protects the polyunsaturated fatty acids from oxidation by molecular oxygen in the formation of (A) Superoxide (B) Peroxide (C) Trioxide (D) All of these
Description : Vitamin K is required for (a) change of prothrombin into thrombin (b) synthesis of prothrombin (c) change of fibrinogen to fibrin (d) formation of thromboplastin.
Last Answer : (b) synthesis of prothrombin
Description : Which vitamin is required for formation of Prothrombin?
Last Answer : Vitamin K
Description : Fibronectin has binding sites for all of the following except (A) Glycophorin (B) Collagen (C) Heparin (D) Integrin receptor
Description : Marfan’s syndrome results from a mutation in the gene coding: (A) Collagen (B) Elastin (C) Fibrillin (D) Keratin
Description : A protein having both structural and enzymatic traits is (A) Myosin (B) Collagen (C) Trypsin (D) Actin
Description : The number of helices present in a collagen molecule is (A) 1 (B) 2 (C) 3 (D) 4
Description : Proteins that constitute keratin, collagen and elastin in body are (A) Protamines (B) Phosphol proteins (C) Scleroproteins (D) Metaproteins
Description : Which of the following protein is rich in cysteine? (A) Elastine (B) Collagen (C) Fibrin (D) Keratin
Description : Collagen is very rich in (A) Glycine (B) Serine (C) Aspartic acid (D) Glutamic acid
Description : Abnormal collagen structure is seen in all of the following except (A) I-cell disease (B) Osteogenesis imperfecta (C) Menke’s disease (D) Ehlers-Danlos sydrome
Description : The most abundant collagen in cartilages is (A) Type I (B) Type II (C) Type III (D) Type IV
Description : The most abundant protein in bones is (A) Collagen type I (B) Collagen type II (C) Collagen type III (D) Non-collagen proteins
Description : All of the following are glycoproteins except (A) Collagen (B) Albumin (C) Transferrin (D) IgM
Description : The most abundant protein in mammals is (A) Albumin (B) Haemoglobin (C) Collagen (D) Elastin
Description : A protein rich in cysteine is (A) Collagen (B) Keratin (C) Haemoglobin (D) Gelatin
Description : The action of Vitamin K in formation of clotting factor is through (A) Post transcription (B) Post translation (C) Golgi complex (D) Endoplasmic reticulum
Description : One of the main functions of Vitamin K is the cofactor for (A) Carboxylase for the formation of γ--carboxy glutamate (B) Methylation by S-adenosyl methionine (C) Carboxylation by biotin (D) One carbon transfer by tetra hydrofolate
Description : One of the main functions of Vitamin K is cofactor for (A) Carboxylate for the formation of γ carboxyglutamate (B) Methylation of δ-adenosyl methionine (C) Carboxylation of biotin (D) One carbon transfer by tetrahydrofolate
Description : Vitamin K is a cofactor for (A) Gamma carboxylation of glutamic acid residue (B) β-Oxidation of fatty acid (C) Formation of γ-amino butyrate (D) Synthesis of tryptophan
Description : The number of molecules of porphobilinogen required for the formation of a tetrapyrrole i.e., a porphyrin is (A) 1 (B) 2 (C) 3 (D) 4
Description : Vitamin required for metabolism of diols e.g. conversion of ethylene glycol to acetaldehyde is (A) Thiamin (B) Cobalamin (C) Pyridoxine (D) Folic acid
Description : ATP is required for (A) Fusion of 40S and 60S of ribosome (B) Accommodation tRNA amino acid in a site of ribosome (C) Movement of ribosome along mRNA (D) formation of tRNA amino acid complex
Description : GTP is not required for (A) Capping L of mRNA (B) Fusion of 40S and 60S of ribosome (C) Accommodation of tRNA amino acid (D) Formation of tRNA amino acid complex
Description : After formation of replication fork (A) Both the new strands are synthesized discontinuously (B) One strand is synthesized continuously and the other discontinuously (C) Both the new strands are synthesized continuously (D) RNA primer is required only for the synthesis of one new strand
Description : Iodine is required in human body for (A) Formation of thyroxine (B) Formation of Glutathione (C) Formation of potassium iodide (D) Adrenalin
Description : Choline is not required for the formation of (A) Lecithins (B) Acetyl choline (C) Sphingomyelin (D) Cholic acid
Description : Methylcobalamin is required for formation of (A) Serin from glycine (B) Glycine from serine (C) Methionine from homocysteine (D) All of these
Description : The following is required for the formation of coenyzme A: (A) ATP (B) GTP (C) CTP (D) None of these
Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these
Description : The amino acids required for creatine formation: (A) Glycine (B) Arginine (C) Methionine (D) All of these
Description : Glycine is not required for the formation of (A) Taurocholic acid (B) Creatine (C) Purines (D) Pyrimidines
Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.
Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.