All the following statement about hydroxyproline are true except (A) There is no codon for hydroxyproline (B) It is present in large amounts in collagen (C) Free proline cannot be hydroxylated to hydroxyproline (D) Hydroxylation of proline residues is catalysed by a dioxygenase

All the following statement about hydroxyproline are true except (A) There is no codon for hydroxyproline (B) It is present in large amounts in collagen (C) Free proline cannot be hydroxylated to hydroxyproline (D) Hydroxylation of proline residues is catalysed by a dioxygenase
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Answer : D
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All of the following statements about proline are true except (A) It is an imino acid (B) It can be synthesized from glutamate (C) It can be catabolised to glutamate (D) Free proline can be hydroxylated to hydroxyproline

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Last Answer : Answer : D

All of the following are required for hydroxylation of proline residues except (A) Ascorbic acid (B) Glutamate (C) Ferrous ions (D) Molecular oxygen

Description : All of the following are required for hydroxylation of proline residues except (A) Ascorbic acid (B) Glutamate (C) Ferrous ions (D) Molecular oxygen

Last Answer : Answer : B

Collagen and elastin have the following similarity: (A) Both are triple helices (B) Both have hydroxyproline residues (C) Both have hydrolysine residues (D) Both are glycoproteins

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Last Answer : Answer : A

Which of the following interfere with normal collagen formation or cross-linking? A. Beta-aminopropionitrile. B. Iron chelators. C. Vitamin C depletion. D. Proline analogs (e.g., cis-hydroxyproline). E. D-Penicillamine.

Description : Which of the following interfere with normal collagen formation or cross-linking? A. Beta-aminopropionitrile. B. Iron chelators. C. Vitamin C depletion. D. Proline analogs (e.g., cis-hydroxyproline). E. D-Penicillamine.

Last Answer : Answer: ABCDE DISCUSSION: Intramolecular and intermolecular cross-links are crucial for collagen structural stability. Formation of cross-links can be inhibited by two ... concentration, proline analogs prevent collagen formation with minimal effects on noncollagenase protein synthesis

Sulphur is made available to the body by the amino acids: (A) Cystine and methionine (B) Taurine and alanine (C) Proline and hydroxyproline (D) Arginine and lysine MINERAL METABOLISM 191

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Last Answer : Answer : A

Covalent modification of an enzyme usually involves phosphorylation / dephosphorylation of (A) Serine residue (B) Proline residue (C) Hydroxylysine residue (D) Hydroxyproline residue

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Last Answer : Answer : A

Carnitine is synthesized from (A) Lysine and methionine (B) Glycine and arginine (C) Aspartate and glutamate (D) Proline and hydroxyproline

Description : Carnitine is synthesized from (A) Lysine and methionine (B) Glycine and arginine (C) Aspartate and glutamate (D) Proline and hydroxyproline

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The amino acid from which synthesis of the protein of hair keratin takes place is (A) Alanine (B) Methionine (C) Proline (D) Hydroxyproline

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Last Answer : Answer : B

Which of the following statement(s) is/are true concerning the proliferative phase of wound healing? a. The macrophage is the predominant cell type b. The pink or purple-red appearance of a wound is due to ingrowth and proliferation of endothelial cells c. Collagen, the dominant structural molecule of the wound matrix, contains two unique amino acids, hydroxyproline and hydroxylysine d. The predominant collagen type in a scar is type 3

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The vitamin required for the formation of hydroxyproline (in collagen) is (A) Vitamin C (B) Vitamin A (C) Vitamin D (D) Vitamin E

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A protein rich in hydroxyproline is (A) Prolamin (B) Procollagen (C) Collagen (D) Proinsulin

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Hydroxylation of Proline and Lysine in a protein is effected by (A) Vitamin B1 (B) Vitamin B2 (C) Vitamin B6 (D) Vitamin C

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Which of the following is/are true concerning wound fibroblasts? A. Fibroblasts synthesize and secrete collagen molecules. B. Wound fibroblasts are derived from blood-borne precursor cells. C. Fibroblasts migrate to a wound along fibrin strands, which are used as a scaffold. D. Large amounts of fibrin or blood clot can act as a physical barrier to fibroblast penetration, which delays normal wound healing.

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Last Answer : Answer: ACD DISCUSSION: Fibroblasts appear in the wound on about the third day of healing and begin to synthesize and secrete collagen molecules. Wound fibroblasts arrive from cells surrounding ... enzymes, and large amounts of fibrin and blood clot prevent fibroblasts from entering the wound

Hydroxylation of phenylalanine requires all of the following except (A) Phenylalanine hydroxylase (B) Tetrahydrobiopterin (C) NADH (D) Molecular oxygen

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Last Answer : Answer : C

All the following amino acids are nonessential except (A) Alanine (B) Histidine (C) Cysteine (D) Proline

Description : All the following amino acids are nonessential except (A) Alanine (B) Histidine (C) Cysteine (D) Proline

Last Answer : Answer : B

Optical isomers of all aminoacids exist except (A) Glycine (B) Arginine (C) Alanine (D) Hydroxy proline

Description : Optical isomers of all aminoacids exist except (A) Glycine (B) Arginine (C) Alanine (D) Hydroxy proline

Last Answer : Answer : A

All the following statements about haptens are true except (A) They have high molecular weights (B) They cannot elicit an immune response by themselves (C) When combined with some other large molecule, they can elicit an immune response (D) Once an immune response develops, the free hapten can be recognized by the antibody

Description : All the following statements about haptens are true except (A) They have high molecular weights (B) They cannot elicit an immune response by themselves (C) When combined with some other large ... response (D) Once an immune response develops, the free hapten can be recognized by the antibody

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Tryptophan pyrolase is currently known as (A) Tryptophan deaminase (B) Tryptophan dioxygenase (C) Tryptophan mono oxygenase (D) Tryptophan decarboxylase

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Homogentisic oxidase is an (A) Oxidase (B) Monooxygenase (C) Dioxygenase (D) Anaerotic dehydrogenase

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Conversion of β-carotene into retinal requires the presence of (A) β-Carotene dioxygenase (B) Bile salts (C) Molecular oxygen (D) All of these

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β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase (C) Hydroxylase (D) Transferase

Description : β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase (C) Hydroxylase (D) Transferase

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All the following statements about charging of tRNA are correct except (A) It is catalysed by amino acyl tRNA synthetase (B) ATP is converted into ADP and Pi in this reaction (C) The enzyme recognizes the tRNA and the amino acid (D) There is a separate enzyme for each tRNA

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Polysaccharides (A) Contain many monosaccharide units which may or may not be of the same kind (B) Function mainly a storage or structural compounds (C) Are present in large amounts in connective tissue (D) All of these

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Last Answer : D

An –OH group is present in the side chain of (A) Serine (B) Arginine (C) Lysine (D) Proline

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Last Answer : Answer : A

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Abnormal collagen structure is seen in all of the following except (A) I-cell disease (B) Osteogenesis imperfecta (C) Menke’s disease (D) Ehlers-Danlos sydrome

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Last Answer : Answer : B

All of the following are glycoproteins except (A) Collagen (B) Albumin (C) Transferrin (D) IgM

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Last Answer : Answer : B

For glyburide, all of the following metabolic reactions are logical EXCEPT (A) O-demethylation (B) aromatic oxidation (C) benzylic hydroxylation (D) amide hydrolysis

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All of the following statements about tRNA are true except (A) It is synthesized as a large precursor (B) It is processed in the nucelolus (C) It has no codons or anticodons (D) Genes for rRNA are present in single copies

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Last Answer : Answer : D

In adrenal gland the cholesterol is stored (A) Mostly in the free form (B) Mostly in esterified form (C) Large amount of free form and less amount of esterified form (D) Equal amounts of free and esterified form

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Last Answer : Answer : B

All the following statements about recognition of a codon on mRNA by an anticodon on tRNA are correct except (A) The recognition of the third base of the codon is not very precise (B) Imprecise recognition of the third base results in wobble (C) Wobble is partly responsible for the degeneracy of the genetic code (D) Wobble results in incorporation of incorrect amino acids in the protein

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Last Answer : Answer : D

All the following statements about tRNA are correct except (A) A given tRNA can be charged with only one particular amino acid (B) The amino acid is recognized by the anticodon of tRNA (C) The amino acid is attached to end of tRNA (D) The anticodon of tRNA finds the complementary codon on mRNA

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Thyroperoxidase iodinates (A) Free tyrosine in thyroid gland (B) Tyrosine residues of thyroglobulin (C) Tyrosine residues of thyroxine binding globulin (D) Tyrosine residues of thyroxine binding prealbumin

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Last Answer : Answer : B

The α-carbon of all the amino acids is a chirality center except for __________. (a) Glycine (b) Threonine (c) Proline (d) Aspartic acid

Description : The α-carbon of all the amino acids is a chirality center except for __________. (a) Glycine (b) Threonine (c) Proline (d) Aspartic acid

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The number of helices present in a collagen molecule is (A) 1 (B) 2 (C) 3 (D) 4

Description : The number of helices present in a collagen molecule is (A) 1 (B) 2 (C) 3 (D) 4

Last Answer : Answer : C

The number of helices present in a collagen molecule is (A) 1 (B) 2 (C) 3 (D) 4

Description : The number of helices present in a collagen molecule is (A) 1 (B) 2 (C) 3 (D) 4

Last Answer : Answer : C

β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase \ (C) Hydroxylase (D) Transferase

Description : β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase \ (C) Hydroxylase (D) Transferase

Last Answer : (A) β-Carotene dioxygenase

Genetic code is said to be degenerate because (A) It can undergo mutations (B) A large proportion of DNA is non-coding (C) One codon can code for more than one amino acids (D) More than one codons can code for the same amino acids

Description : Genetic code is said to be degenerate because (A) It can undergo mutations (B) A large proportion of DNA is non-coding (C) One codon can code for more than one amino acids (D) More than one codons can code for the same amino acids

Last Answer : Answer : D

Conversion of a procarcinogen into a carcinogen often requires (A) Proteolysis (B) Microsomal hydroxylation (C) Exposure to ultraviolet radiation (D) Exposure to X-rays

Description : Conversion of a procarcinogen into a carcinogen often requires (A) Proteolysis (B) Microsomal hydroxylation (C) Exposure to ultraviolet radiation (D) Exposure to X-rays

Last Answer : Answer : B

Epinephrine is derived from norepinephrine by (A) Decarboxylation (B) Hydroxylation (C) Oxidation (D) N-methylation

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Last Answer : Answer : D

The sequential steps in the conversion of tyrosine to epinephrine are (A) Ring hydroxylation-decarboxylation-side chain hydroxylation-N-methylation (B) Side chain hydroxylation-decarboxylation-ring hydroxylation N-methylation (C) Decarboxylation-ring hydroxylation-side chain hydroxylation-N-methylation (D) N-methylation-decarboxylation-ring and side chain hydroxylation

Description : The sequential steps in the conversion of tyrosine to epinephrine are (A) Ring hydroxylation-decarboxylation-side chain hydroxylation-N-methylation (B) Side chain hydroxylation-decarboxylation- ... chain hydroxylation-N-methylation (D) N-methylation-decarboxylation-ring and side chain hydroxylation

Last Answer : Answer : A

Biotin is essential for (A) Translation (B) Carboxylation (C) Hydroxylation (D) Transamination

Description : Biotin is essential for (A) Translation (B) Carboxylation (C) Hydroxylation (D) Transamination

Last Answer : Answer : B

In renal rickets, the following hydroxylation of Vitamin D3 does not take place: (A) 25 (B) 1 (C) 24 (D) 7

Description : In renal rickets, the following hydroxylation of Vitamin D3 does not take place: (A) 25 (B) 1 (C) 24 (D) 7

Last Answer : Answer : B

Hydroxylation of 25-hydroxy cholecalciferol is promoted by (A) Cytochrome A (B) Panthyroid hormone (C) Cytochrome b (D) cAMP

Description : Hydroxylation of 25-hydroxy cholecalciferol is promoted by (A) Cytochrome A (B) Panthyroid hormone (C) Cytochrome b (D) cAMP

Last Answer : Answer : B

25-hydroxylation of Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestines (D) Pancreas

Description : 25-hydroxylation of Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestines (D) Pancreas

Last Answer : Answer : A

1-hydroxylation of 25-hydroxy Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Description : 1-hydroxylation of 25-hydroxy Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Last Answer : Answer : B

Biotin is involved in which of the following types of reactions? (A) Hydroxylation (B) Carboxylation (C) Decarboxylation (D) Deamination

Description : Biotin is involved in which of the following types of reactions? (A) Hydroxylation (B) Carboxylation (C) Decarboxylation (D) Deamination

Last Answer : Answer : B

In retinal rickets, the following hydroxylation of Vitamin D3 does not take place: (A) 25 (B) 1 (C) 24 (D) 7

Description : In retinal rickets, the following hydroxylation of Vitamin D3 does not take place: (A) 25 (B) 1 (C) 24 (D) 7

Last Answer : Answer : B

Hydroxylation of 25-hydroxy cholecalciferol is promoted by (A) Cytochrome - a (B) Parathyroid hormone (C) Cytochrome-b (D) CAMP

Description : Hydroxylation of 25-hydroxy cholecalciferol is promoted by (A) Cytochrome - a (B) Parathyroid hormone (C) Cytochrome-b (D) CAMP

Last Answer : Answer : B