Description : All of the following occur in orotic aciduria except (A) Increased synthesis of pyrimidine nucleotides (B) Increased excretion of orotic acid in urine (C) Decreased synthesis of cytidine triphosphate (D) Retardation of growth
Last Answer : Answer : A
Description : Orotic aciduria type II reflects the deficiency of the enzyme: (A) Orotate phosphoribosyl transferase (B) Orotidylate decarboxylase (C) Dihydroorotase (D) Dihydroorotate dehydrogenase
Last Answer : Answer : B
Description : Orotic aciduria type I reflects the deficiency of enzymes: (A) Orotate phosphoribosyl transferase and orotidylate decarboxylase (B) Dihydroorotate dehydrogenase (C) Dihydroorotase (D) Carbamoyl phosphate synthetase
Description : Increased protein intake is accompanied by an increased dietary requirement for (A) Thiamine (B) Riboflavine (C) Folic acid (D) Nicotininic acid
Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation
Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.
Description : Safe and adequate daily dietary intake of chromium in adults in mg is (A) 0.01–0.02 (B) 0.02–0.03 (C) 0.03–0.04 (D) 0.05–0.2
Last Answer : Answer : D
Description : Insoinic acid is the biological precursor of (A) Cytosine and Uric acid (B) Adenylve acid and Glucine floc acid (C) Orotic acid and Uridylic acid (D) Adenosine acid Thymidine
Description : Increased urinary excretion of orotic acid can occur in deficiency of (A) Orotate phosphoribosyl transferase (B) OMP decarboxylase (C) Mitochondrial ornithine transcarbamoylase (D) Any of the above
Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate
Description : A cofactor in the conversion of dihydroorotate to orotic acid, catalysed by the enzyme dihydroorotate dehydrogenase is (A) FAD (B) FMN (C) NAD (D) NADP
Last Answer : Answer : C
Description : Uridine diphosphate glucose (UDPG) is (A) Required for metabolism of galactose (B) Required for synthesis of glucuronic acid (C) A substrate for glycogen synthetase (D) All of the above
Last Answer : D
Description : Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Description : Methyl malonic aciduria is seen in the deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Description : The nurse teaches the patient with a high risk for osteoporosis about risk-lowering strategies including which of the following statements? a) Walk or perform weight-bearing exercises out ... alcohol and caffeine consumption in moderation, and performing a regular weight-bearing exercise regimen.
Last Answer : a) Walk or perform weight-bearing exercises out of doors. Risk-lowering strategies for osteoporosis include walking or exercising out of doors, performing a regular weight-bearing exercise ... and vitamin D intake, smoking cessation, and consuming alcohol and caffeine consumption in moderation.
Description : In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine
Description : The probable metabolic defect in gents is (A) A defect in excretion of uric acid by kidney (B) An overproduction of pyrimidines (C) An overproduction of uric acid (D) Rise in calcium leading to deposition of calcium urate
Description : Uric acid is the catabolic end product of (A) Porphyrine (B) Purines (C) Pyrimidines (D) Pyridoxine
Description : Which of the following statements about nucleic acid is most correct? (A) Both pentose nucleic acid and deoxypentose nucleic acid contain the same pyrimidines (B) Both pentose nucleic acid and deoxypentose ... (C) RNA contains cytosine and thymine (D) DNA and RNA are hydrolysed by weak alkali
Description : The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine
Description : Glycine is not required for the formation of (A) Taurocholic acid (B) Creatine (C) Purines (D) Pyrimidines
Description : Conversion of uridine diphosphate into deoxyuridine diphosphate requires all the following except (A) Ribonucleotide reductase (B) Thioredoxin (C) Tetrahydrobiopterin (D) NADPH
Description : The T ψ C arm in the tRNA molecule possesses the sequence (A) T, pseudouridine and C (B) T, uridine and C (C) T, dihydrouridine and C (D) T, adenine and C
Description : In tRNA molecule D arm is named for the presence of the base: (A) Uridine (B) Pseudouridine (C) Dihydrouridine (D) Thymidine
Description : Uracil and ribose form (A) Uridine (B) Cytidine (C) Guanosine (D) Adenosine
Description : Galactose 1-phosphate is converted to uridine diphosphate galactose, the reaction is catalysed by the enzyme: (A) Glactokinase (B) Galactose 1-phosphate uridyl transferase (C) Uridine diphospho galactose 4-epimerase (D) UDP glucose pyrophosphorylase
Description : Coccidiosis can be prevented by dietary administration of C A. Zinc bacitracin B. chlortetracycline C. Salinomycin D. None of the these
Last Answer : chlortetracycline
Description : Which of the following clinical characteristics is associated with Type 2 diabetes (previously referred to as non-insulin-dependent diabetes mellitus [NIDDM])? a) Can control blood glucose ... islet cell antibodies Individuals with Type 2 diabetes do not demonstrate islet cell antibodies.
Last Answer : a) Can control blood glucose through diet and exercise Oral hypoglycemic agents may improve blood glucose levels if dietary modification and exercise are unsuccessful.
Description : Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase
Description : Elevated blood argininosuccinate level is found in (A) Hyperargininemia (B) Argininosuccinic aciduria (C) Citrullinemia (D) Tyrosinosis
Description : Tricorrhexis nodosa is a characteristic finding of (A) Argininosuccinic aciduria (B) Citrullinemia (C) Phenylketonuria (D) Hyperargininemia
Description : Absence of the enzyme argininosuccinate synthetase causes (A) Argininosuccinic aciduria (B) Hyperargininemia (C) Tricorrhexis nodosa (D) Citrullinemia
Description : In spark ignition engines, the knocking tendency can be decreased by a) decreasing compression ratio b) controlling intake throttle c) controlling ignition timing d) adding dopes like tetraethyl lead and ethylene dibromide
Last Answer : Answer: d Explanation: None.
Description : Keeping other parameters constant brake power of diesel engine can be increased by (a) Decreasing the density of intake air (b) Increasing the temperature of intake air (c) Increasing the pressure of intake air (d) Decreasing the pressure of intake air
Last Answer : Ans : c
Description : Simple goiter can be prevented by A) surgery to remove the thyroid gland. B) removal of the pituitary. C) administration of ACTH. D) administration of insulin. E) increasing intake of iodine in the diet.
Last Answer : E) increasing intake of iodine in the diet.
Description : A 47-year-old patient undergoing a complicated laparotomy for bowel obstruction develops a postoperative enterocutaneous fistula. Which of the following statement(s) is/are true concerning parenteral ... use of TPN better prepares the patient for surgery if surgical intervention proves necessary
Last Answer : Answer: a, b, d Patients with gastrointestinal-cutaneous fistulas represent the classical indication for TPN. In such patients, oral intake of food almost invariably results in increased ... treated more aggressively surgically after a defined period of nutritional support (unless closure occurs)
Description : The most common cause of caries in children is, A. Soft diet B. High intake of carbohydrate C. Poor oral hygiene
Last Answer : B. High intake of carbohydrate
Description : Two nitrogen of the pyrimidines ring are obtained from (A) Glutamine and Carbamoyl-p (B) Asparate and Carbamoyl-p (C) Glutamate and NH3 (D) Glutamine and NH3
Description : A key substance in the committed step of pyrimidines biosynthesis is (A) Ribose-5-phosphate (B) Carbamoyl phosphate (C) ATP (D) Glutamine
Description : Nucleic acids can be detected by means of their absorption maxima near 260 nm. Their absorption in this range is due to (A) Proteins (B) Purines and pyrimidines (C) Ribose (D) Deoxyribose
Description : Methylated purines and pyrimidines are characteristically present in (A) mRNA (B) hnRNA (C) tRNA (D) rRNA
Description : Identify the correct molecule which controls the biosynthesis of proteins in living organisms. (A) DNA (B) RNA (C) Purines (D) Pyrimidines
Description : Free ammonia is released during (A) Oxidative deamination of glutamate (B) Catabolism of purines (C) Catabolism of pyrimidines (D) All of these
Description : Increased carbohydrate consumption increases the dietary requirement for (A) Thiamine (B) Riboflavine (C) Pyridoxine (D) Folic acid
Description : In humans, a dietary essential fatty acid is (A) Palmitic acid (B) Stearic acid (C) Oleic acid (D) Linoleic acid
Description : The following ketoacid is involved in fixing dietary NH3 into amino acid: (A) Pyruvate (B) Oxalo acetate (C) Oxalo succinate (D) α-keto glutarate
Description : The standard management oral anticoagulant therapy for chronic treatment of venous thromboembolism is with the drug warfarin. Which of the following statement(s) is/are true concerning the administration ... warfarin be continued for at least one year after initial episode of deep venous thrombosis
Last Answer : Answer: a, b Warfarin interferes with the vitamin K dependent clotting factors II, VII, IX and X, protein C, and protein S. An important complication of warfarin is skin ... the benefit from anticoagulant therapy and thus is the basis for discontinuing warfarin administration at this time
Description : Ketorolac: A. Is a nonsteroidal anti-inflammatory drug (NSAID) approved for intravenous, intramuscular, and oral administration. B. Can be used indefinitely for postoperative analgesia. C. Can cause renal dysfunction. D. May decrease surgical blood loss.
Last Answer : Answer: AC DISCUSSION: Ketorolac tromethamine, an NSAID, is approved by the FDA for intravenous, intramuscular, and oral administration. The agent is an effective analgesic with minimal side ... Additionally, it is recommended that ketorolac should not be used for more than 5 consecutive days
Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion
Last Answer : Ans: D
Description : Factor at increase risk of aspiration includes A. drinking clear fluids 8 hours before operation B. gastro esophageal reflux C. chewing gum D. Two hours preoperative oral clear fluid administration
Last Answer : Ans: B