Trimethoprim inhibits bacteria without affecting mammalian cells because:
A. It does not penetrate mammalian cells
B. It has high affinity for bacterial but low
affinity for mammalian dihydrofolate reductase enzyme
C. It inhibits bacterial folate synthetase as well
as dihydrofolate reductase enzymes
D. All of the above
A. It does not penetrate mammalian cells
B. It has high affinity for bacterial but low
affinity for mammalian dihydrofolate reductase enzyme
C. It inhibits bacterial folate synthetase as well
as dihydrofolate reductase enzymes
D. All of the above