Rodent infestations can be extremely difficult to eliminate, but there are a few effective ways to eliminate rodents without calling an exterminator. It is essential to avoid feeding the rodents or leaving food out where rodents can access it. Always seal garbage cans tightly and do not put household garbage in compost piles. Wherever possible, cut off the rodent's water supply. Water can accumulate in flower pots, equipment and toys. If the rodents do not have accessible water, they will likely move to a different location.