DefinitionFamilial dysbetalipoproteinemia is a disorder passed down through families in which there are high amounts of cholesterol and triglycerides in the blood.Alternative NamesType III hyperlipoproteinemia; Deficient or defective apolipoprotein ECauses, incidence, and risk factorsA genetic defect causes this condition. The defect results in the buildup of large lipoprotein particles that contain both cholesterol and triglycerides, a type of fat. The disease is linked to defects in the gene for apolipoprotein E in many cases.Hypothyroidism, obesity, or diabetes can make the condition worse. Risk factors for familial dysbetalipoproteinemia include a family history of the disorder or coronary artery disease.SymptomsSymptoms may not be seen until age 20 or older.Yellow deposits of fatty ma