DefinitionMultiple system atrophy (MSA) is a rare condition that causes symptoms similar to Parkinson's disease. However, patients with MSA have more widespread damage to the autonomic nervous system. This is the part of the nervous system that controls important organ functions such as heart rate, blood pressure, digestive system muscles, and sweating.Alternative NamesShy-Drager syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndromeCauses, incidence, and risk factorsThe cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60.SymptomsMSA damages the nervous system, which can cause the following symptoms:Changes in facial expression "Mask" appearance to faceMay be unable to close mouthReduced ability to show facia