Description : Cholinergic muscarinic receptor stimulation produces the following effects except: A. Sweating B. Rise in blood pressure C. Bradycardia D. Urination
Last Answer : B. Rise in blood pressure
Description : Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor
Last Answer : A. Muscarinic cholinergic receptor
Description : Muscarinic cholinergic receptors: A. Are located only on parasympathetically innervated effector cells B. Mediate responses by opening an intrinsic Na+ ion channel C. Are present on vascular endothelium which has no cholinergic nerve supply D. Predominate in the autonomic ganglia
Last Answer : C. Are present on vascular endothelium which has no cholinergic nerve supply
Description : Pyridostigmine differs from neostigmine in that: A. It is more potent orally B. It is longer acting C. It produces less muscarinic side effects D. It does not have any direct action on NM receptors
Last Answer : B. It is longer acting
Description : Initial bradycardia caused by intramuscular injection of atropine is believed to be caused by: A. Stimulation of medullary vagal centre B. Stimulation of vagal ganglia C. Blockade of M2 receptors on SA nodal cells D. Blockade of muscarinic autoreceptors on vagal nerve endings
Last Answer : D. Blockade of muscarinic autoreceptors on vagal nerve endings
Description : The major postjunctional cholinergic receptor is of the muscarinic type at the following site: A. Postganglionic parasympathetic B. Adrenal medulla C. Autonomic ganglia D. Neuromuscular junction
Last Answer : A. Postganglionic parasympathetic
Description : Actions of pilocarpine include the following except: A. Sweating B. Salivation C. Miosis D. Cycloplegia
Last Answer : D. Cycloplegia
Description : All of the following subserve as intracellular second messengers in receptor mediated signal transduction except: A. Cyclic AMP B. Inositol trisphosphate C. Diacyl glycerols D. G proteins
Last Answer : D. G proteins
Description : The cardiac muscarinic receptors: A. Are of the M1 subtype B. Are of the M2 subtype C. Are selectively blocked by pirenzepine D. Function through the PIP2 → IP3/DAG pathway
Last Answer : B. Are of the M2 subtype
Description : Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: A. Shorter duration of action B. Longer duration of action C. Direct action on muscle end-plate D. Selective inhibition of true cholinesterase
Last Answer : A. Shorter duration of action
Description : The smooth muscle structure that is relaxed by cholinergic drugs is: A. Colon B. Gastric fundus C. Major bronchi D. Bladder trigone
Last Answer : D. Bladder trigone
Description : Mu opioids have which of the following effects on respiratory rate: a) Stimulation, then depression Mu opioids also cause bradycardia, hypothermia, and constipation. b) No change Kappa opioids result ... nor kappa, nor delta opoids depress respiratory rate as its only effect upon respiratory rate.
Last Answer : a) Stimulation, then depression Mu opioids also cause bradycardia, hypothermia, and constipation.
Description : Betaxolol differs from timolol in that it: A. Is a β1 selective blocker B. Is more efficacious in glaucoma C. Produces less ocular side effects D. Is longer acting
Last Answer : A. Is a β1 selective blocker
Description : Timolol eye drops are preferred over pilocarpine eye drops by glaucoma patients because: A. Timolol is more effective than pilocarpine B. Timolol acts by enhancing uveo-scleral outflow C. Timolol produces less ocular side effects D. There are no contraindications to timolol
Last Answer : C. Timolol produces less ocular side effects
Description : Acetylcholine has no therapeutic application because: A. None of its actions are beneficial in any condition B. Its effects are transient C. It produces wide spread actions affecting many organs D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin
Last Answer : A. Constipation caused by codeine
Description : Muscarinic cholinergic receptors (a) Are located only on parasympathetically innervated effector cells (b) Mediate responses by opening an instrinsic Na+ ion channel (c) Are present on vascular endothelium which has no cholinergic nerve supply (d) Predominate in the autonomic ganglia
Last Answer : Ans: C
Description : The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor
Last Answer : C. Suppression of maximal agonist response
Description : A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor
Last Answer : A. Insulin receptor
Description : Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign
Last Answer : C. Affinity and intrinsic activity with a + sign
Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable
Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable
Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor
Last Answer : C. Agonists induce a conformational change in the receptoR
Description : Agonistic action on which of the following adrenergic receptors located on ciliary epithelial cells reduces aqueous secretion: A. β1 receptor B. β2 receptor C. α1 receptor D. α2 receptor
Last Answer : D. α2 receptor
Description : 81. Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus) (1) Cortisol, testosterone (2) Insulin, glucagon (3) Thyroxin, Insulin (4) Somatostatin, oxytocin
Last Answer : Cortisol, testosterone
Description : The receptor transduction mechanism with the fastest time-course of response effectuation is: A. Adenylyl cyclase-cyclic AMP pathway B. Phospholipase C-IP3: DAG pathway C. Intrinsic ion channel operation D. Protein synthesis modulation
Last Answer : C. Intrinsic ion channel operation
Description : Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor
Last Answer : B. Steroid receptor
Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor
Last Answer : D. GABA-benzodiazepine receptor
Description : The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor
Last Answer : D. G protein coupled receptor
Description : Agonists affect the receptor molecule in the following manner: A. Alter its amino acid sequence B. Denature the receptor protein C. Alter its folding or alignment of subunits D. Induce covalent bond formation
Last Answer : C. Alter its folding or alignment of subunits
Last Answer : C. Agonists induce a conformational change in the receptor
Description : Which of the following findings in the patient who has sustained a head injury indicate increasing intracranial pressure (ICP)? a) Widened pulse pressure Additional signs of increasing ICP ... regarded as unfavorable because hyperthermia may indicate brain stem damage, a poor prognostic sign.
Last Answer : a) Widened pulse pressure Additional signs of increasing ICP include increasing systolic blood pressure, bradycardia, rapid respirations, and rapid rise in body temperature.
Description : The usual cardiovascular effect of levodopa is: A. Bradycardia due to increased vagal tone B. Rise in blood pressure due to increased noradrenaline content of adrenergic nerve endings C. Fall in blood pressure due to decrease in sympathetic tone D. Both ‘A’ and ‘B’ are correct
Last Answer : C. Fall in blood pressure due to decrease in sympathetic tone
Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level
Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened
Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects
Last Answer : D. It produces prominent extrapyramidal side effect
Description : Use of glycopyrrolate in preanaesthetic medication serves the following purposes except: A. Prevents respiratory secretions during anaesthesia B. Guards against reflex vagal bradycardia during ... Produces amnesia for perioperative events D. Reduces the probability of occurrence of laryngospasm
Last Answer : C. Produces amnesia for perioperative events
Description : In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm
Last Answer : D. Bronchospasm
Description : Stimulation of the cholinergic pathway results in: a. ciliary muscle contraction b. a decrease in atrial contractility c. gall bladder contraction d. all above
Last Answer : all above
Description : Choose the correct statement about pentazocine: A. It causes bradycardia and fall in blood pressure B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses C. It induces vomiting frequently D. It substitutes for morphine in dependent subjects
Last Answer : B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses
Description : If useful products are released from the cell. The process is called a. secretion b. excretion c. sweating d. urination
Last Answer : secretion