The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor

The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor
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D. GABA-benzodiazepine receptor
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The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor

Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor

Last Answer : D. GABA-benzodiazepine receptor

The receptor transduction mechanism with the fastest time-course of response effectuation is: A. Adenylyl cyclase-cyclic AMP pathway B. Phospholipase C-IP3: DAG pathway C. Intrinsic ion channel operation D. Protein synthesis modulation

Description : The receptor transduction mechanism with the fastest time-course of response effectuation is: A. Adenylyl cyclase-cyclic AMP pathway B. Phospholipase C-IP3: DAG pathway C. Intrinsic ion channel operation D. Protein synthesis modulation

Last Answer : C. Intrinsic ion channel operation

The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor

Description : The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor

Last Answer : D. G protein coupled receptor

The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the benzodiazepine receptor C. Increase the frequency of chloride channel opening without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions

Description : The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the ... without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions

Last Answer : D. Have both GABA-facilitatory as well as GABA-mimetic actions

Muscarinic cholinergic receptors: A. Are located only on parasympathetically innervated effector cells B. Mediate responses by opening an intrinsic Na+ ion channel C. Are present on vascular endothelium which has no cholinergic nerve supply D. Predominate in the autonomic ganglia

Description : Muscarinic cholinergic receptors: A. Are located only on parasympathetically innervated effector cells B. Mediate responses by opening an intrinsic Na+ ion channel C. Are present on vascular endothelium which has no cholinergic nerve supply D. Predominate in the autonomic ganglia

Last Answer : C. Are present on vascular endothelium which has no cholinergic nerve supply

Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Description : Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Last Answer : C. Tyrosine protein kinase receptors

Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign

Description : Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign

Last Answer : C. Affinity and intrinsic activity with a + sign

Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an ‘all or none’ action on a receptor C. Receptor and drugs acting on it have rigid complementary ‘lock and key’ structural features D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable

Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign

Description : Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign

Last Answer : C. Affinity and intrinsic activity with a + sign

Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an ‘all or none’ action on a receptor C. Receptor and drugs acting on it have rigid complementary ‘lock and key’ structural features D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable

Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

Agonistic action on which of the following adrenergic receptors located on ciliary epithelial cells reduces aqueous secretion: A. β1 receptor B. β2 receptor C. α1 receptor D. α2 receptor

Description : Agonistic action on which of the following adrenergic receptors located on ciliary epithelial cells reduces aqueous secretion: A. β1 receptor B. β2 receptor C. α1 receptor D. α2 receptor

Last Answer : D. α2 receptor

The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP

Description : The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP

Last Answer : C. Is insensitive to blockade by bicuculline

The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor

Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists

Last Answer : D. Disposal of agonists and antagonists

The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam: A. Picrotoxin B. Muscimol C. Flumazenil D. Bicuculline

Description : The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam: A. Picrotoxin B. Muscimol C. Flumazenil D. Bicuculline

Last Answer : D. Bicuculline

The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam: A. Picrotoxin B. Muscimol C. Flumazenil D. Bicuculline

Description : The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam: A. Picrotoxin B. Muscimol C. Flumazenil D. Bicuculline

Last Answer : D. Bicuculline

The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor

Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor

Last Answer : Ans: B

Which of the following is a selective H1 receptor agoinist ? (a) 4-methyl histamine (b) Impromidine (c) 2-Thiazolyl ethylamine (d) Mepyramine

Description : Which of the following is a selective H1 receptor agoinist ? (a) 4-methyl histamine (b) Impromidine (c) 2-Thiazolyl ethylamine (d) Mepyramine

Last Answer : Ans: C

Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Description : Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Last Answer : C. 2-Thiazolyl ethylamine

The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above

Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above

Last Answer : C. Leukotriene ( cys LT1) receptor antagonists

The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor

Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor

Last Answer : B. Serotonin

Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Description : Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Last Answer : C. 2-Thiazolyl ethylamine

Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above

Description : Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above

Last Answer : Ans: B

Fall in blood pressure caused by larger doses of histamine is blocked by (a) H1 antihistaminics alone (b) H2 ANTAgonists alone (c) Combination of H1 and H2 antagonists (d) None of the above

Description : Fall in blood pressure caused by larger doses of histamine is blocked by (a) H1 antihistaminics alone (b) H2 ANTAgonists alone (c) Combination of H1 and H2 antagonists (d) None of the above

Last Answer : Ans: C

Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above

Description : Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above

Last Answer : C. Combination of H1 and H2 antagonists

Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above

Description : Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above

Last Answer : C. Combination of H1 and H2 antagonists

The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

Description : The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

Last Answer : A. Baclofen

Which of the following statements is not true of zopiclone: A. It is a nonbenzodiazepine hypnotic with efficacy and safety similar to benzodiazepines B. It does not produce rebound sleep disturbances on discontinuation C. It does not act by potentiating GABA D. It is used to wean off insomniacs from regular benzodiazepine use

Description : Which of the following statements is not true of zopiclone: A. It is a nonbenzodiazepine hypnotic with efficacy and safety similar to benzodiazepines B. It does not produce rebound sleep disturbances ... act by potentiating GABA D. It is used to wean off insomniacs from regular benzodiazepine use

Last Answer : C. It does not act by potentiating GABA

In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm

Description : In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm

Last Answer : D. Bronchospasm

The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because: A. Both are physiologically present in the body B. They act on physiological receptors C. Both affect many physiological processes D. They have opposite physiological effects

Description : The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because: A. Both are physiologically present in the body B. They act on physiological receptors C. Both affect many physiological processes D. They have opposite physiological effects

Last Answer : D. They have opposite physiological effects

The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because: A. Both are physiologically present in the body B. They act on physiological receptors C. Both affect many physiological processes D. They have opposite physiological effects

Description : The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because: A. Both are physiologically present in the body B. They act on physiological receptors C. Both affect many physiological processes D. They have opposite physiological effects

Last Answer : D. They have opposite physiological effects

A partial agonist can antagonise the effects of a full agonist because it has: A. High affinity but low intrinsic activity B. Low affinity but high intrinsic activity C. No affinity and low intrinsic activity D. High affinity but no intrinsic activity

Description : A partial agonist can antagonise the effects of a full agonist because it has: A. High affinity but low intrinsic activity B. Low affinity but high intrinsic activity C. No affinity and low intrinsic activity D. High affinity but no intrinsic activity

Last Answer : A. High affinity but low intrinsic activity

A partial agonist can antagonise the effects of a full agonist because it has: A. High affinity but low intrinsic activity B. Low affinity but high intrinsic activity C. No affinity and low intrinsic activity D. High affinity but no intrinsic activity

Description : A partial agonist can antagonise the effects of a full agonist because it has: A. High affinity but low intrinsic activity B. Low affinity but high intrinsic activity C. No affinity and low intrinsic activity D. High affinity but no intrinsic activity

Last Answer : A. High affinity but low intrinsic activity

Beta adrenergic blockers lower intraocular tension by: A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors B. Constricting ciliary blood vessels C. Blocking adrenergic action on trabecular meshwork D. Reducing aqueous formation unrelated to beta adrenoceptor mediation

Description : Beta adrenergic blockers lower intraocular tension by: A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors B. Constricting ciliary blood vessels ... action on trabecular meshwork D. Reducing aqueous formation unrelated to beta adrenoceptor mediation

Last Answer : A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors

Currently, the first choice drug for open angle glaucoma is: A. Miotic eye drops B. Ocular α2 adrenergic agonists C. Ocular prostaglandin analogues D. Ocular β adrenergic blockers

Description : Currently, the first choice drug for open angle glaucoma is: A. Miotic eye drops B. Ocular α2 adrenergic agonists C. Ocular prostaglandin analogues D. Ocular β adrenergic blockers

Last Answer : D. Ocular β adrenergic blockers

The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor

Description : The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor

Last Answer : C. Suppression of maximal agonist response

A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor

Description : A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor

Last Answer : A. Insulin receptor

What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptoR

81. Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus) (1) Cortisol, testosterone (2) Insulin, glucagon (3) Thyroxin, Insulin (4) Somatostatin, oxytocin

Description : 81. Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus) (1) Cortisol, testosterone (2) Insulin, glucagon (3) Thyroxin, Insulin (4) Somatostatin, oxytocin

Last Answer : Cortisol, testosterone

Cholinergic muscarinic receptor stimulation produces the following effects except: A. Sweating B. Rise in blood pressure C. Bradycardia D. Urination

Description : Cholinergic muscarinic receptor stimulation produces the following effects except: A. Sweating B. Rise in blood pressure C. Bradycardia D. Urination

Last Answer : B. Rise in blood pressure

The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor

Description : The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor

Last Answer : C. Suppression of maximal agonist response

A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor

Description : A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor

Last Answer : A. Insulin receptor

All of the following subserve as intracellular second messengers in receptor mediated signal transduction except: A. Cyclic AMP B. Inositol trisphosphate C. Diacyl glycerols D. G proteins

Description : All of the following subserve as intracellular second messengers in receptor mediated signal transduction except: A. Cyclic AMP B. Inositol trisphosphate C. Diacyl glycerols D. G proteins

Last Answer : D. G proteins

Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor

Description : Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor

Last Answer : B. Steroid receptor

Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor

Description : Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor

Last Answer : A. Muscarinic cholinergic receptor

Agonists affect the receptor molecule in the following manner: A. Alter its amino acid sequence B. Denature the receptor protein C. Alter its folding or alignment of subunits D. Induce covalent bond formation

Description : Agonists affect the receptor molecule in the following manner: A. Alter its amino acid sequence B. Denature the receptor protein C. Alter its folding or alignment of subunits D. Induce covalent bond formation

Last Answer : C. Alter its folding or alignment of subunits

What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptor

A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

Description : A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

Last Answer : C. Corticosteroid

Procainamide differs from quinidine in the following respect (a) It does not cause paradoxical tachycardia (b) It has no alfa adrenergic blocking activity (c) It has little antivagal action (d) Both (b) and (c) Ans: D 68. In heart, potassium channels determine (a) Pacemaker function (b) Resting potential (c) Action potential duration (d) All of the above

Description : Procainamide differs from quinidine in the following respect (a) It does not cause paradoxical tachycardia (b) It has no alfa adrenergic blocking activity (c) It has little antivagal action (d) Both (b ... a) Pacemaker function (b) Resting potential (c) Action potential duration (d) All of the above

Last Answer : Ans: D

Insulin release from pancreatic β cells is augmented by the following except: A. Ketone bodies B. Glucagon C. Vagal stimulation D. Alfa adrenergic agonists

Description : Insulin release from pancreatic β cells is augmented by the following except: A. Ketone bodies B. Glucagon C. Vagal stimulation D. Alfa adrenergic agonists

Last Answer : D. Alfa adrenergic agonist

elect the drug which relieves anxiety but neither reacts with benzodiazepine receptor nor produces any overt CNS effect: A. Oxazepam B. Thioproperazine C. Buspirone D. Chlordiazepoxide

Description : elect the drug which relieves anxiety but neither reacts with benzodiazepine receptor nor produces any overt CNS effect: A. Oxazepam B. Thioproperazine C. Buspirone D. Chlordiazepoxide

Last Answer : C. Buspirone