Description : Which pressor agent acts directly as well as indirectly and produces both vasoconstriction and cardiac stimulation: A. Phenylephrine B. Methoxamine C. Noradrenaline D. Mephentermine
Last Answer : D. Mephentermine
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : Which of the following vasoactive drugs used in treating shock results in reduced preload and afterload, reducing oxygen demand of the heart? a) Nitroprusside (Nipride) A disadvantage ... increases cardiac output. d) Methoxamine (Vasoxyl) Methoxamine increases blood pressure by vasoconstriction.
Last Answer : a) Nitroprusside (Nipride) A disadvantage of nitroprusside is that it causes hypotension.
Description : While undergoing a surgical procedure a patient deve- lops hypotension. Which drug can be injected intramuscularly to raise his BP: A. Noradrenaline B. Isoprenaline C. Mephentermine D. Isoxsuprine
Last Answer : C. Mephentermine
Description : While undergoing a surgical procedure a patient develops hypotension. Which drug can be injected intramuscularly to raise his BP: A. Noradrenaline B. Isoprenaline C. Mephentermine D. Isoxsuprine
Description : Dopaminergic D1 and D2 as well as adrenergic α and β1, but not β2 receptors are activated by: A. Dopamine B. Dobutamine C. Methoxamine D. Phenylephrine
Last Answer : A. Dopamine
Description : Dopaminergic D1 and D2 as well as adrenergic α and β 1, but not β 2 receptors are activated by: A. Dopamine B. Dobutamine C. Methoxamine D. Phenylephrine
Description : The following is a pressor peptide that can be generated both in circulation as well as locally in certain tissues: A. Bradykinin B. Angiotensin C. Kallidin D. Plasmin
Last Answer : B. Angiotensin
Description : Beneficial effects of β-adrenoceptor blockers in CHF include the following except: A. Antagonism of ventricular wall stress enhancing action of sympathetic overactivity B. Antagonism ... Prevention of pathological remodeling of ventricular myocardium D. Prevention of dangerous cardiac arrhythmias
Last Answer : B. Antagonism of vasoconstriction due to sympathetic overactivity
Description : Phenylephrine instilled in the eye produces: A. Mydriasis but no cycloplegia B. Cycloplegia but no mydriasis C. Both mydriasis and cycloplegia D. Neither mydriasis nor cycloplegia
Last Answer : A. Mydriasis but no cycloplegia
Description : Depolarizing neuromuscular blockers differ from competitive blockers in the following attributes except: A. They induce contraction of isolated frog rectus abdominis muscle B. Ether anaesthesia ... produces well sustained contraction D. Neostigmine does not reverse block produced by them
Last Answer : B. Ether anaesthesia intensifies block produced by them
Description : The mechanisms involved in the causation of dangerous cardiac arrhythmias due to overdose of tricyclic antidepressants include the following except: A. Intraventricular conduction block B. Potentiation of noradrenaline C. Antagonism of acetylcholine D. Increased vagal tone
Last Answer : D. Increased vagal tone
Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings
Last Answer : A. Direct vasodilatation
Description : While undergoing a surgical procedure a patient develops hypotension. Which of the following drugs can be injected intramuscularly to raise his BP (a) Noradrenaline (b) Isoprenaline (c) Mephentermine (d) Isoxsuprine
Last Answer : Ans: C
Description : True statements concerning hypoadrenal shock include which of the following? A. Adrenocortical insufficiency may manifest itself as severe shock refractory to volume and pressor therapy. B. ... test should be performed to help establish the diagnosis of acute adrenocortical insufficiency.
Last Answer : Answer: AD DISCUSSION: Shock due to acute adrenocortical insufficiency is relatively uncommon but must be considered when shock refractory to volume replacement and pressor therapy is present. ... and it is the corticosteroid of choice while the ACTH stimulation test is being performed
Description : In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm
Last Answer : D. Bronchospasm
Description : Which of the following is seen at low (analgesic) doses of aspirin: A. Respiratory stimulation B. Increased occult blood loss in stools C. Increased cardiac output D. Hyperglycaemia
Last Answer : B. Increased occult blood loss in stools
Description : The drug which produces vasoconstriction despite being an α adrenergic blocker is: A. Phenoxybenzamine B. Ergotamine C. Dihydroergotoxine D. Tolazoline
Last Answer : B. Ergotamine
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : Captopril pretreatment: A. Inhibits the pressor action of angiotensin I B. Inhibits the pressor action of angiotensin II C. Potentiates the depressor action of bradykinin D. Both ‘A’ and ‘C’ are correct
Last Answer : D. Both ‘A’ and ‘C’ are correct
Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop
Last Answer : C. Used alone, its effective doses produce intolerable side effect
Description : The following is true of bupropion except: A. It inhibits dopamine reuptake along with inhibiting noradrenaline reuptake B. It produces sedation as a side effect C. It is being used as an aid for smoking cessation D. It is likely to produce seizures in overdose
Last Answer : B. It produces sedation as a side effect
Description : The α2 adrenoceptors are: A. Located exclusively on the adrenergic nerve endings B. Prejunctional, postjunctional as well as extrajunctional in location C. Selectively activated by phenylephrine D. Selectively blocked by clonidine
Last Answer : B. Prejunctional, postjunctional as well as extrajunctional in location
Description : The α 2 adrenoceptors are: A. Located exclusively on the adrenergic nerve endings B. Prejunctional, postjunctional as well as extrajunctional in location C. Selectively activated by phenylephrine D. Selectively blocked by clonidine
Description : The following are true: a. heroin causes miosis by increasing the release of acetylcholine. b. botulinum toxin causes mydriasis by inhibiting the release of acetylcholine c. ... mydriasis by stimulating the alpha receptors d. amphetamine causes mydriasis by inhibiting noradrenaline reuptake
Last Answer : phenylephrine causes mydriasis by stimulating the alpha receptors
Description : The following sympathomimetic amine has agonistic action on α1 + α2 + β1 + β3 adrenoceptors, but not on β2 receptors: A. Adrenaline B. Noradrenaline C. Isoprenaline D. Phenylephrine
Last Answer : B. Noradrenaline
Description : The following sympathomimetic amine has agonistic action on α 1 + α 2 + β 1 + β 3 adrenoceptors, but not on β 2 receptors: A. Adrenaline B. Noradrenaline C. Isoprenaline D. Phenylephrine
Description : Histamine causes all the following except (A) Stimulation of gastric secretion (B) Vasoconstriction (C) Pruritus (D) Increase in capillary permeability
Last Answer : Answer : B
Description : Stimulation of the beta receptors give rise to: a. tachycardia b. increased myocardial contraction c. vasoconstriction of visceral vessels d. pupil dilatation
Last Answer : increased myocardial contraction
Description : Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial stimulation ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release
Last Answer : C. Initial stimulation followed by inhibition of gonadotropin release after 1-2 weeks
Description : 16.17 Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release
Description : The vasopressin action(s) mediated by V2 receptors include(s): A. Increased water permeability of collecting duct cells B. Increased urea permeability of collecting duct cells C. Vasoconstriction D. Both 'A' and 'B
Last Answer : D. Both 'A' and 'B
Description : The following is true of clarithromycin except: A. It produces less gastric irritation and pain than erythromycin B. It is the most active macrolide antibiotic against Helicobacter pylori ... terfenadine or cisapride to cause cardiac arrhythmias D. It exhibits dose dependent elimination kinetics
Last Answer : C. It does not interact with terfenadine or cisapride to cause cardiac arrhythmias
Description : The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently ... suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines
Last Answer : D. It does not block neuronal uptake of biogenic amines
Description : Choose the correct statement about aspirin: A. In an afebrile patient acute overdose of aspirin produces hypothermia B. Aspirin suppresses flushing attending large dose of nicotinic acid C. Aspirin ... acute rheumatic fever D. Long term aspirin therapy increases the risk of developing colon cancer
Last Answer : B. Aspirin suppresses flushing attending large dose of nicotinic acid
Description : The following mydriatic does not produce cycloplegia: A. Phenylephrine B. Tropicamide C. Cyclopentolate D. Homatropine
Last Answer : A. Phenylephrine
Description : Lignocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because: A. It has a rapidly developing and titratable antiarrhythmic action B. It causes ... atrial as well as ventricular arrhythmias D. Both A' and B' are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : In post-myocardial infarction and other high cardiovascular risk subjects but without hypertension or heart failure, prolonged ACE inhibitor medication has been found to: A. Increase the chances of sudden cardiac death ... Lower the risk of developing heart failure and diabetes D. Both B and C'
Last Answer : D. Both ‘B‘ and ‘C
Description : Which of the following statements regarding the complement system are true? a. Complement activation yields products which are directly cytotoxic as well as products which act indirectly via activated ... and classical pathways converge proximal to generating the membrane attack complex (C5b-9)
Last Answer : Answer: a, d The complement system is composed of two different but linked sequences, the classic and alternative pathways. The pathways involve serum proteins that act to amplify the inflammatory-immune ... the C5 level proximal to generating the membrane attack complex (C5b-9) (Figure 6-3)
Description : The usual cardiovascular effect of levodopa is: A. Bradycardia due to increased vagal tone B. Rise in blood pressure due to increased noradrenaline content of adrenergic nerve endings C. Fall in blood pressure due to decrease in sympathetic tone D. Both ‘A’ and ‘B’ are correct
Last Answer : C. Fall in blood pressure due to decrease in sympathetic tone
Description : Ropinirole differs from bromocriptine in the following respect: A. It does not directly activate dopamine D2 receptors B. It produces milder gastrointestinal side effects C. In early cases of parkinsonism, it is less likely to need levodopa supplementation D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : Which of the following statement(s) is/are correct concerning the cardiovascular response to shock? a. Changes in cardiac contractile function shift the Frank Starling curve up and down b. ... d. The total circulating blood volume is equally split between the arterial and venous system
Last Answer : Answer: a Central in the general cardiovascular response to shock is the action of the heart itself. The principle determinants of cardiac function in the normal heart are the volume of blood ... Blood flow to the skin is sacrificed early, followed by that to the kidneys and splanchnic viscera
Description : Angiotensin III is equipotent to angiotensin II in: A. Releasing aldosterone from adrenal cortex B. Promoting Na+ and water reabsorption by direct intrarenal action C. Causing vasoconstriction D. Contracting intestinal smooth muscle
Last Answer : A. Releasing aldosterone from adrenal cortex
Description : Angiotensin II causes rise in blood pressure by: A. Direct vasoconstriction B. Releasing adrenaline from adrenal medulla C. Increasing central sympathetic tone D. All of the above
Last Answer : D. All of the above
Description : Ergometrine stops postpartum haemorrhage by: A. Causing vasoconstriction of uterine arteries B. Increasing tone of uterine muscle C. Promoting coagulation D. Inducing platelet aggregation
Last Answer : B. Increasing tone of uterine muscle