answer:I’ve been taking Effexor (venlafaxine) for about 5 years now. I have indeed noticed a huge difference in my overall mood, as well as my ability to step back and evaluate stressful situations before reacting. It’s helped a lot with anxiety as well. As for side effects, my appetite decreased in the first year or so I was on it. I lost about 30lbs, but as I was overweight anyway, it wasn’t a bad thing. I also need more sleep than I used to – when I started taking the Effexor, I took it in the mornings and was ready for bed around 9pm. Most days I’m able to incorporate a nap into my schedule, though, so I’ve been able to work around that. If I don’t take my meds within a couple of hours of my usual time, I get the shakes. Nothing big – the side effects weren’t anything I had any real problems with. Hope it works for you.