Yes. Too much advil (or ibuprofen) can result in gastritis (irritation of the stomach lining) or kidney failure if taken at high doses or for an extended period of time. Gastritis is the most common serious side effect, and kidney damage tends to occur to people who already have some mild kidney disease or other conditions that lead to poor blood flow to the kidneys. Here is a list of some of the side effects attributed to ibuprofen. Basically, it depends on how much you take and for how long. A week or two of ibuprofen every 8 hours is most likely safe if you are otherwise healthy. However, taking ibuprofen for months or years has the potential to be more dangerous. At minimum, you should take it with food to try and minimize the risk of gastritis.