answer:Yes. I don’t take it anymore, but when I did I noticed certain things people said set me off like they never did before. My father playfully insulted me once and I had to excuse myself from the room I was so pissed at him, like punching inanimate objects level pissed. I also noticed that I found myself being more ‘daring’ with what I said, meaning I exercised less discretion with what I vocalized. A bit of a “I don’t care what the repercussions are because this is how I feel at the moment” approach. Interestingly, this only happened the first time I took it (which lasted maybe a year). I went off anti-depressants for a few years, but when I decided to resume them I tried Wellbutrin again and didn’t have any of these negative side effects…as a matter of fact, the 2nd time I tried it I stopped because it didn’t do anything for me, good or bad. Hehe, thinking back now, I believe the first time I took Wellbutrin my dosage was too high…pretty sure I was at max dose. If a person can manage the anger issues often associated with it I think it’s a good medication. There generally aren’t any negative side effects (unless you consider increased libido and decreased appetite to be negative).