Which of the following suggests a diagnosis of Hurler's Syndrome rather than Hunter's Syndrome? 1) X-linked inheritance 2) Mental retardation 3) Skeletal abnormalities 4) Cloudy cornea 5) Cardiomyopathy

Which of the following suggests a diagnosis of Hurler's Syndrome rather than Hunter's Syndrome? 1) X-linked inheritance 2) Mental retardation 3) Skeletal abnormalities 4) Cloudy cornea 5) Cardiomyopathy
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Answers-4 Hunter's Syndrome (MPS-2) is of X-linked inheritance. The cornea are clear. The skeletal involvement tends to be mild with no gibbous present, though scoliosis is often found. Mental retardation and heart involvement are less severe than in Hurler's Syndrome. Hurler's Syndrome (MPS0) is autosomal recessive in inheritance and is associated with cloudy cornea. There is severe mental retardation, and gibbous deformation of the spine is characteristic. There is the characteristic coarse facies with hepatosplenomegaly.
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