Slow reacting Substance of Anaphylaxis is a mixture of (A) Prostaglandins (B) Prostacyclins (C) Thromboxanes (D) Leukotrienes

Slow reacting Substance of Anaphylaxis is a mixture of (A) Prostaglandins (B) Prostacyclins (C) Thromboxanes (D) Leukotrienes
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Which of the following is used for inducing labour? (A) Prostaglandins (B) Prostacyclins (C) Vasopressin (D) Thromboxanes

Description : Which of the following is used for inducing labour? (A) Prostaglandins (B) Prostacyclins (C) Vasopressin (D) Thromboxanes

Last Answer : Answer : A

Aspirin blocks the synthesis of (A) Prostaglandins only (B) Prostacyclins only (C) Thromboxanes only (D) All of these

Description : Aspirin blocks the synthesis of (A) Prostaglandins only (B) Prostacyclins only (C) Thromboxanes only (D) All of these

Last Answer : Answer : D

Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these

Description : Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these

Last Answer : Answer : B

Anti-inflammatory corticosteroids inhibit the synthesis of (A) Leukotrienes (B) Prostaglandins (C) Thromboxanes (D) All of these

Description : Anti-inflammatory corticosteroids inhibit the synthesis of (A) Leukotrienes (B) Prostaglandins (C) Thromboxanes (D) All of these

Last Answer : Answer : D

Eicosanoids mediate inflammation in a variety of ways. Of the following statements, which are true with regard to this? a. Eicosanoids are stored in cytoplasmic granules for release after receptor mediated signaling b. Eicosanoids include prostaglandins, thromboxanes, leukotrienes and lipoxins c. Eicosanoids generally have a plasma half-life measured in hours d. Physiologic responses to eicosanoids include vasodilatation, vasoconstriction, increased vascular permeability and both chemotaxis and chemoattractant inhibition

Description : Eicosanoids mediate inflammation in a variety of ways. Of the following statements, which are true with regard to this? a. Eicosanoids are stored in cytoplasmic granules ... include vasodilatation, vasoconstriction, increased vascular permeability and both chemotaxis and chemoattractant inhibition

Last Answer : Answer: b, d The eicosanoids are derived from arachidonic acid (eicosatetraenoic acid) and consist of prostaglandins, thromboxanes, leukotrienes and lipoxins. The eicosanoids are not ... nervous system d. Mononuclear phagocytes release a variety of proinflammatory cytokines and growth factors

Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these

Description : Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, and bronchoconstricting effects of thromboxane A 2 are balanced by the actions of prostacyclin, which produces the opposite effects. C. Leukotriene synthesis is inhibited by the action of nonsteroidal anti-inflammatory drugs (NSAIDs). D. The principal prostaglandins have a short circulation half-life and exert most of their effects locally.

Description : True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, ... prostaglandins have a short circulation half-life and exert most of their effects locally.

Last Answer : Answer: ABD DISCUSSION: The eicosanoids are a group of compounds arising from the metabolism of arachidonic acid. The prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase ... effects and may be involved in the physiologic responses associated with anaphylactic and septic shock

Cyclooxygenase-1 and –2 are responsible for (a) The synthesis of prostaglandins from arachidonate (b) The synthesis of leukotrienes from arachidonate (c) The conversion of ATP to cAMP (d) The metabolic degradation of cAMP (e) The conversion of GTP to cGMP

Description : Cyclooxygenase-1 and –2 are responsible for (a) The synthesis of prostaglandins from arachidonate (b) The synthesis of leukotrienes from arachidonate (c) The conversion of ATP to cAMP (d) The metabolic degradation of cAMP (e) The conversion of GTP to cGMP

Last Answer : Ans: A

Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) Cyclooxygenase 1 (b) Cyclooxygenase 2 (c) Glutathione – S – transferase (d) Lipoxygenase (e) Phospholipase A2

Description : Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) ... 2 (c) Glutathione - S - transferase (d) Lipoxygenase (e) Phospholipase A2

Last Answer : Ans: B

Explain in brief about leukotrienes and prostaglandins Leukotrienes and prostaglandins are formed only when the mast cell undergo degranulation and enzymatic break down of phospholipids in the plasma membrane ?

Description : Explain in brief about leukotrienes and prostaglandins Leukotrienes and prostaglandins are formed only when the mast cell undergo degranulation and enzymatic break down of phospholipids in the plasma membrane ?

Last Answer : The effects produced by them are more pronounced and long lasting than histamine. Leukotrienes mediate mucous production and bronchoconstriction. Prostaglandin D2 causes bronchoconstriction.

There are no preformed stores of the following autacoid/autacoids: A. Prostaglandins B. Leukotrienes C. Angiotensin II D. All of the above

Description : There are no preformed stores of the following autacoid/autacoids: A. Prostaglandins B. Leukotrienes C. Angiotensin II D. All of the above

Last Answer : D. All of the above

Systemic _____ is the most dangerous form of a Type I Hypersensitivity. a. Anaphylaxis b. Unconsciousness c. Edema d. Prostaglandins

Description : Systemic _____ is the most dangerous form of a Type I Hypersensitivity. a. Anaphylaxis b. Unconsciousness c. Edema d. Prostaglandins

Last Answer : a. Anaphylaxis

A 60-year-old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure? (a) Leukotriene LTD4 or its analogs (b) Prostaglandin E2 or its analogs (c) Prostaglandin F2a or its analogs (d) Slow-reacting substance of anaplylaxis (SRS-A) (e) Thromboxane A2 or its analogs

Description : A 60-year-old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure? (a) Leukotriene LTD4 or its analogs (b) Prostaglandin E2 or its analogs ( ... analogs (d) Slow-reacting substance of anaplylaxis (SRS-A) (e) Thromboxane A2 or its analogs

Last Answer : Ans: C

One of the important functions of prostacyclins is (A) Inhibition of platelet aggregation (B) Contraction of uterus (C) Decrease of gastric secretion (D) Relieving osthma

Description : One of the important functions of prostacyclins is (A) Inhibition of platelet aggregation (B) Contraction of uterus (C) Decrease of gastric secretion (D) Relieving osthma

Last Answer : Answer : A

Prostaglandins are derived from what substance?

Description : Prostaglandins are derived from what substance?

Last Answer : Prostaglandins are derived from the PUFA. The Series 2 (with two double bonds) are derived from arachidonic acid. All naturally occurring PGs belong to the 2-series.

In allergic reaction: a. Arthus reaction is a type IV reaction b. anaphylaxis occurs in patients who have had no previous exposure to the offending substance c. contact dermatitis is a type IV reaction d. positive Mantoux test is a type III reaction

Description : In allergic reaction: a. Arthus reaction is a type IV reaction b. anaphylaxis occurs in patients who have had no previous exposure to the offending substance c. contact dermatitis is a type IV reaction d. positive Mantoux test is a type III reaction

Last Answer : contact dermatitis is a type IV reaction

Thromboxanes cause (A) Vasodilation (B) Bronchoconstriction (C) Platelet aggregation (D) All of these

Description : Thromboxanes cause (A) Vasodilation (B) Bronchoconstriction (C) Platelet aggregation (D) All of these

Last Answer : Answer : C

Leukotrienes cause (A) Increase in capillary permeability (B) Aggregation of platelets (C) Bronchodilatation (D) None of these

Description : Leukotrienes cause (A) Increase in capillary permeability (B) Aggregation of platelets (C) Bronchodilatation (D) None of these

Last Answer : Answer : A

Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion

Description : Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion

Last Answer : Answers-5 Leukotrienes are synthesized by leucocytes.They are mediators of allergic reaction. They increase vascular permeability and attract neutrophils and eosinophils to inflammatory sites. ... stimulate mucus production, an important consideration in the pathophysiology of bronchial asthma.

What is the precursor of leukotrienes?

Description : What is the precursor of leukotrienes?

Last Answer : They are produced from arachidonic acid.

Pick out the wrong statement. (A) The mole fraction of solute is directly proportional to the molality of a 'dilute' solution (B) For a non-reacting binary mixture of ideal gases, the partial pressure distribution of both components is nonlinear in the case of steady state unimolal unidirectional diffusion (C) Azeotropes obey Raoult's law at all temperature (D) The relative volatility of a binary mixture at the Azeotropic composition is 1

Description : Pick out the wrong statement. (A) The mole fraction of solute is directly proportional to the molality of a 'dilute' solution (B) For a non-reacting binary mixture of ideal gases, the partial ... at all temperature (D) The relative volatility of a binary mixture at the Azeotropic composition is 1

Last Answer : (C) Azeotropes obey Raoult's law at all temperature

Pick out the correct statement. (A) Higher hold up of the solid in the rotary dryer results in better exposure of the solids to the gas (B) The 'Hatta number' is important in problems involving gas absorption without chemical reaction (C) For a non-reacting binary mixture of ideal gases, the partial pressure distribution of both components is linear in the case of steady state equimolal counter-diffusion (D) Total reflux in case of distillation operation requires infinite number of plates for a binary system separation

Description : Pick out the correct statement. (A) Higher hold up of the solid in the rotary dryer results in better exposure of the solids to the gas (B) The 'Hatta number' is ... reflux in case of distillation operation requires infinite number of plates for a binary system separation

Last Answer : (C) For a non-reacting binary mixture of ideal gases, the partial pressure distribution of both components is linear in the case of steady state equimolal counter-diffusion

A second order liquid phase reaction, A → B, is carried out in a mixed flow reactor operated in semi batch mode (no exit stream). The reactant A at concentration CAF is fed to the reactor at a volumetric flow rate of F. The volume of the reacting mixture is V and the density of the liquid mixture is constant. The mass balance for A is (A) d(VCA )/dt = -F (CAF - CA ) - kCA 2V (B) d(VCA )/dt = F (CAF - CA ) - kCA 2V (C) d(VCA )/dt = -FCA - kCA 2V (D) d(VCA )/dt = FCAF - kCA 2V

Description : A second order liquid phase reaction, A → B, is carried out in a mixed flow reactor operated in semi batch mode (no exit stream). The reactant A at concentration CAF is fed to the reactor at a volumetric flow rate of F. The volume ... 2V (C) d(VCA )/dt = -FCA - kCA 2V (D) d(VCA )/dt = FCAF - kCA 2V

Last Answer : (D) d(VCA )/dt = FCAF - kCA 2V

“The total volume of a mixture of non-reacting gases is equal to the sum of the partial volumes.” This statement is known as ______.  A. Law of Dulong and Petit  B. Maxwell-Boltzmann law  C. Amagat’s law  D. Avogadro’s law

Description : “The total volume of a mixture of non-reacting gases is equal to the sum of the partial volumes.” This statement is known as ______.  A. Law of Dulong and Petit  B. Maxwell-Boltzmann law  C. Amagat’s law  D. Avogadro’s law

Last Answer : Amagat’s law

Half life period of a chemical reaction is (A) The time required to reduce the concentration of the reacting substance to half its initial value (B) Half of the space time of a reaction (C) Half of the residence time of a reaction (D) None of these

Description : Half life period of a chemical reaction is (A) The time required to reduce the concentration of the reacting substance to half its initial value (B) Half of the space time of a reaction (C) Half of the residence time of a reaction (D) None of these

Last Answer : (A) The time required to reduce the concentration of the reacting substance to half its initial value

"The rate at which a substance reacts is proportional to its active mass and the rate of a chemical reaction is proportional to the product of active masses of the reacting substances". This is the (A) Lewis-Randall rule (B) Statement of Van't Hoff Equation (C) Le-Chatelier's principle (D) None of these

Description : "The rate at which a substance reacts is proportional to its active mass and the rate of a chemical reaction is proportional to the product of active masses of the reacting substances". This is the (A) Lewis- ... (B) Statement of Van't Hoff Equation (C) Le-Chatelier's principle (D) None of these

Last Answer : (D) None of these

The activity of kinins is modulated by (A) Prostaglandins (B) Ca++ (C) Increased cAMP level (D) Increased cGMP level

Description : The activity of kinins is modulated by (A) Prostaglandins (B) Ca++ (C) Increased cAMP level (D) Increased cGMP level

Last Answer : Answer : A

Which one of the following hormones is derived most completely from tyrosine? (A) Glucagon (B) Thyroxine (C) Insulin (D) Prostaglandins

Description : Which one of the following hormones is derived most completely from tyrosine? (A) Glucagon (B) Thyroxine (C) Insulin (D) Prostaglandins

Last Answer : Answer : B

A cup of strong coffee would be expected to (A) Interfere with synthesis of prostaglandins (B) Decrease the effects of Glucagon (C) Enhance the effects of epinephrine (D) Provide the vitamin nicotinic acid

Description : A cup of strong coffee would be expected to (A) Interfere with synthesis of prostaglandins (B) Decrease the effects of Glucagon (C) Enhance the effects of epinephrine (D) Provide the vitamin nicotinic acid

Last Answer : Answer : C

The suffix number in the names of prostaglandins gives the number of (A) OH groups (B) Double bonds (C) Acid groups (D) Ketoacids

Description : The suffix number in the names of prostaglandins gives the number of (A) OH groups (B) Double bonds (C) Acid groups (D) Ketoacids

Last Answer : Answer : B

Which of tne of the following scientists has not worked in the field of prostaglandins? (A) Voneuler (B) Sultan Karim (C) Andre robet (D) Kendal

Description : Which of tne of the following scientists has not worked in the field of prostaglandins? (A) Voneuler (B) Sultan Karim (C) Andre robet (D) Kendal

Last Answer : Answer : D

Prostaglandins are (A) C2 unsaturated acids (B) C27 saturated alcohols (C) C20 saturated acids (D) C27 saturated alcohols

Description : Prostaglandins are (A) C2 unsaturated acids (B) C27 saturated alcohols (C) C20 saturated acids (D) C27 saturated alcohols

Last Answer : Answer : A

Which of the following property of prostaglandins has been utilized by chinicians in hospital for (A) Inducing fever (B) Causing inflammation (C) Effecting smooth muscle contraction (D) Disaggregation of spermatozoa

Description : Which of the following property of prostaglandins has been utilized by chinicians in hospital for (A) Inducing fever (B) Causing inflammation (C) Effecting smooth muscle contraction (D) Disaggregation of spermatozoa

Last Answer : Answer : C

Richest source of prostaglandins in a human male is (A) Blood (B) Urine (C) Semen (D) C.S.F.

Description : Richest source of prostaglandins in a human male is (A) Blood (B) Urine (C) Semen (D) C.S.F.

Last Answer : Answer : C

A cup of strong coffee would be expected to (A) Interfere with the synthesis of prostaglandins (B) Decrease the effect of glucagon (C) Enhance the effect of epinephrine (D) Provide the vitamin nicotinic acid

Description : A cup of strong coffee would be expected to (A) Interfere with the synthesis of prostaglandins (B) Decrease the effect of glucagon (C) Enhance the effect of epinephrine (D) Provide the vitamin nicotinic acid

Last Answer : Answer : C

From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase

Description : From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase

Last Answer : Answer : A

Cholesterol is the precursor for the biosynthesis of (A) fatty acid (B) prostaglandins (C) bile acids (D) sphingmyelin

Description : Cholesterol is the precursor for the biosynthesis of (A) fatty acid (B) prostaglandins (C) bile acids (D) sphingmyelin

Last Answer : Answer : C

Acrolein Test is positive for (A) Glycerol (B) Prostaglandins (C) Carbohydrates (D) Proteins

Description : Acrolein Test is positive for (A) Glycerol (B) Prostaglandins (C) Carbohydrates (D) Proteins

Last Answer : Answer : A

All the following are functions of prostaglandins except (A) Lowering of B.P (B) Introduction of labour (C) Anti inflammatory (D) Prevention of myocardial infraction

Description : All the following are functions of prostaglandins except (A) Lowering of B.P (B) Introduction of labour (C) Anti inflammatory (D) Prevention of myocardial infraction

Last Answer : Answer : D

Prostaglandins are synthesized in the body from (A) Myristic acid (B) Arachidonic acid (C) Stearic acid (D) Lignoceric acid

Description : Prostaglandins are synthesized in the body from (A) Myristic acid (B) Arachidonic acid (C) Stearic acid (D) Lignoceric acid

Last Answer : Answer : D

All active prostaglandins have atleast one double bond between positions: (A) 7 and 8 (B) 9 and 10 (C) 11 and 12 (D) 13 and 14 FATS AND FATTY ACID METABOLISM 95

Description : All active prostaglandins have atleast one double bond between positions: (A) 7 and 8 (B) 9 and 10 (C) 11 and 12 (D) 13 and 14 FATS AND FATTY ACID METABOLISM 95

Last Answer : Answer : A

Prostaglandins have a common structure based on prostanoic acid which contains carbon atoms: (A) 12 (B) 16 (C) 18 (D) 20

Description : Prostaglandins have a common structure based on prostanoic acid which contains carbon atoms: (A) 12 (B) 16 (C) 18 (D) 20

Last Answer : Answer : D

Prostaglandins are liberated in the circulation by the stimulation of (A) Anterior pituitary glands (B) Posterior pituitary glands (C) Adrenal gland (D) Thyroid gland

Description : Prostaglandins are liberated in the circulation by the stimulation of (A) Anterior pituitary glands (B) Posterior pituitary glands (C) Adrenal gland (D) Thyroid gland

Last Answer : Answer : C

The prostaglandins are synthesized from (A) Arachidonic acid (B) Oleic acid (C) Linoleic acid (D) Linolenic acid

Description : The prostaglandins are synthesized from (A) Arachidonic acid (B) Oleic acid (C) Linoleic acid (D) Linolenic acid

Last Answer : Answer : A

Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation

Description : Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation

Last Answer : Answer : C

Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion

Description : Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion

Last Answer : Answer : C

Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these

Description : Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these

Last Answer : Answer : A

Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Description : Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Last Answer : Answer : D

Prostaglandins lower camp in (A) Adipose tissue (B) Lungs (C) Platelets (D) Adenohypophysis

Description : Prostaglandins lower camp in (A) Adipose tissue (B) Lungs (C) Platelets (D) Adenohypophysis

Last Answer : Answer : A