Description : All the following diuretics inhibit the carbonic anhydrase except (A) Acetazolamide (B) Bumetanide (C) Furosemide (D) Ethacrynic acid
Last Answer : Answer : D
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Last Answer : Answer : B
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : Zn is present as prosthetic group in this enzyme: (A) Carbonic anhydrase (B) Carboxy peptidase (C) Lactate dehydrogenase (D) All of these
Description : Zinc is a constituent of the enzyme: (A) Succinate dehydrogenase (B) Carbonic anhydrase (C) Mitochondrial superoxide dismutase (D) Aldolase
Description : Carbonic anhydrase enzyme has maximum turn over number (36 million). Minimum turn over number for an enzyme: (A) DNA polymerase (B) Lysozyme (C) Penicillase (D) Lactase dehydrogenase
Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide
Last Answer : Ans: A
Description : The enzyme that catalyses carbon dioxide fixation in C4 plants is (a) RuBP carboxylase (b) PEP carboxylase (c) carbonic anhydrase (d) carboxydismutase.
Last Answer : (b) PEP carboxylase
Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures
Last Answer : D. It is not effective in generalized tonic-clonic seizures
Description : The following is a competitive type of enzyme inhibitor: A. Acetazolamide B. Disulfiram C. Physostigmine D. Theophylline
Last Answer : C. Physostigmine
Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors
Last Answer : Answer : C
Description : All of the following are iron-containing enzymes except (A) Carbonic anhydrase (B) Catalase (C) Peroxidase (D) Cytochrome oxidase
Last Answer : Answer : A
Description : All of the following are zinc-containing enzymes except (A) Acid Phosphatase (B) Alkaline Phosphatase (C) Carbonic anhydrase (D) RNA polymerase
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Description : The following diuretic acts on the luminal membrane of distal tubule and collecting ducts to inhibit electrogenic Na+ reabsorption so that K+ excretion is diminished and bicarbonate excretion is enhanced: A. Xipamide B. Isosorbide C. Triamterene D. Spironolactone
Last Answer : C. Triamterene
Description : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is present in RBC. B- Minute quantities of
Last Answer : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is ... and D C. A,B,C and D D. Only A
Description : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide combine with water and is transported.
Last Answer : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide ... A is correct and statement B is wrong.
Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above
Description : With regard to the transport of carbon dioxide in blood: a. 25% of carbon dioxide is dissolved in blood b. carbonic anhydrase is found in plasma c. 50% of carbon dioxide is carried as bicarbonate d. deoxygenated haemoglobin facilitates the transport of carbon dioxide
Last Answer : deoxygenated haemoglobin facilitates the transport of carbon dioxide
Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary
Last Answer : damage to the posterior pituitary
Description : Carbonic anhydrase occurs in (a) lymphocytes (b) blood plasma (c) RBCs (d) leucocytes.
Last Answer : (c) RBCs
Description : In which one of the following enzymes, is copper necessarily associated as an activator? (a) Carbonic anhydrase (b) Tryptophanase (c) Lactic dehydrogenase (d) Tyrosinase
Last Answer : (d) Tyrosinase
Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : Which of the following statements is not true for cancer cells in relation to mutations? (a) Mutations inactivate the cell control. (b) Mutations inhibit production of telomerase. (c) Mutations in proto-oncogenes accelerate the cell cycle. (d) Mutations destroy telomerase inhibitor.
Last Answer : (b) Mutations inhibit production of telomerase
Description : Sulbactam differs from clavulanic acid in that: A. It is not a progressive inhibitor of β-lactamase B. It does not inhibit β-lactamase produced by gram negative bacilli C. It is quantitatively more potent D. It per se inhibits N.gonorrhoeae
Last Answer : D. It per se inhibits N.gonorrhoeae
Description : Choose the selective serotonin reuptake inhibitor that is less likely to inhibit CYP2D6 and CYP3A4 resulting in fewer drug interactions: A. Sertraline B. Paroxetine C. Fluoxetine D. Fluvoxamine
Last Answer : A. Sertraline
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : Name the enzyme that acts both as carboxylase at one time and oxygenase at another time. (A) PEP carboxylase (B) RuBP carboxylase (C) Carbonic anyhdrase (D) None of these
Description : Template/lock and key theory of enzyme action is supported by (A) Enzymes speed up reaction (B) Enzymes occur in living beings and speed up certain reactions (C) Enzymes determine the direction of reaction (D) Compounds similar to substrate inhibit enzyme activity
Description : Fluoride ions inhibit which enzyme?
Last Answer : Enolase.
Description : Glucose is absorbed at the luminal side of gastro intestinal cells by which mechanism?
Last Answer : Carrier mediated co-transport with sodium, named as sodium dependent glucose transporter (SGluT).
Description : Which inactivates an enzyme by occupying its active site? (A) Competitive inhibitor (B) Allosteric inhibitor (C) Non-competitive inhibitor (D) All of these
Description : A competitive inhibitor of an enzyme (A) Increases Km without affecting Vmax (B) Decreases Km without affecting Vmax (C) Increases Vmax without affecting Km (D) Decreases both Vmax and Km
Description : Which of the following statements about an enzyme exhibiting allosteric kinetics with cooperative interaction is false? (A) A plot of V-Vk [s] has a sigmaidal shape (B) An inhibitor may increase the ... Km and Vmax (D) Removal of allosteric inhibitor may result in hyperbolic V-S [s] plot
Description : A competitive inhibitor of an enzyme has which of the following properties? (A) It is frequently a feedback inhibitor (B) It becomes covalently attached to an enzyme (C) It decreases the Vmax (D) It interferes with substrate binding to the enzyme
Description : Competitive inhibition can be relieved by raising the (A) Enzyme concentration (B) Substrate concentration (C) Inhibitor concentration (D) None of these
Description : In competitive inhibition, the inhibitor (A) Competes with the enzyme (B) Irreversibly binds with the enzyme (C) Binds with the substrate (D) Competes with the substrate
Description : In non competitive enzyme activity inhibition, inhibitor (A) Increases Km (B) Decreases Km (C) Does not effect Km (D) Increases Km
Description : In competitive enzyme activity inhibition (A) The structure of inhibitor generally resembles that of the substrate (B) Inhibitor decreases apparent Km (C) Km remains unaffective (E) Inhibitor decreases Vmax without affecting Km
Description : In reversible non-competitive enzyme activity inhibition (A) Inhibitor bears structural resemblance to substrate (B) Inhibitor lowers the maximum velocity attainable with a given amount of enzyme (C) Km is increased (D) Km is decreased
Description : The kinetic effect of purely competitive inhibitor of an enzyme (A) Increases Km without affecting Vmax (B) Decreases Km without affecting Vmax (C) Increases Vmax without affecting Km (D) Decreases Vmax without affecting Km
Description : A diuretic which is an aldosterone antagonist is (A) Spironolactone (B) Ethacrynic acid (C) Acetazolamide (D) Chlorothiazide
Description : The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: A. Neostigmine B. Physostigmine C. Edrophonium D. Dyflos
Last Answer : C. Edrophonium