Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : Hyponatraemia occurs in the following condition: (A) Addison’s disease (B) Chronic renal failure (C) Severe diarrhoea (D) All of these
Last Answer : Answer : D
Description : Metabolic alkalosis occurs (A) As consequence of high intestinal obstruction (B) In central nervous system disease (C) In diarrhoea (D) In colitis
Last Answer : Answer : A
Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary
Last Answer : damage to the posterior pituitary
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : Anion gap is increased in (A) Renal tubular acidosis (B) Metabolic acidosis resulting from diarrhoea (C) Metabolic acidosis resulting from intestinal obstruction (D) Diabetic ketoacidosis
Last Answer : Answer : B
Description : Apart from diarrhoea, oral rehydration solution has been employed in: A. Severe vomiting B. Burn cases C. Heat stroke D. Both ‘B’ and ‘C
Last Answer : D. Both ‘B’ and ‘C
Description : Which of the following concerning the pH of urine is correct? 1) is a useful indicator of the acid/base balance of the blood 2) rises on a vegetarian diet 3) is determined by the concentration of ... lower than 5.5 in renal tubular acidosis 5) would be above 7.0 after prolonged and severe vomiting
Last Answer : Answers-2 c - excretion of ammonium occurs when an acid urine is produced but the pH of urine is of course determined by the concentration of H+ ions d-unable to lower the pH to ... and distal nephron and this perpetuates the metabolic alkalosis until the fluid balance is restored with IV fluids.
Description : During compensation of respiratory alkalosis, all the following changes occur except (A) Decreased secretion of hydrogen ions by renal tubules (B) Increased excretion of sodium in urine (C) Increased excretion of bicarbonate in urine (D) Increased excretion of ammonia in urine
Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation
Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.
Description : Inborn errors of urea cycle can cause all the following except (A) Vomiting (B) Ataxia (C) Renal failure (D) Mental retardation
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Description : Zn is present as prosthetic group in this enzyme: (A) Carbonic anhydrase (B) Carboxy peptidase (C) Lactate dehydrogenase (D) All of these
Description : Zinc is a constituent of the enzyme: (A) Succinate dehydrogenase (B) Carbonic anhydrase (C) Mitochondrial superoxide dismutase (D) Aldolase
Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide
Description : Carbonic anhydrase enzyme has maximum turn over number (36 million). Minimum turn over number for an enzyme: (A) DNA polymerase (B) Lysozyme (C) Penicillase (D) Lactase dehydrogenase
Description : All of the following are iron-containing enzymes except (A) Carbonic anhydrase (B) Catalase (C) Peroxidase (D) Cytochrome oxidase
Description : All of the following are zinc-containing enzymes except (A) Acid Phosphatase (B) Alkaline Phosphatase (C) Carbonic anhydrase (D) RNA polymerase
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase
Description : All the following diuretics inhibit the carbonic anhydrase except (A) Acetazolamide (B) Bumetanide (C) Furosemide (D) Ethacrynic acid
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Last Answer : Answer : C
Description : All the following changes in blood chemistry can occur in severe diarrhoea except (A) Decreased pH (B) Decreased bicarbonate (C) Increased pCO2 (D) Increased chloride WATER AND ELECTROLYTE BALANCE 287
Description : Which one of the following effects does not occur in salicylate intoxication ? (a) Hyperventilation (b) Hypothemia (c) Metabolic acidosis (d) Respiratory alkalosis (e) Tinnitus
Last Answer : Ans: B
Description : Respiratory alkalosis is caused by (A) An increase in carbonic acid fraction (B) A decrease in bicarbonic fraction (C) A decrease in the carbonic acid fraction (D) An increase in bicarbonate fraction
Description : Recurrent vomiting leads to loss of (A) Potassium (B) Chloride (C) Bicarbonate (D) All of these
Description : The following apply to use of spironolactone in CHF except: A. It is indicated only in NYHA class III/IV cases as additional drug to conventional therapy B. It affords prognostic benefit in ... by ACE inhibitors C. It helps overcome refractoriness to diuretics D. It affords rapid symptomatic relief
Last Answer : D. It affords rapid symptomatic relief
Description : Which of the following features are present in blood chemistry in uncompensated metabolic alkalosis except? (A) Increased pH (B) Increased bicarbonate (C) Normal chloride (D) Normal pCO2
Description : Salicylate poisoning can cause (A) Respiratory acidosis (B) Metabolic acidosis with normal anion gap (C) Metabolic acidosis with increased anion gap (D) Metabolic alkalosis
Description : Hypercholremia is associated with (A) Hyponatremia (B) Hypernatremia (C) Metabolic alkalosis(D) Respiratory acidosis
Description : Salicylate poisoning in early stages causes (A) Metabolic acidosis (B) Respiratory acidosis (C) Metabolic alkalosis (D) Respiratory alkalosis
Description : Morphine poisoning causes (A) Metabolic acidosis (B) Respiratory acidosis (C) Metabolic alkalosis (D) Respiratory alkalosis
Description : Meningitis and encephalitis cause (A) Metabolic alkalosis (B) Respiratory alkalosis (C) Metabolic acidosis (D) Respiratory acidosis
Description : Total CO2 is increased in (A) Respiratory acidosis (B) Metabolic alkalosis (C) Both respiratory acidosis and metabolic alkalosis (D) Respiratory alkalosis
Description : Plasma bicarbonate is increased in (A) Respiratory alkalosis (B) Metabolic alkalosis (C) Respiratory acidosis (D) Metabolic acidosis
Description : Plasma bicarbonate is decreased in (A) Respiratory alkalosis (B) Respiratory acidosis (C) Metabolic alkalosis (D) Metabolic acidosis
Description : Metabolic alkalosis is characteristically found in which of the following? 1) An infusion of sodium chloride 2) Ileostomy 3) Mineralocorticoid deficiency 4) Pyloric stenosis 5) Salicylate poisoning
Last Answer : Answers-4 Pyloric stenosis is associated with vomiting and the loss of stomach content - hence a metabolic alkalosis. Mineralocorticoid excess (Conn's syndrome) is associated with a metabolic alkalosis. ... produce a metabolic acidosis. A sodium chloride infusion is neutral and does not alter pH.
Description : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is present in RBC. B- Minute quantities of
Last Answer : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is ... and D C. A,B,C and D D. Only A
Description : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide combine with water and is transported.
Last Answer : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide ... A is correct and statement B is wrong.
Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above
Last Answer : Ans: A
Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide
Description : With regard to the transport of carbon dioxide in blood: a. 25% of carbon dioxide is dissolved in blood b. carbonic anhydrase is found in plasma c. 50% of carbon dioxide is carried as bicarbonate d. deoxygenated haemoglobin facilitates the transport of carbon dioxide
Last Answer : deoxygenated haemoglobin facilitates the transport of carbon dioxide
Description : Carbonic anhydrase occurs in (a) lymphocytes (b) blood plasma (c) RBCs (d) leucocytes.
Last Answer : (c) RBCs
Description : The enzyme that catalyses carbon dioxide fixation in C4 plants is (a) RuBP carboxylase (b) PEP carboxylase (c) carbonic anhydrase (d) carboxydismutase.
Last Answer : (b) PEP carboxylase
Description : In which one of the following enzymes, is copper necessarily associated as an activator? (a) Carbonic anhydrase (b) Tryptophanase (c) Lactic dehydrogenase (d) Tyrosinase
Last Answer : (d) Tyrosinase
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures
Last Answer : D. It is not effective in generalized tonic-clonic seizures
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor