The following diuretic acts on the luminal membrane of distal tubule and collecting ducts to inhibit electrogenic Na+ reabsorption so that K+ excretion is diminished and bicarbonate excretion is enhanced: A. Xipamide B. Isosorbide C. Triamterene D. Spironolactone

The following diuretic acts on the luminal membrane
of distal tubule and collecting ducts to inhibit
electrogenic Na+
 reabsorption so that K+
 excretion is
diminished and bicarbonate excretion is enhanced:
A. Xipamide
B. Isosorbide
C. Triamterene
D. Spironolactone
by

1 Answer

Answer :

C. Triamterene
by

Related questions

Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct

Description : Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Amiloride inhibits K+ excretion in the distal tubules and collecting ducts by blocking: A. Electrogenic K+ channels B. Electrogenic Na+ channels C. Nonelectrogenic Na+-Cl– symport D. H+K+ATPase

Description : Amiloride inhibits K+ excretion in the distal tubules and collecting ducts by blocking: A. Electrogenic K+ channels B. Electrogenic Na+ channels C. Nonelectrogenic Na+-Cl– symport D. H+K+ATPase

Last Answer : B. Electrogenic Na+ channels

Aldosterone increases Na+ reabsorption and K+ excretion in the renal collecting duct cells by: A. Inducing synthesis of Na+K+ATPase B. Inducing synthesis of amiloride sensitive Na+ channels C. Translocating Na+ channels from cytosolic site to luminal membrane D. All of the above

Description : Aldosterone increases Na+ reabsorption and K+ excretion in the renal collecting duct cells by: A. Inducing synthesis of Na+K+ATPase B. Inducing synthesis of amiloride sensitive Na+ channels C. Translocating Na+ channels from cytosolic site to luminal membrane D. All of the above

Last Answer : D. All of the above

Secretion of K+ in the late distal tubule and collecting ducts of kidney depends on: A. Intracellular K+ content B. Unabsorbed Na+ load presented to the distal segment C. Aldosterone level D. All of the above

Description : Secretion of K+ in the late distal tubule and collecting ducts of kidney depends on: A. Intracellular K+ content B. Unabsorbed Na+ load presented to the distal segment C. Aldosterone level D. All of the above

Last Answer : D. All of the above

The Na+-Cl– symport in the early distal convoluted tubule of the kidney is inhibited by: A. Thiazides B. Metolazone C. Xipamide D. All of the above

Description : The Na+-Cl– symport in the early distal convoluted tubule of the kidney is inhibited by: A. Thiazides B. Metolazone C. Xipamide D. All of the above

Last Answer : D. All of the above

Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop of Henle. C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

Description : Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop ... C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions

Which of the following has a ‘self limiting diuretic’ (action of the drug itself causing changes which limit further diuresis) action: A. Indapamide B. Spironolactone C. Xipamide D. Acetazolamide

Description : Which of the following has a ‘self limiting diuretic’ (action of the drug itself causing changes which limit further diuresis) action: A. Indapamide B. Spironolactone C. Xipamide D. Acetazolamide

Last Answer : D. Acetazolamide

Antidiuretic hormone (A) Is secreted by hypothalamus (B) Secretion is increased when osmolality of plasma decreases (C) Increases obligatory reabsorption of water (D) Acts on distal convoluted tubules and collecting ducts

Description : Antidiuretic hormone (A) Is secreted by hypothalamus (B) Secretion is increased when osmolality of plasma decreases (C) Increases obligatory reabsorption of water (D) Acts on distal convoluted tubules and collecting ducts

Last Answer : Answer : D

Select the diuretic which is similar in efficacy and pattern of electrolyte excretion to furosemide, but is 40 times more potent dose to dose: A. Piretanide B. Bumetanide C. Xipamide D. Metolazone

Description : Select the diuretic which is similar in efficacy and pattern of electrolyte excretion to furosemide, but is 40 times more potent dose to dose: A. Piretanide B. Bumetanide C. Xipamide D. Metolazone

Last Answer : B. Bumetanide

A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished and ascitis again appeared. Select the measure to reinduce diuresis: A. Increase hydrochlorothiazide dose to 100 mg twice daily B. Add acetazolamide 250 mg twice daily C. Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Description : A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished ... Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Last Answer : C. Add spironolactone 50 mg thrice daily

Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above

Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above

Last Answer : Ans: A

In a normal nephron: a. the descending loop of Henle is impermeable to water b. anti-diuretic hormone (ADH) increases the permeability of collecting ducts to water c. all the filtered glucose is re-absorbed in the proximal tubule d. nearly all the filtered protein is reabsorbed in the proximal convoluted tubule

Description : In a normal nephron: a. the descending loop of Henle is impermeable to water b. anti-diuretic hormone (ADH) increases the permeability of collecting ducts to water c. all the filtered ... in the proximal tubule d. nearly all the filtered protein is reabsorbed in the proximal convoluted tubule

Last Answer : nearly all the filtered protein is reabsorbed in the proximal convoluted tubule

Furosemide inhibits reabsorption of sodium and chloride in (A) Proximal convoluted tubules (B) Loop of Henle (C) Distal convoluted tubules (D) Collecting ducts

Description : Furosemide inhibits reabsorption of sodium and chloride in (A) Proximal convoluted tubules (B) Loop of Henle (C) Distal convoluted tubules (D) Collecting ducts

Last Answer : Answer : B

Reabsorption of useful substances from glomerular filtrate occurs in (a) collecting tube (b) loop of Henle (c) proximal convoluted tubule (d) distal convoluted tubule.

Description : Reabsorption of useful substances from glomerular filtrate occurs in (a) collecting tube (b) loop of Henle (c) proximal convoluted tubule (d) distal convoluted tubule.

Last Answer : (c) proximal convoluted tubule

Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

Description : Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl- cotransport in the ascending limb of loop of Henle C ... in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

The primary site of action of thiazide diuretics is: A. Proximal tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts

Description : The primary site of action of thiazide diuretics is: A. Proximal tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts

Last Answer : C. Cortical diluting segment

Following potassium sparing diuretic is a mineralocorticoid receptor antagonist (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above

Description : Following potassium sparing diuretic is a mineralocorticoid receptor antagonist (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above

Last Answer : Ans: C

Following potassium sparing diuretic inhibits action of aldosterone (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above

Description : Following potassium sparing diuretic inhibits action of aldosterone (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above

Last Answer : Ans: C

Actions of oxytocin include the following except: A. Vasoconstriction B. Increased water reabsorption in renal collecting ducts C. Contraction of mammary myoepithelium D. Release of prostaglandins from endometrium

Description : Actions of oxytocin include the following except: A. Vasoconstriction B. Increased water reabsorption in renal collecting ducts C. Contraction of mammary myoepithelium D. Release of prostaglandins from endometrium

Last Answer : A. Vasoconstriction

The Na+ retaining action of aldosterone is exerted on the: A. Proximal convoluted tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Distal convoluted tubul

Description : The Na+ retaining action of aldosterone is exerted on the: A. Proximal convoluted tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Distal convoluted tubul

Last Answer : D. Distal convoluted tubule

Choose the correct statement about osmotic diuretics: A. They are large molecular weight substances which form colloidal solution B. Their primary site of action is collecting ducts in the kidney C. They increase water excretion without increasing salt excretion D. They can lower intraocular pressure

Description : Choose the correct statement about osmotic diuretics: A. They are large molecular weight substances which form colloidal solution B. Their primary site of action is collecting ducts in the ... C. They increase water excretion without increasing salt excretion D. They can lower intraocular pressure

Last Answer : D. They can lower intraocular pressure

Which one of the following correctly explains the function of a specific part of the human nephron? (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the Bowman’s capsule (b) Henle’s loop : most reabsorption of the major substances from the glomerular filtrate (c) Distal convoluted tubule : reabsorption of K+ ions into the surrounding blood capillaries (d) Afferent arteriole : carries the blood away from the glomerulus towards renal vein.

Description : Which one of the following correctly explains the function of a specific part of the human nephron? (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the ... blood capillaries (d) Afferent arteriole : carries the blood away from the glomerulus towards renal vein.

Last Answer : (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the Bowman’s capsule

Which of the following is a potassium retaining diuretic: A. Triamterene B. Trimethoprim C. Tizanidine D. Trimetazidine

Description : Which of the following is a potassium retaining diuretic: A. Triamterene B. Trimethoprim C. Tizanidine D. Trimetazidine

Last Answer : A. Triamterene

Anti-diuretic diuretic hormone (ADH) a. is synthesized by the posterior lobe of the pituitary gland b. is released by neurosecretion c. its secretion is increased by a low plasma osmolarity d. increases the permeability of the distal convoluted tubule

Description : Anti-diuretic diuretic hormone (ADH) a. is synthesized by the posterior lobe of the pituitary gland b. is released by neurosecretion c. its secretion is increased by a low plasma osmolarity d. increases the permeability of the distal convoluted tubule

Last Answer : is released by neurosecretion

Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule

Description : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule

Last Answer : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule ... levels D. Decrease in antidiuretic hormone levels

Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule? (a) Increase in aldosterone levels (b) Increase in antidiuretic hormone levels (c) Decrease in aldosterone levels (d) Decrease in antidiuretic hormone levels

Description : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule? (a) Increase in aldosterone levels (b) Increase in antidiuretic hormone levels (c) Decrease in aldosterone levels (d) Decrease in antidiuretic hormone levels

Last Answer : (a) Increase in aldosterone levels

The part of nephron involved in active reabsorption of sodium is (a) distal convoluted tubule (b) proximal convoluted tubule (c) Bowman’s capsule (d) descending limb of Henle’s loop.

Description : The part of nephron involved in active reabsorption of sodium is (a) distal convoluted tubule (b) proximal convoluted tubule (c) Bowman’s capsule (d) descending limb of Henle’s loop.

Last Answer : (b) proximal convoluted tubule

Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide

Description : Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide

Last Answer : B. Spironolactone

The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide

Description : The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide

Last Answer : C. Spironolactone

The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone

Description : The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone

Last Answer : B. Furosemide

The final concentration of the fluid to produce a markedly hypertonic urine takes place in (a) Loop of Henle (b) Distal convoluted tubule (c) Collecting tubule (d) Both (b) and (c)

Description : The final concentration of the fluid to produce a markedly hypertonic urine takes place in (a) Loop of Henle (b) Distal convoluted tubule (c) Collecting tubule (d) Both (b) and (c)

Last Answer : Ans:(c)

Which one of the four parts mentioned below does not constitute a part of single uriniferous tubule? (a) Distal convoluted tubule (b) Collecting duct (c) Bowman’s capsule (d) Loop of Henle

Description : Which one of the four parts mentioned below does not constitute a part of single uriniferous tubule? (a) Distal convoluted tubule (b) Collecting duct (c) Bowman’s capsule (d) Loop of Henle

Last Answer : (b) Collecting duct

Which one of the following statements in regard to the excretion by the human kidneys is correct? (a) Descending limb of loop of Henle is impermeable to water.(b) Distal convoluted tubule is incapable of reabsorbing HCO3 – . (c) Nearly 99 per cent of the glomerular filtrate is reabsorbed by the renal tubules. (d) Ascending limb of loop of Henle is impermeable to electrolytes.

Description : Which one of the following statements in regard to the excretion by the human kidneys is correct? (a) Descending limb of loop of Henle is impermeable to water. (b) Distal convoluted tubule is ... reabsorbed by the renal tubules. (d) Ascending limb of loop of Henle is impermeable to electrolytes.

Last Answer : (c) Nearly 99 per cent of the glomerular filtrate is reabsorbed by the renal tubules.

Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules

Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules

Last Answer : Answer : D

Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct

Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct

Last Answer : D. Both 'A' and 'B' are correct

Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis

Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis

Last Answer : C. Inducing the synthesis of Na+ K+ ATPase

The following tissue is most sensitive to vasopressin: A. Renal collecting ducts B. Intestinal smooth muscle C. Vascular smooth muscle D. Uterus

Description : The following tissue is most sensitive to vasopressin: A. Renal collecting ducts B. Intestinal smooth muscle C. Vascular smooth muscle D. Uterus

Last Answer : A. Renal collecting ducts

Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts

Description : Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts

Last Answer : B. Increased peristalsis of gut

Select the tissue that is most sensitive to oxytocin: A. Myometrium B. Myoepithelium of mammary alveoli C. Vascular smooth muscle D. Renal collecting ducts

Description : Select the tissue that is most sensitive to oxytocin: A. Myometrium B. Myoepithelium of mammary alveoli C. Vascular smooth muscle D. Renal collecting ducts

Last Answer : B. Myoepithelium of mammary alveoli

Assertion `:-` Angiotensin II is a powerful vasconstrictor Reason `:-` Aldosterone causes reabsorption of `Na^(+)` and water from distal parts of the

Description : Assertion `:-` Angiotensin II is a powerful vasconstrictor Reason `:-` Aldosterone causes reabsorption of `Na^(+)` and water from distal parts of the

Last Answer : Assertion `:-` Angiotensin II is a powerful vasconstrictor Reason `:-` Aldosterone causes reabsorption of ... D. If both Assertion & Reason are false.

Amiloride has the following effect on urinary cation excretion: A. Decreases both K+ and H+ ion excretion B. Decreases K+ excretion but increases H+ ion excretion C. Increases K+ but decreases Na+ excretion D. Decreases both Na+ and K+ excretion

Description : Amiloride has the following effect on urinary cation excretion: A. Decreases both K+ and H+ ion excretion B. Decreases K+ excretion but increases H+ ion excretion C. Increases K+ but decreases Na+ excretion D. Decreases both Na+ and K+ excretion

Last Answer : A. Decreases both K+ and H+ ion excretion

Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate

Description : Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate

Last Answer : B. Calcium

Furosemide acts by inhibiting the following in the renal tubular cell: A. Na+-K+-2Cl– cotransporter B. Na+-Cl– symporter C. Na+-H+ antiporter D. Na+ K+ ATPase

Description : Furosemide acts by inhibiting the following in the renal tubular cell: A. Na+-K+-2Cl– cotransporter B. Na+-Cl– symporter C. Na+-H+ antiporter D. Na+ K+ ATPase

Last Answer : A. Na+-K+-2Cl– cotransporter

Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secretion B. Cyclic AMP enhances but cyclic GMP inhibits Cl– and HCO3 – secretion C. Cyclic AMP inhibits but cyclic GMP enhances Na+ and Cl– reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl– reabsorption

Description : Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 - secretion B. Cyclic AMP enhances but cyclic GMP ... Cl- reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl- reabsorption

Last Answer : A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secreti

Angiotensin III is equipotent to angiotensin II in: A. Releasing aldosterone from adrenal cortex B. Promoting Na+ and water reabsorption by direct intrarenal action C. Causing vasoconstriction D. Contracting intestinal smooth muscle

Description : Angiotensin III is equipotent to angiotensin II in: A. Releasing aldosterone from adrenal cortex B. Promoting Na+ and water reabsorption by direct intrarenal action C. Causing vasoconstriction D. Contracting intestinal smooth muscle

Last Answer : A. Releasing aldosterone from adrenal cortex

he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect C. It can inhibit insulin release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori

Description : he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to ... release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori

Last Answer : B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect

Sodium valproate has been shown to: A. Prolong neuronal Na+ channel inactivation B. Attenuate ‘T’ type Ca2+ current in neurones C. Inhibit degradation of GABA by GABA-transaminase D. All of the above

Description : Sodium valproate has been shown to: A. Prolong neuronal Na+ channel inactivation B. Attenuate ‘T’ type Ca2+ current in neurones C. Inhibit degradation of GABA by GABA-transaminase D. All of the above

Last Answer : D. All of the above

For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamethasone/dexamethasone because: A. They do not cause Na+ and water retention B. They are more potent C. They can be administered intravenously D. They inhibit brain tumours

Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamethasone/dexamethasone because: A. They do not cause Na+ and water retention B. They are more potent C. They can be administered intravenously D. They inhibit brain tumours

Last Answer : A. They do not cause Na+ and water retention

The oral absorption of following osmotic diuretic is negligible (a) Glycerin (b) Mannitol (c) Isosorbide (d) All of the above

Description : The oral absorption of following osmotic diuretic is negligible (a) Glycerin (b) Mannitol (c) Isosorbide (d) All of the above

Last Answer : Ans: B

Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide

Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide

Last Answer : Answer : B