Description : Of the following diuretic medications, which conserves potassium? a) Spironolactone (Aldactone) Aldactone is known as a potassium-sparing diuretic. b) Furosemide (Lasix) Lasix causes loss of ... (Diuril) Diuril causes mild hypokalemia. d) Chlorthalidone (Hygroton) Hygroton causes mild hypokalemia.
Last Answer : a) Spironolactone (Aldactone) Aldactone is known as a potassium-sparing diuretic.
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Last Answer : Ans: A
Description : Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide
Last Answer : B. Spironolactone
Description : A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished ... Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly
Last Answer : C. Add spironolactone 50 mg thrice daily
Description : The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide
Last Answer : C. Spironolactone
Description : Which of the following has a ‘self limiting diuretic’ (action of the drug itself causing changes which limit further diuresis) action: A. Indapamide B. Spironolactone C. Xipamide D. Acetazolamide
Last Answer : D. Acetazolamide
Description : The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone
Last Answer : B. Furosemide
Description : Spironolactone is an antagonist of (A) Cortisol (B) Hydrocortisone (C) Aldosterone (D) Testosterone
Last Answer : Answer : C
Description : Following potassium sparing diuretic is a mineralocorticoid receptor antagonist (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above
Last Answer : Ans: C
Description : Following potassium sparing diuretic inhibits action of aldosterone (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above
Description : All the following diuretics inhibit the carbonic anhydrase except (A) Acetazolamide (B) Bumetanide (C) Furosemide (D) Ethacrynic acid
Last Answer : Answer : D
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : Which of the following diuretics would be most useful in a patient with cerebral edema? (a) Acetazolamide (b) Amiloride (c) Ethacrynic acid (d) Furosemide (e) Mannitol
Last Answer : Ans: E
Description : Following loop diuretic is a phynoxy acetic acid derivative (a) Furosemide (b) Bumetanide (c) Ethacrynic acid (d) All of the above
Description : The following diuretic reduces positive free water clearance but does not affect negative free water clearance: A. Hydroflumethiazide B. Furosemide C. Ethacrynic acid D. Mannitol
Last Answer : A. Hydroflumethiazide
Description : Though ethacrynic acid is also a high ceiling diuretic, it is practically not used because: A. It is more ototoxic B. It causes diarrhoea and gut bleeding C. Its response increases steeply over a narrow dose range D. All of the above
Last Answer : D. All of the above
Description : At equinatriuretic doses which diuretic causes the maximum K+ loss: A. Furosemide B. Hydrochlorothiazide C. Acetazolamide D. Amiloride
Last Answer : C. Acetazolamide
Description : The most appropriate measure to overcome diminished responsiveness to furosemide after its longterm use is: A. Switching over to parenteral administration of furosemide B. Addition of a thiazide diuretic C. Addition of acetazolamide D. Potassium supplementation
Last Answer : B. Addition of a thiazide diuretic
Description : The following diuretic acts on the luminal membrane of distal tubule and collecting ducts to inhibit electrogenic Na+ reabsorption so that K+ excretion is diminished and bicarbonate excretion is enhanced: A. Xipamide B. Isosorbide C. Triamterene D. Spironolactone
Last Answer : C. Triamterene
Description : Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop ... C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion
Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions
Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide
Last Answer : Answer : B
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Description : Calcitomica is antagonist to (A) Serotonin (B) Thyroxine (C) Tri iodo thyronine (D) Para thyroid hormone
Description : Dicoumarol is antagonist to (A) Riboflavin (B) Retinol (C) Menadione (D) Tocopherol
Description : Hypernatremia may occur in (A) Diabetes insipidus (B) Diuretic medication (C) Heavy sweating (D) Kidney disease
Last Answer : Answer : A
Description : A 75 year old man presents with a long history of shortness of breath and ankle oedema. His serum biochemistry shows sodium 122 mmols/l and potassium of 2.9 mmols/l. He now complains of ... ? 1) Addison's Disease 2) Nephrotic syndrome 3) Primary hyperaldosteronism 4) SIADH 5) Diuretic therapy
Last Answer : Answers-5 The long history of his symptoms and serum biochemistry suggests that his condition is due to treatment with frusemide for CCF.
Description : he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma
Last Answer : D. Glaucoma
Description : The following is a competitive type of enzyme inhibitor: A. Acetazolamide B. Disulfiram C. Physostigmine D. Theophylline
Last Answer : C. Physostigmine
Description : Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine ... antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.
Last Answer : a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells.
Description : Which of the following therapies would be most useful in the management of severe hypercalcemia? (a) Amiloride plus saline infusion (b) Furosemide plus saline infusion (c) Hydrochlorothiazide plus saline infusion (d) Mannitol plus saline infusion (e) Spironolactone plus saline infusion
Last Answer : Ans: B
Description : Spironolactone can be usefully combined with the following diuretics except: A. Furosemide B. Amiloride C. Hydrochlorothiazide D. Chlorthalidone
Last Answer : B. Amiloride
Description : The following apply to use of spironolactone in CHF except: A. It is indicated only in NYHA class III/IV cases as additional drug to conventional therapy B. It affords prognostic benefit in ... by ACE inhibitors C. It helps overcome refractoriness to diuretics D. It affords rapid symptomatic relief
Last Answer : D. It affords rapid symptomatic relief
Description : The following drug is used for short-term control of emergency heart failure, but not for long-term treatment of congestive heart failure: A. Digoxin B. Ramipril C. Dobutamine D. Spironolactone
Last Answer : C. Dobutamine
Description : The following drug can relieve symptoms of CHF but does not retard disease progression or prolong survival: A. Digoxin B. Carvedilol C. Spironolactone D. Ramipril
Last Answer : A. Digoxin
Description : Select the drug that can help restore cardiac performance as well as prolong survival in CHF patients: A. Spironolactone B. Furosemide C. Dobutamine D. Metoprolol
Last Answer : D. Metoprolol
Description : Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate
Last Answer : C. Codeine
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Description : Diabetes insipidus results from (A) Decreased insulin secretion (B) Decreased ADH secretion (C) Decreased aldosterone secretion (D) Unresponsiveness of osmoreceptors
Description : Potassium metabolism is regulated by the hormone: (A) Aldosterone (B) PTH (C) Somatostatin (D) Estrogen
Description : The metabolism of sodium is regulated by the hormone: (A) Insulin (B) Aldosterone (C) PTH (D) Somatostatin
Description : Increased reabsorption of water from the kidney is the major consequence of which of the following hormones? (A) Cortisol (B) Insulin (C) Vasopressin (D) Aldosterone
Description : Which of the following hormone is not under the control of ACTH? (A) Aldosterone (B) Cortisol (C) Corticosterone (D) Deoxycorticosterone
Description : The most potent hormone concerned with the retention of sodium in the body is (A) Cortisone (B) Aldosterone (C) Corticosterone (D) Cortisol
Description : All the following statements about transcortin are true except (A) It is synthesised in liver (B) It transports glucocorticoids (C) It transports aldosterone (D) It transports progesterone
Description : A common intermediate in the synthesis of cortisol and aldosterone is (A) Progesterone (B) Testosterone (C) Estradiol (D) None of these
Description : The major mineralcorticoid is (A) Hydrocortisone (B) Aldosterone (C) Aldactone A (D) Androstenedione
Description : The precursor of testosterone is (A) Aldosterone (B) Methyl testosterone (C) Estrone (D) Pregnenolone
Description : A hormone which cannot cross the blood brain barrier is (A) Epinephrine (B) Aldosterone (C) ACTH (D) TSH