Description : Which of the following diuretics would be most useful in a patient with cerebral edema? (a) Acetazolamide (b) Amiloride (c) Ethacrynic acid (d) Furosemide (e) Mannitol
Last Answer : Ans: E
Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide
Last Answer : Answer : B
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Last Answer : Answer : D
Description : Following loop diuretic is a phynoxy acetic acid derivative (a) Furosemide (b) Bumetanide (c) Ethacrynic acid (d) All of the above
Last Answer : Ans: C
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : A diuretic which is an aldosterone antagonist is (A) Spironolactone (B) Ethacrynic acid (C) Acetazolamide (D) Chlorothiazide
Last Answer : Answer : A
Description : All of the following are zinc-containing enzymes except (A) Acid Phosphatase (B) Alkaline Phosphatase (C) Carbonic anhydrase (D) RNA polymerase
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Last Answer : Ans: A
Description : All of the following are iron-containing enzymes except (A) Carbonic anhydrase (B) Catalase (C) Peroxidase (D) Cytochrome oxidase
Description : The following diuretic reduces positive free water clearance but does not affect negative free water clearance: A. Hydroflumethiazide B. Furosemide C. Ethacrynic acid D. Mannitol
Last Answer : A. Hydroflumethiazide
Description : Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide
Last Answer : Ans: B
Description : Select the diuretic which is similar in efficacy and pattern of electrolyte excretion to furosemide, but is 40 times more potent dose to dose: A. Piretanide B. Bumetanide C. Xipamide D. Metolazone
Last Answer : B. Bumetanide
Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures
Last Answer : D. It is not effective in generalized tonic-clonic seizures
Description : Spironolactone can be usefully combined with the following diuretics except: A. Furosemide B. Amiloride C. Hydrochlorothiazide D. Chlorthalidone
Last Answer : B. Amiloride
Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors
Last Answer : Answer : C
Description : Zn is present as prosthetic group in this enzyme: (A) Carbonic anhydrase (B) Carboxy peptidase (C) Lactate dehydrogenase (D) All of these
Description : Zinc is a constituent of the enzyme: (A) Succinate dehydrogenase (B) Carbonic anhydrase (C) Mitochondrial superoxide dismutase (D) Aldolase
Description : Carbonic anhydrase enzyme has maximum turn over number (36 million). Minimum turn over number for an enzyme: (A) DNA polymerase (B) Lysozyme (C) Penicillase (D) Lactase dehydrogenase
Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide
Description : Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate
Last Answer : B. Calcium
Description : The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide
Last Answer : C. Spironolactone
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Description : At equinatriuretic doses which diuretic causes the maximum K+ loss: A. Furosemide B. Hydrochlorothiazide C. Acetazolamide D. Amiloride
Last Answer : C. Acetazolamide
Description : The most appropriate measure to overcome diminished responsiveness to furosemide after its longterm use is: A. Switching over to parenteral administration of furosemide B. Addition of a thiazide diuretic C. Addition of acetazolamide D. Potassium supplementation
Last Answer : B. Addition of a thiazide diuretic
Description : The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone
Last Answer : B. Furosemide
Description : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is present in RBC. B- Minute quantities of
Last Answer : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is ... and D C. A,B,C and D D. Only A
Description : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide combine with water and is transported.
Last Answer : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide ... A is correct and statement B is wrong.
Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above
Description : With regard to the transport of carbon dioxide in blood: a. 25% of carbon dioxide is dissolved in blood b. carbonic anhydrase is found in plasma c. 50% of carbon dioxide is carried as bicarbonate d. deoxygenated haemoglobin facilitates the transport of carbon dioxide
Last Answer : deoxygenated haemoglobin facilitates the transport of carbon dioxide
Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary
Last Answer : damage to the posterior pituitary
Description : Carbonic anhydrase occurs in (a) lymphocytes (b) blood plasma (c) RBCs (d) leucocytes.
Last Answer : (c) RBCs
Description : The enzyme that catalyses carbon dioxide fixation in C4 plants is (a) RuBP carboxylase (b) PEP carboxylase (c) carbonic anhydrase (d) carboxydismutase.
Last Answer : (b) PEP carboxylase
Description : In which one of the following enzymes, is copper necessarily associated as an activator? (a) Carbonic anhydrase (b) Tryptophanase (c) Lactic dehydrogenase (d) Tyrosinase
Last Answer : (d) Tyrosinase
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Use of potassium sparing diuretics in patients receiving the following drug needs close monitoring: A. Furosemide B. Hydrochlorothiazide C. Captopril D. Verapami
Last Answer : C. Captopril
Description : Though ethacrynic acid is also a high ceiling diuretic, it is practically not used because: A. It is more ototoxic B. It causes diarrhoea and gut bleeding C. Its response increases steeply over a narrow dose range D. All of the above
Last Answer : D. All of the above
Description : As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost
Last Answer : A. High ceiling antihypertensive action
Description : The following apply to use of spironolactone in CHF except: A. It is indicated only in NYHA class III/IV cases as additional drug to conventional therapy B. It affords prognostic benefit in ... by ACE inhibitors C. It helps overcome refractoriness to diuretics D. It affords rapid symptomatic relief
Last Answer : D. It affords rapid symptomatic relief
Description : Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate
Last Answer : C. Codeine
Description : Quantitatively, the most significant buffer system in plasma is (A) Phosphate buffer system (B) Carbonic acid-bicarbonate buffer system (C) Lactic acid-lactate buffer system (D) Protein buffer system
Description : Chloride shift is (A) H ions leaving the RBC in exchange of Cl- (B) Cl– leaving the RBC in exchange of bicarbonate (C) Bicarbonate ion returns to plasma and exchanged with chloride which shifts into the cell (D) Carbonic acid to the plasma
Description : Important buffer system of extracellular fluid is (A) Bicarbonate/carbonic acid (B) Disodium hydrogen phosphate/sodium dihydrogen phosphate (C) Plasma proteins (D) Organic Phosphate
Description : At the pH of blood 7.4, the ratio between the carbonic acid and bicarbonate fractions is (A) 1 : 10 (B) 1 : 20 (C) 1 : 30 (D) 1 : 40
Description : Respiratory alkalosis is caused by (A) An increase in carbonic acid fraction (B) A decrease in bicarbonic fraction (C) A decrease in the carbonic acid fraction (D) An increase in bicarbonate fraction