Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide
Last Answer : Answer : B
Description : The second generation sulfonylurea hypoglycaemics differ from the first generation ones in that they: A. Are more potent B. Are longer acting C. Do not lower blood sugar in nondiabetic subjects D. Are less prone to cause hypoglycaemic reaction
Last Answer : A. Are more potent
Description : Which of the following is a prodrug of adrenaline used topically in glaucoma: A. Brimonidine B. Dipivefrine C. Phenylpropanolamine D. Dorzolamide
Last Answer : B. Dipivefrine
Description : Chlorpropamide is not a preferred sulfonylurea because: A. Hypoglycaemic reaction is more common with it B. Incidence of alcohol intolerance reaction is higher with it C. It can produce cholestatic jaundice D. All of the above
Last Answer : D. All of the above
Description : Select the sulfonamide drug which is active against Pseudomonas and is used by topical application for prophylaxis of infection in burn cases: A. Sulfadiazine B. Silver sulfadiazine C. Sulfadoxine D. Sulfamethoxazole
Last Answer : B. Silver sulfadiazine
Description : Indicate the sulfonamide whose sodium salt yields a nearly neutral solution which is suitable for topical use in the eye: A. Sulfadiazine B. Sulfacetamide C. Sulfadoxine D. Sulfamoxole
Last Answer : B. Sulfacetamide
Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase
Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures
Last Answer : D. It is not effective in generalized tonic-clonic seizures
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : To be used as a topically applied ocular beta blocker a drug should have the following properties except: A. Strong local anaesthetic activity B. High lipophilicity C. High ocular capture D. Low systemic activity
Last Answer : A. Strong local anaesthetic activity
Description : Indicate the sulfonamide whose sodium salt yields a nearly neutral solution which is suitable for topical use in the eye (a) Sulfadiazine (b) Sulfacetamide (c) Sulfamerazine (d) Sulfamethizole
Last Answer : Ans: B
Description : The distinctive feature of terbinafine is: A. It is highly effective in histoplasmosis B. It can be used topically as well as orally for dermatophytosis C. It inhibits Mucor and Aspergillus as well D. Applied intravaginally it cures both candida as well as trichomonas vaginitis
Last Answer : B. It can be used topically as well as orally for dermatophytosis
Description : What is the mode of action of sulfonamide herbicide a). Amino acid synthesis inhibitor b). Photosynthesis inhibitor c). Lipid inhibitor d). Pigment inhibitor
Last Answer : a). Amino acid synthesis inhibitor
Description : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is present in RBC. B- Minute quantities of
Last Answer : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is ... and D C. A,B,C and D D. Only A
Description : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide combine with water and is transported.
Last Answer : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide ... A is correct and statement B is wrong.
Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors
Last Answer : Answer : C
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Last Answer : Answer : D
Description : Zn is present as prosthetic group in this enzyme: (A) Carbonic anhydrase (B) Carboxy peptidase (C) Lactate dehydrogenase (D) All of these
Description : Zinc is a constituent of the enzyme: (A) Succinate dehydrogenase (B) Carbonic anhydrase (C) Mitochondrial superoxide dismutase (D) Aldolase
Description : Carbonic anhydrase enzyme has maximum turn over number (36 million). Minimum turn over number for an enzyme: (A) DNA polymerase (B) Lysozyme (C) Penicillase (D) Lactase dehydrogenase
Description : All of the following are iron-containing enzymes except (A) Carbonic anhydrase (B) Catalase (C) Peroxidase (D) Cytochrome oxidase
Last Answer : Answer : A
Description : All of the following are zinc-containing enzymes except (A) Acid Phosphatase (B) Alkaline Phosphatase (C) Carbonic anhydrase (D) RNA polymerase
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Description : All the following diuretics inhibit the carbonic anhydrase except (A) Acetazolamide (B) Bumetanide (C) Furosemide (D) Ethacrynic acid
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above
Last Answer : Ans: A
Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide
Description : With regard to the transport of carbon dioxide in blood: a. 25% of carbon dioxide is dissolved in blood b. carbonic anhydrase is found in plasma c. 50% of carbon dioxide is carried as bicarbonate d. deoxygenated haemoglobin facilitates the transport of carbon dioxide
Last Answer : deoxygenated haemoglobin facilitates the transport of carbon dioxide
Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary
Last Answer : damage to the posterior pituitary
Description : Carbonic anhydrase occurs in (a) lymphocytes (b) blood plasma (c) RBCs (d) leucocytes.
Last Answer : (c) RBCs
Description : The enzyme that catalyses carbon dioxide fixation in C4 plants is (a) RuBP carboxylase (b) PEP carboxylase (c) carbonic anhydrase (d) carboxydismutase.
Last Answer : (b) PEP carboxylase
Description : In which one of the following enzymes, is copper necessarily associated as an activator? (a) Carbonic anhydrase (b) Tryptophanase (c) Lactic dehydrogenase (d) Tyrosinase
Last Answer : (d) Tyrosinase
Description : After treating intestinal amoebiasis with metronidazole, a course of diloxanide furoate is often advised to: A. Cure any subclinical hepatic involvement B. Suppress the symbiotic intestinal flora C. Eradicate luminal cyst forming trophozoites D. Both ‘B’ and ‘C’ are correc
Last Answer : C. Eradicate luminal cyst forming trophozoites
Description : The following diuretic acts on the luminal membrane of distal tubule and collecting ducts to inhibit electrogenic Na+ reabsorption so that K+ excretion is diminished and bicarbonate excretion is enhanced: A. Xipamide B. Isosorbide C. Triamterene D. Spironolactone
Last Answer : C. Triamterene
Description : Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Aldosterone increases Na+ reabsorption and K+ excretion in the renal collecting duct cells by: A. Inducing synthesis of Na+K+ATPase B. Inducing synthesis of amiloride sensitive Na+ channels C. Translocating Na+ channels from cytosolic site to luminal membrane D. All of the above
Description : The thiazolidinediones are mainly used as: A. Sole drug in type 1 diabetes mellitus B. Sole drug in type 2 diabetes mellitus C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus D. Addon drug to insulin in type 1 ... 18.34 1 8 . 3 4 B 18.35 1 8 . 3 5 D 18.36 1 8 . 3 6 C
Last Answer : C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus
Description : Which of the following is not a sulfonylurea but acts by analogous mechanism to bring about quick and brief insulin release that is useful for normalizing meal time glycaemic excursions in type 2 diabetes mellitus: A. Glimepiride B. Miglitol C. Repaglinide D. Rosiglitazone
Last Answer : C. Repaglinide
Description : Which of the following drugs can precipitate hypoglycaemia if given to a diabetic controlled with a sulfonylurea drug: A. Phenobarbitone B. Chloramphenicol C. Rifampicin D. Oral contraceptive
Last Answer : . Chloramphenicol
Description : Sulfonylurea hypoglycaemics act by: A. Reducing intestinal absorption of glucose B. Increasing insulin secretion from pancreas C. Reversing down-regulation of insulin receptors D. Both ‘B’ and ‘C’ are correct
Description : Which of the following is not a specific indication for the more expensive monocomponent/human insulins: A. Insulin resistance B. Pregnant diabetic C. Sulfonylurea maintained diabetic posted for surgery D. Type 1 diabetes mellitus
Last Answer : D. Type 1 diabetes mellitus
Description : Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers ... 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes
Last Answer : B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus
Description : The hypoglycaemic action of sulfonylureas is likely to be attenuated by the concurrent use of: A. Hydrochlorothiazide B. Propranolol C. Theophylline D. Aspirin
Last Answer : A. Hydrochlorothiazide
Description : The monocomponent insulin preparations differ from the conventional preparations in the following respects except: A. They are less allergenic B. They cause less hypoglycaemic reactions C. They cause less lipodystrophy D. They are less liable to induce insulin resistance
Last Answer : B. They cause less hypoglycaemic reactions
Description : he monocomponent insulin preparations differ from the conventional preparations in the following respects except: A. They are less allergenic B. They cause less hypoglycaemic reactions C. They cause less lipodystrophy D. They are less liable to induce insulin resistance