Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor

Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
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Answer :

A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
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Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis

Description : Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis

Last Answer : B. All lack dependence producing liability

The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen

Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen

Last Answer : B. Meloxicam

Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Description :  Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Last Answer : D. Do not inhibit platelet aggregation

Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine

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Sulbactam differs from clavulanic acid in that: A. It is not a progressive inhibitor of β-lactamase B. It does not inhibit β-lactamase produced by gram negative bacilli C. It is quantitatively more potent D. It per se inhibits N.gonorrhoeae

Description : Sulbactam differs from clavulanic acid in that: A. It is not a progressive inhibitor of β-lactamase B. It does not inhibit β-lactamase produced by gram negative bacilli C. It is quantitatively more potent D. It per se inhibits N.gonorrhoeae

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For a patient of peptic ulcer, the safest nonopioid analgesic is: A. Celecoxib B. Diclofenac sodium C. Paracetamol D. Ibuprofen

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Last Answer : C. Paracetamol

The distinctive feature of nimesulide is: A. It does not inhibit prostaglandin synthesis B. It does not cause gastric irritation C. It is usually well tolerated by aspirin intolerant asthma patients D. It is not bound to plasma proteins

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Choose the action for which the dose of aspirin required is the lowest: A. Analgesic B. Antipyretic C. Antiinflammatory D. Antiplatelet aggregatory

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Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

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Last Answer : D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Choose the orally active third generation cephalosporin having good activity against gram positive cocci as well: A. Cefdinir B. Ceftazidime C. Cefoperazone D. Ceftizoxime

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Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects

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Last Answer : D. It is unlikely to produce anti-androgenic side effects

Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

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Last Answer : C. It is used orally to treat genital herpes simplex

Choose the correct statement(s) about auranofin: A. It is an orally active gold compound B. It is equally effective but less toxic than injected gold-sodium-thiomalate C. Its major adverse effect is dermatitis D. All of the above are correct

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Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct

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Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III hyperlipoproteinemia C. It is not effective in diabetes associated hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

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Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Choose the most potent and most efficacious LDLcholesterol lowering HMG-CoA reductase inhibitor: A. Lovastatin B. Simvastatin C. Pravastatin D. Atorvastatin

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Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop of Henle. C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

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Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor

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Choose the selective serotonin reuptake inhibitor that is less likely to inhibit CYP2D6 and CYP3A4 resulting in fewer drug interactions: A. Sertraline B. Paroxetine C. Fluoxetine D. Fluvoxamine

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Which analgesic-antiinflammatory drug is more appropriate in musculo-skeletal disorder where pain is more prominent than inflammation: A. Ibuprofen B. Piroxicam C. Indomethacin D. Nimesulide

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An opioid analgesic is preferred over aspirin like analgesic in the following condition: A. Acute gout B. Burn C. Toothache D. Neuralgi

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Select the analgesic which acts through opioid as well as additional spinal monoaminergic mechanisms: A. Tramadol B. Ethoheptazine C. Dextropropoxyphene D. Alfentanil

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Apraclonidine is a clonidine congener which is used: A. To suppress opioid withdrawal syndrome B. To suppress menopausal syndrome C. As Analgesic D. To reduce intraocular tension

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Apraclonidine is a clonidine congener which is used: A. To suppress opioid withdrawal syndrome B. To suppress menopausal syndrome C. As Analgesic D. To reduce intraocular tension

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Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself, but its metabolite alloxanthine is a competitive inhibitor of xanthine oxidase D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase

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Last Answer : B. It is a competitive inhibitor of xanthine oxidase

The following opioid is more potent than morphine: A. Pethidine B. Fentanyl C. Dextropropoxyphene D. Tramadol

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Last Answer : B. They inhibit intestinal peristalsis

The following is true of linezolid except: A. It inhibits bacterial protein synthesis at an early step B. It is active against vancomycin resistant enterococci C. It is the drug of choice for enterococcal endocarditis D. It can be administered orally as well as by i.v. infusion

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Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin

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Last Answer : A. Nimesulide

he following is true of desmopressin except: A. It is nonselective V1 and V2 receptor agonist B. It is more potent and longer acting than arginine vasopressin (AVP) C. It is preferred over AVP for treatment of diabetes insipidus D. It can be administered orally

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Last Answer : A. It is nonselective V1 and V2 receptor agonist

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Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine

The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on virus directed reverse transcriptase which does not occur in noninfected cells D. Both ‘A’ and ‘B’ are correct

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Last Answer : D. Both ‘A’ and ‘B’ are correct

Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. Serum lithium levels are lowered by concurrent administration of NSAIDs D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding

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Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding

4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved C. They are used as adjuvants to antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea

Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea

Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved

For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamethasone/dexamethasone because: A. They do not cause Na+ and water retention B. They are more potent C. They can be administered intravenously D. They inhibit brain tumours

Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamethasone/dexamethasone because: A. They do not cause Na+ and water retention B. They are more potent C. They can be administered intravenously D. They inhibit brain tumours

Last Answer : A. They do not cause Na+ and water retention

Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above

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Last Answer : D. All of the above

In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b) Inhibit leukotriene synthesis (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above

Description : In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b ... (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above

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Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.

Description : Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs ... to cause immunosuppression. d) Antineoplastic agents Antineoplastic agents are known to cause immunosuppression.

Last Answer : a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.

Choose the correct statement about lactulose: A. It stimulates myenteric neurones to enhance gut peristalsis B. Administered orally it acts as a purgative within 2-4 hours C. It is an osmotic laxative that produces soft but formed stools D. All of the above are correct

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Last Answer : C. It is an osmotic laxative that produces soft but formed stools

Choose the correct statement about iron therapy: A. Haemoglobin response to intramuscular iron is faster than with oral iron therapy B. Iron must be given orally except in pernicious anaemia C. Prophylactic iron therapy must be given during pregnancy D. Infants on breastfeeding do not require medicinal iron

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Last Answer : C. Prophylactic iron therapy must be given during pregnancy

Choose the correct statement about bambuterol: A. It is an orally acting bronchodilator B. It is a prodrug C. It inhibits the enzyme pseudocholinesterase D. All of the above

Description : Choose the correct statement about bambuterol: A. It is an orally acting bronchodilator B. It is a prodrug C. It inhibits the enzyme pseudocholinesterase D. All of the above

Last Answer : D. All of the above

Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism

Description : Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism

Last Answer : C. In equianalgesic doses it is safer than aspirin