Description : Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Lucey-Driscoll syndrome (D) Rotor’s syndrome
Last Answer : Answer : D
Description : The active transport system for hepatic uptake of bilirubin is congenitally defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Rotor’s syndrome (D) Dubin-Johnson syndrome
Last Answer : Answer : A
Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome
Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
Description : Bile pigments are present and urobilinogen absent in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Crigler-Najjar syndrome
Last Answer : Answer : C
Description : Unconjugated bilirubin is derived principally from: C A. glucuronyl transferase activity B. toxic liver injury C. breakdown of senescent red blood cells D. None of these
Last Answer : breakdown of senescent red blood cells
Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria
Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.
Description : Bile pigments are absent and urobilinogen increased in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Glucuronyl transferase?
Last Answer : DefinitionGlucuronyl transferase is a liver enzyme. It changes bilirubin into a form that can be removed through the bile. It also changes some hormones, medicines, and toxins into non-harmful products.If the ... D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.
Description : Galactose 1-phosphate is converted to uridine diphosphate galactose, the reaction is catalysed by the enzyme: (A) Glactokinase (B) Galactose 1-phosphate uridyl transferase (C) Uridine diphospho galactose 4-epimerase (D) UDP glucose pyrophosphorylase
Last Answer : Answer : B
Description : In hemolytic jaundice, bilirubin in urine is (A) Usually absent (B) Usually present (C) Increased very much (D) Very low
Description : In obstructive jaundice, urinary bilirubin is (A) Absent (B) Increased (C) Present (D) Present in small amount
Description : In hemolytic jaundice, the urinary bilirubin is (A) Normal (B) Absent (C) More than normal (D) Small amount is present
Description : Bile pigments are not present in urine in (A) Haemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Serum albumin: globulin ratio is altered in (A) Gilbert’s disease (B) Haemolytic jaundice (C) Viral hepatitis (D) Stones in bile duct
Description : Ceruloplasmin is absent in (A) Cirrhosis of liver (B) Wilson’s disease (C) Menke’s disease (D) Copper deficiency
Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin
Description : Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome
Description : Defective enzyme in Hurler’s syndrome is (A) α-L-diuronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase
Description : Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : Removal of BSP dye by the liver involves conjugation with (A) Thiosulphate (B) Glutamine (C) Cystein component of glutathione (D) UDP glucuronate
Description : Which type of jaundice in adults is the result of increased destruction of red blood cells? a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot ... is the result of liver disease. d) Non-obstructive Non-obstructive jaundice occurs with hepatitis.
Last Answer : a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot excrete the bilirubin as quickly as it is formed.
Description : On average red blood cells live around 120 days. The spleen is the main organ where old red blood cells are destroyed. During the red blood cell destruction the heme groups turn into bilirubin and this substance is then captured by the liver and later excreted in the bowels as part of the bile.
Last Answer : What are the functions of the spleen?
Description : Orotic aciduria type II reflects the deficiency of the enzyme: (A) Orotate phosphoribosyl transferase (B) Orotidylate decarboxylase (C) Dihydroorotase (D) Dihydroorotate dehydrogenase
Description : Increased serum ornithine carabamoyl transferase activity is diagnostic of (A) Myocardial infarction (B) Hemolytic jaundice (C) Bone disease (D) Acute viral hepatitis
Description : An inborn error, maple syrup urine disease is due to deficiency of the enzyme: (A) Isovaleryl-CoAhydrogenase (B) Phenylalnine hydroxylase (C) Adenosyl transferase (D) α-Ketoacid decarboxylase
Description : Translocation of the newly formed peptidyl tRNA at the A site into the empty P site involves (A) EF-II, GTP (B) EF-I, GTP (C) EF-I, GDP (D) Peptidyl transferase, GTP
Description : Apolipoprotein C-II is an activator of (A) Lecithin cholesterola acyl transferase (B) Phospholipase C (C) Extrahepatic lipoprotein lipase (D) Hepatic lipoprotein lipase
Description : Who was Dr. Gilbert's personal physician ?
Last Answer : Gilbert was the last physician of Queen Elizabeth I of Britain .
Description : Who is Elena Gilbert's father?
Last Answer : In the T.V show her real parents are Jhonathan Gilbert Jeremy's uncle, Elena's biological father, and member of the Founder's Council; claims extensive knowledge of the town, vampires and ... own request.In the book series Elena is not adopted her biological parents are Grayson and Miranda Gilbert
Description : What is Elena Gilbert's occupation?
Last Answer : Elena Gilbert is a/an High school student (formerly)College student (formerly)Doctor (present)
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Description : The affected organ in Mc Ardle’s syndrome is (A) Liver (B) Kidney (C) Liver and Heart (D) Skeletal muscle
Description : Mc Ardle’s syndrome is characterized by the absence of (A) Liver phosphorylase (B) Muscle phosphorylase (C) Branching enzyme (D) Debranching enzyme
Description : In increase in α2-Globulin with loss of albumin in urine suggests (A) Primary immune deficiency (B) Nephrotic syndrome (C) Cirrhosis of liver (D) Multiple myeloma
Description : A decrease in albumin with increased production of other unidentified proteins which migrate in β, γ region suggests (A) Cirrhosis of liver (B) Nephrotic syndrome (C) Infection (D) Chronic lymphatic leukemia
Description : Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these
Last Answer : Unconjugated bilirubin
Description : Which one of the following tests would be most effective in ruling out the presence of active hepatocellular disease? A. Serum alanine aminotransferase (ALT) B. Serum total bilirubin C. cell surface markers D. None of these
Last Answer : Serum alanine aminotransferase (ALT)
Description : Plasma non-functional enzymes are (A) totally absent (B) low concentration in plastic (C) important for diagnosis of several disease (D) All of these
Description : Debranching enzyme is absent in (A) Cori’s disease (B) Andersen’s disease (C) Von Gierke’s disease (D) Her’s disease
Last Answer : A
Description : Glucose-6-phosphatase is absent or deficient in (A) Von Gierke’s disease (B) Pompe’s disease (C) Cori’s disease (D) McArdle’s disease
Description : The Fe containing pigments is (A) Haematoidin (B) Bilirubin (C) Hemasiderin (D) Urobilinogen
Description : Breakdown of 1gm haemoglobin produces (A) 20 mg of bilirubin (B) 35 mg of bilirubin (C) 50 mg of bilirubin (D) 70 mg of bilirubin
Description : Unconjugated bilirubin in serum is soluble in (A) Water (B) Alkalis (C) Acids (D) Methanal
Description : If results of the serum bilirubin, serum ALP, LDH and AST determinations suggest obstructive jaundice, the best confirmatory test would be the estimation of (A) Serum ALT (B) Serum 5’ nucleotidase (C) Serum Pseudo cholinesterase (D) None of these
Description : Biluveridin is converted to bilirubin by the process of (A) Oxidation (B) Reduction (C) Conjugation (D) Decarboxylation
Description : All the following statements about obstructive jaundice are true except (A) Conjugated bilirubin in serum is normal (B) Total bilirubin in serum is raised (C) Bile salts are present in urine (D) Serum alkaline phosphatase is raised
Description : The presence of bilirubin in the urine without urobilinogen suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Pernicious anemia (D) Damage to the hepatic parenchyma
Description : A mixture of conjugated and unconjugated bilirubin is found in the circulation in (A) Hemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Post hepatic jaundice
Description : Increased urobilinogen in urine and absence of bilirubin in the urine suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Viral hepatitis (D) Toxic jaundice