Description : Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Lucey-Driscoll syndrome (D) Rotor’s syndrome
Last Answer : Answer : D
Description : Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome
Last Answer : Answer : A
Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome
Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
Description : Bile pigments are present and urobilinogen absent in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Crigler-Najjar syndrome
Last Answer : Answer : C
Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria
Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.
Description : Dubin-Johnson syndrome?
Last Answer : DefinitionDubin-Johnson syndrome is a disorder passed down through families (inherited) in which a person has mild jaundice throughout life.Causes, incidence, and risk factorsDubin-Johnson syndrome is a very ... and the whites of the eyes to turn yellow (jaundiced). Severely high levels of biliru
Description : Bile pigments are not present in urine in (A) Haemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Which of the following is NOT characteristic of Down’s syndrome? A. Decreased neutrophil function B. Macroglossia C. Macrodontia D. An increased susceptibility to periodontal disease E. Congenitally missing teeth
Last Answer : C. Macrodontia
Description : The presence of bilirubin in the urine without urobilinogen suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Pernicious anemia (D) Damage to the hepatic parenchyma
Description : A mixture of conjugated and unconjugated bilirubin is found in the circulation in (A) Hemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Post hepatic jaundice
Last Answer : Answer : B
Description : Bile pigments are absent and urobilinogen increased in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Serum albumin: globulin ratio is altered in (A) Gilbert’s disease (B) Haemolytic jaundice (C) Viral hepatitis (D) Stones in bile duct
Description : The effects of glucocorticoid hormones include: a. increase hepatic glycogen synthesis b. decrease glucose uptake by the adipose tissue c. decrease hepatic gluconeogesis d. increase protein synthesis in the skeletal muscles
Last Answer : . increase hepatic glycogen synthesis
Description : Which one of the following tests would be most effective in ruling out the presence of active hepatocellular disease? A. Serum alanine aminotransferase (ALT) B. Serum total bilirubin C. cell surface markers D. None of these
Last Answer : Serum alanine aminotransferase (ALT)
Description : Defective enzyme in Hurler’s syndrome is (A) α-L-diuronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : In Hunter’s syndrome (A) There is progressive corneal opacity (B) Keratan sulphate is excreted in the urine (C) Enzyme defective is arylsulphatase B (D) Hearing loss is perceptive
Description : Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Description : Richner-Hanhart syndrome is due to defect in (A) Tyrosinase (B) Phenylalanine hydroxylase (C) Hepatic tyrosine transaminase (D) Fumarylacetoacetate hydrolase
Description : Serum LDL has been found to be increased in (A) Obstructive jaundice (B) Hepatic jaundice (C) Hemolytic jaundice (D) Malabsorption syndrome
Description : A 60-year-old man was diagnosed last year with adenocarcinoma of the lung, and a 4 cm mass lesion was treated with a right lower lobectomy. He now has an ... 2) Membranous glomerulonephritis 3) Minimal change glomerulonephritis 4) Nodular glomerulosclerosis 5) Rapidly progressive glomerulonephritis
Last Answer : Answers-2 Most cases of membranous GN are idiopathic, but in some patients there is a history of an infection or a malignancy (usually lung) with antigenemia.
Description : Insulin is required for the active uptake of glucose by most of the cells except (A) Muscle cells (B) Renal tubular cells (C) Adipocytes (D) Liver cells
Description : Thyroid gland takes up circulating iodine (A) By simple diffusion (B) By facilitated diffusion (C) By active uptake (D) In exchange for chloride
Description : Sodium is involved in the active uptake of (A) D-Glucose (B) D-Galactose (C) L-Amino acids (D) All of these
Description : Active uptake of glucose is inhibited by (A) Ouabain (B) Phlorrizin (C) Digoxin (D) Alloxan
Last Answer : B
Description : Haem synthetase is congenitally deficient in (A) Congenital erythropoietic porphyria (B) Protoporphyria (C) Hereditary coproporphyria (D) Variegate porphyria
Description : Down Syndrome, a congenital genetic disorder in human beings, is cased by : (a) a defective recessive gene in homozygous condition (b) an extra x chromosome (c) trisomy of chromosome 18 (d) trisomy of chromosome 21
Last Answer : Ans:(d)
Description : Which of the following statement(s) is/are true concerning metabolic derangements in sepsis and the systemic inflammatory response syndrome which may follow progressive shock? a. Alterations in glucose ... The serum aromatic amino acids fall rapidly as they are actively used in oxidative metabolism
Last Answer : Answer: b, c A broad spectrum of metabolic abnormalities become apparent in sepsis and the systemic inflammatory response syndrome following shock. Disruption of the normal cycles of carbohydrate, ... acetyl coenzyme A. This results in reduced serum level of leucine, isoleucine and valine
Description : Altering the amino acid profile in total parenteral nutrition solutions can be of benefit in certain conditions. Which of the following conditions are associated with a benefit by supplementation with the ... c. Short gut syndrome and glutamine d. Chronic renal failure and essential amino acids
Last Answer : Answer: a, c In a number of conditions, altering the amino acid profile of the total parenteral nutrition solution can be of benefit. TPN with amino acids of high biologic value ... Glutamine-enriched TPN partially attenuates villous atrophy and may be useful in treatment of short gut syndrome
Description : All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers
Description : α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease
Description : Which is the defective enzyme in von Gierkeís disease (glycogen storage disease type I)?
Last Answer : Glucose-6-phosphatase.
Description : The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on ... reverse transcriptase which does not occur in noninfected cells D. Both A' and B' are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : A 12 years-old girl complains of sore mouth, she has painful cervical lymphadenitis and a temperature of 39°c, oral examination shows numerous yellow grey lesions. What is the MOST LIKELY ... mentor hombres mas de 20 años en labios C. Herpetic gingivostomatitis D. Stevens-Johnson syndrome
Last Answer : C. Herpetic gingivostomatitis
Description : Bisphosphonates are indicated in the following condition: A. Organophosphate poisoning B. Dementia C. Steven’s Johnson syndrome D. Osteoporosis
Last Answer : D. Osteoporosis
Description : In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased
Description : Menke’s disease (Kinky or steel hair disease) is a X-linked disease characterized by (A) High levels of plasma copper (B) High levels of ceruloplasmin (C) Low levels of plasma copper and of ceuloplasmin (D) High level of hepatic copper
Description : _____ can spread from person to person in respiratory secretions or it may be inherited congenitally. a. Measles b. Chickenpox c. Rosella d. Herpes
Last Answer : c. Rosella
Description : Most congenitally missing teeth are: A. Mandibular 3rd molars B. Mandibular 2nd premolars C. Maxillary lateral incisor
Last Answer : A. Mandibular 3rd molars
Description : What are the commonest congenitally missing teeth:VERY CONTROVERSIAL BUT SEE THE SAMPLE QUESTIONS FROM ADC IT’S THE ANSWER A. 12, 22 B. 35, 45 ACC TO CAMERON C. 15, 25 D. 33, 43
Last Answer : A. 12, 22
Description : With regard to the blood retina barrier: a. the outer blood retina is formed by the retinal pigment epithelium cells and their junctions b. the blood retina barrier is typically defective in the ... fluid and anions from the extracellular space of the retina into the circulation d. all above
Last Answer : all above
Description : The expansion for AIDS is - (1) Active Immuno Deficiency Syndrome (2) Acquired Individual Disease Syndrome (3) Acquired Immuno Deficiency Syndrome (4) Acquired Immuno Disease Syndrome
Last Answer : (3) Acquired Immuno Deficiency Syndrome Explanation: Human immunodeficiency virus infection I acquired immunodeficiency syndrome (HIV/AIDS) is a disease of the human immune system caused by the human immunodeficiency ... slow the course of the disease and may lead to a near-normal life expectancy.
Description : The expansion for AIDS is (1) Active Immuno Deficiency Syndrome (2) Acquired Individual Disease Syndrome (3) Acquired Immuno Deficiency Syndrome (4) Acquired Immuno Disease Syndrome
Last Answer : Acquired Immuno Deficiency Syndrome
Description : Interleukin-6 is recognized as the cytokine primarily responsible for the alteration in hepatic protein synthesis recognized as the acute phase response. Which of the following statement(s) is/are true ... physiologic role of acute phase proteins are to reduce the systemic effects of tissue damage
Last Answer : Answer: c, d IL-6 is now recognized at the cytokine primarily responsible for the alteration in hepatic synthesis recognized as the acute phase response. Glucocorticoid hormones augment ... that generally inhibit the tissue destruction that is associated with the local initiation of inflammation
Description : Who was Dr. Gilbert's personal physician ?
Last Answer : Gilbert was the last physician of Queen Elizabeth I of Britain .
Description : Who is Elena Gilbert's father?
Last Answer : In the T.V show her real parents are Jhonathan Gilbert Jeremy's uncle, Elena's biological father, and member of the Founder's Council; claims extensive knowledge of the town, vampires and ... own request.In the book series Elena is not adopted her biological parents are Grayson and Miranda Gilbert
Description : What is Elena Gilbert's occupation?
Last Answer : Elena Gilbert is a/an High school student (formerly)College student (formerly)Doctor (present)
Description : Which of the following contributes to harmonics distortion in amplifiers? A) Positive feedback B) Presence of noise C) Defective active device D) Non linearity in active device.
Last Answer : D) Non linearity in active device.
Description : Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these
Last Answer : Unconjugated bilirubin