Description : The active transport system for hepatic uptake of bilirubin is congenitally defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Rotor’s syndrome (D) Dubin-Johnson syndrome
Last Answer : Answer : A
Description : Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome
Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria
Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.
Description : Bile pigments are present and urobilinogen absent in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Crigler-Najjar syndrome
Last Answer : Answer : C
Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin
Last Answer : Answer : B
Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome
Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
Description : Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these
Last Answer : Unconjugated bilirubin
Description : All the following statements about obstructive jaundice are true except (A) Conjugated bilirubin in serum is normal (B) Total bilirubin in serum is raised (C) Bile salts are present in urine (D) Serum alkaline phosphatase is raised
Description : A mixture of conjugated and unconjugated bilirubin is found in the circulation in (A) Hemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Post hepatic jaundice
Description : One of the causes of hemolytic jaundice is (A) G-6 phosphatase deficiency (B) Increased conjugated bilirubin (C) Glucokinase deficiency (D) Phosphoglucomutase deficiency
Description : The normal range of direct reacting (conjugated) serum bilirubin is (A) 0–0.1 mg/100 ml (B) 0.1–0.4 mg/100 ml (C) 0.4–06 mg/100 ml (D) 0.5–1 mg/100 ml
Description : Serum concentration is increased when destruction of erythrocytes is increased A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these
Description : Which of the following processes plays the major role in terminating the action of phenobarbitone: A. Biliary excretion B. Renal excretion C. Hepatic metabolism D. Redistribution
Last Answer : B. Renal excretion
Description : Pre- hepatic jaundice occurs because of (A) Increased haemolysis (B) Liver damage (C) Biliary obstruction (D) None of these
Description : Prothrombin time remains prolonged even after parenterals administration of vitamin K in (A) Haemolytic jaundice (B) Liver damage (C) Biliary obstruction (D) Steatorrhoea
Description : Bile pigments are not present in urine in (A) Haemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Bile pigments are absent and urobilinogen increased in urine in (A) Haemolytic jaundice (B) Hepatocellular jaundice (C) Obstructive jaundice (D) Rotor’s syndrome
Description : Serum albumin: globulin ratio is altered in (A) Gilbert’s disease (B) Haemolytic jaundice (C) Viral hepatitis (D) Stones in bile duct
Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above
Last Answer : D. All of the above
Description : On average red blood cells live around 120 days. The spleen is the main organ where old red blood cells are destroyed. During the red blood cell destruction the heme groups turn into bilirubin and this substance is then captured by the liver and later excreted in the bowels as part of the bile.
Last Answer : What are the functions of the spleen?
Description : Unconjugated bilirubin is derived principally from: C A. glucuronyl transferase activity B. toxic liver injury C. breakdown of senescent red blood cells D. None of these
Last Answer : breakdown of senescent red blood cells
Description : Which type of jaundice in adults is the result of increased destruction of red blood cells? a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot ... is the result of liver disease. d) Non-obstructive Non-obstructive jaundice occurs with hepatitis.
Last Answer : a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot excrete the bilirubin as quickly as it is formed.
Description : Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be ... xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease
Last Answer : Answers-4 In prolonged cholestasis features include: increased serum cholesterol, a moderate increase in triglyceride, the serum is not lipaemic, and reduced HDL levels. Clinical features include: ... persisted for more than 3 months sometimes fat deposits may involve bone and peripheral nerves.
Description : Defective enzyme in Hurler’s syndrome is (A) α-L-diuronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : In Hunter’s syndrome (A) There is progressive corneal opacity (B) Keratan sulphate is excreted in the urine (C) Enzyme defective is arylsulphatase B (D) Hearing loss is perceptive
Last Answer : Answer : D
Description : Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase
Description : Urinary excretion of vanillyl madelic acid is increased in (A) Phaeochromocytoma (B) Cushing’s syndrome (C) Carcinoid syndrome (D) Aldosteronism
Description : A 53-year-old man presented with hypertension of 150/110 mmHg. He is generally asymptomatic and has no previous medical history of note. He is a smoker of 5 cigarettes daily and drinks ... Adrenocortical adenoma 2) Bartter's syndrome 3) Liddle's syndrome 4) Liquorice ingestion 5) Pheochromocytoma
Last Answer : Answers-1 This patient is most likely to have Conn's syndrome as reflected by the hypokalaemic hypertension. Liquorice ingestion or Liddle's syndrome are again possible causes of ... hypertension (often diastolic hypertension), muscular weakness, paresthesias, headache, polyuria, and polydipsia."
Description : The normal route of calcium excretion is (A) Kidney (B) Kidney and Liver (C) Kidney and Intestine (D) Kidney, Intestine and Pancreas
Description : With regard to the lacrimal drainage system: a. the upper lacrimal punctum is lateral to the lower punctum b. the lacrimal canaliculi are lined by stratified squamous epithelium c. ... part of inferior meatus e. congenital blockage is due mainly to delay development of common canaliculus
Last Answer : the upper lacrimal punctum is lateral to the lower punctum
Description : Use of morphine in the following category of patients does not carry any special risk: A. Ischaemic heart disease patients B. Bronchial asthma patients C. Elderly male patients D. Biliary colic patients
Last Answer : A. Ischaemic heart disease patients
Description : Down Syndrome, a congenital genetic disorder in human beings, is cased by : (a) a defective recessive gene in homozygous condition (b) an extra x chromosome (c) trisomy of chromosome 18 (d) trisomy of chromosome 21
Last Answer : Ans:(d)
Description : Fecal urobilinogen is decreased in (A) Obstruction of biliary duct (B) Hemolytic jaundice (C) Excess fat intake (D) Low fat intake
Description : Fecal urobilinogen is increased in (A) Hemolytic jaundice (B) Obstruction of biliary duct (C) Extrahepatic gall stones (D) Enlarged lymphnodes
Description : Serum lipase is increased in (A) Acute parotitis (B) Acute pancreatitis (C) Infective hepatitis (D) Biliary obstruction
Description : All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers
Description : α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease
Description : Which is the defective enzyme in von Gierkeís disease (glycogen storage disease type I)?
Last Answer : Glucose-6-phosphatase.
Description : In biological studies which of the following is used to refer to the oxygen-binding, iron-containing, conjugated protein complex present in the sarcoplasm of muscle cells? a) myelin b) myosin c) myoglobin d) none of these
Last Answer : ANSWER: C -- MYOGLOBIN
Description : All following are conjugated proteins except (A) Nucleoproteins (B) Proteoses (C) Metalloproteins (D) Flavoproteins
Description : A conjugated protein present in the egg yolk is (A) Vitellin (B) Livetin (C) Albuminoids (D) Ovo-mucoid
Description : How are conjugated group subclassified?
Last Answer : Glycoproteins, lipoproteins, nucleoproteins, chro- moproteins, phospho-proteins and metallo-pro- teins.
Description : What are conjugated proteins?
Last Answer : Combinations of protein with a non-protein part is called prosthetic group.
Description : Which of the following statements are true of the multiple organ dysfunction syndrome (MODS)? A. The two-hit model proposes that secondary MODS may be produced when even a relatively ... intensive care units has decreased owing to increased awareness, prevention, and treatment of the syndrome.
Last Answer : Answer: ABC DISCUSSION: MODS is part of a clinical continuum that begins with the systemic inflammatory response syndrome, which is the host's stress response to any major insult such ... pathogenesis of MODS, the incidence of MODS continues to increase without a significant improvement in outcome
Description : In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased
Description : Pentosuria is a rare hereditary disease is characterized by increased urinary excretion of (A) L-xylulose (B) Xylitol (C) Xylulose 5-phosphate (D) Ribose 5-phosphate
Description : Who was Dr. Gilbert's personal physician ?
Last Answer : Gilbert was the last physician of Queen Elizabeth I of Britain .
Description : Who is Elena Gilbert's father?
Last Answer : In the T.V show her real parents are Jhonathan Gilbert Jeremy's uncle, Elena's biological father, and member of the Founder's Council; claims extensive knowledge of the town, vampires and ... own request.In the book series Elena is not adopted her biological parents are Grayson and Miranda Gilbert
Description : What is Elena Gilbert's occupation?
Last Answer : Elena Gilbert is a/an High school student (formerly)College student (formerly)Doctor (present)
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy