Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome

Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome
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Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase

Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase

Last Answer : Answer : A

All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be due to increased activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Last Answer : Answer : C

In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased

Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased

Last Answer : Answer : B

Salvage of purine bases is regulated by (A) Adenosine phosphoribosyl transferase (B) Hypoxanthine guanine phosphoribosyl transferase (C) Availability of PRPP (D) None of these

Description : Salvage of purine bases is regulated by (A) Adenosine phosphoribosyl transferase (B) Hypoxanthine guanine phosphoribosyl transferase (C) Availability of PRPP (D) None of these

Last Answer : Answer : C

The enzyme required for salvage of free purine bases is (A) Adenine phosphoribosyl transferase (B) Hypoxanthine guanine phosphoribosyl transferase (C) Both (A) and (B) (D) None of these

Description : The enzyme required for salvage of free purine bases is (A) Adenine phosphoribosyl transferase (B) Hypoxanthine guanine phosphoribosyl transferase (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Last Answer : Answer : B

All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males

Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males

Last Answer : Answer : C

All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Last Answer : Answer : A

Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy

Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy

Last Answer : Answer : A

Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above

Description : Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above

Last Answer : D. All of the above

All of the following can occur in LeschNyhan syndrome except (A) Gouty arthritis (B) Uric acid stones (C) Retarted growth (D) Self-mutiliating behaviour

Description : All of the following can occur in LeschNyhan syndrome except (A) Gouty arthritis (B) Uric acid stones (C) Retarted growth (D) Self-mutiliating behaviour

Last Answer : Answer : C

Inherited deficiency of purine nucleoside phosphorylase causes (A) Dwarfism (B) Mental retardation (C) Immunodeficiency (D) Gout

Description : Inherited deficiency of purine nucleoside phosphorylase causes (A) Dwarfism (B) Mental retardation (C) Immunodeficiency (D) Gout

Last Answer : Answer : C

Inherited deficiency of adenosine deaminase causes (A) Hyperuricaemia and gout (B) Mental retardation (C) Immunodeficiency (D) Dwarfism

Description : Inherited deficiency of adenosine deaminase causes (A) Hyperuricaemia and gout (B) Mental retardation (C) Immunodeficiency (D) Dwarfism

Last Answer : Answer : C

In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine

Description : In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine

Last Answer : Answer : D

The end product of purine catabolism in man is (A) Inosine (B) Hypoxanthine (C) Xanthine (D) Uric acid

Description : The end product of purine catabolism in man is (A) Inosine (B) Hypoxanthine (C) Xanthine (D) Uric acid

Last Answer : Answer : D

Hybridoma cells are selected by culturing them in a medium containing (A) Adenine, guanine, cytosine and thymine (B) Adenine, guanine, cytosine and uracil (C) Hypoxanthine, aminopterin and thymine (D) Hypoxanthine, aminopterin and thymidine

Description : Hybridoma cells are selected by culturing them in a medium containing (A) Adenine, guanine, cytosine and thymine (B) Adenine, guanine, cytosine and uracil (C) Hypoxanthine, aminopterin and thymine (D) Hypoxanthine, aminopterin and thymidine

Last Answer : Answer : D

Nitrosamine can deaminate (A) Cytosine to form uracil (B) Adenine to form xanthine (C) Guanine to form hypoxanthine (D) All of these

Description : Nitrosamine can deaminate (A) Cytosine to form uracil (B) Adenine to form xanthine (C) Guanine to form hypoxanthine (D) All of these

Last Answer : Answer : A

Free purine bases which can be salvaged are (A) Adenine and guanine (B) Adenine and hypoxanthine (C) Guanine and hypoxanthine (D) Adenine, guanine and hypoxanthine

Description : Free purine bases which can be salvaged are (A) Adenine and guanine (B) Adenine and hypoxanthine (C) Guanine and hypoxanthine (D) Adenine, guanine and hypoxanthine

Last Answer : Answer : D

An alternate substrate for orotate phosphoribosyl transferase is (A) Allopurinol (B) Xanthine (C) Hypoxanthine (D) Adenine

Description : An alternate substrate for orotate phosphoribosyl transferase is (A) Allopurinol (B) Xanthine (C) Hypoxanthine (D) Adenine

Last Answer : Answer : D

Trials for gene therapy in human beings were first carried out, with considerable success, in a genetic disease called (A) Cystic fibrosis (B) Thalassemia (C) Adenosine deaminase deficiency (D) Lesch-Nyhan syndrome

Description : Trials for gene therapy in human beings were first carried out, with considerable success, in a genetic disease called (A) Cystic fibrosis (B) Thalassemia (C) Adenosine deaminase deficiency (D) Lesch-Nyhan syndrome

Last Answer : Answer : C

Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Description : Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Last Answer : C. Uric acid

The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine

Description : The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine

Last Answer : Answer : A

High level of uric acid in the blood causes – (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Description : High level of uric acid in the blood causes – (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Last Answer : (2) Gout Explanation: High levels of uric acid in the blood can cause solid crystals to form within joints. This causes a painful condition called gout. If gout remains untreated, these uric acid crystals can build up in the joints and nearby tissues, forming hard lumpy deposits called tophi.

High level of uric acid in the blood causes (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Description : High level of uric acid in the blood causes (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Last Answer : Gout

What immunodeficiency disorder is associated with a tack of T and B cells and complete immune dysfunction? a. DiGeorge syndrome b. Severe combined immunodeficiency disease c. Chronic granulomatous disease d. Chédiak-Higashi syndrome

Description : What immunodeficiency disorder is associated with a tack of T and B cells and complete immune dysfunction? a. DiGeorge syndrome b. Severe combined immunodeficiency disease c. Chronic granulomatous disease d. Chédiak-Higashi syndrome

Last Answer : b. Severe combined immunodeficiency disease

Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine

Description : Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine

Last Answer : Answer : B

A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation

Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation

Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.

Conversion of inosine monophosphate to xanthine monophosphate is catalysed by (A) IMP dehydrogenase (B) Formyl transferase (C) Xanthine-guanine phosphoribosyl transferase (D) Adenine phosphoribosyl transferase

Description : Conversion of inosine monophosphate to xanthine monophosphate is catalysed by (A) IMP dehydrogenase (B) Formyl transferase (C) Xanthine-guanine phosphoribosyl transferase (D) Adenine phosphoribosyl transferase

Last Answer : Answer : A

All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate

Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate

Last Answer : Answer : A

Lesch-Nyhan syndrome?

Description : Lesch-Nyhan syndrome?

Last Answer : DefinitionLesch-Nyhan syndrome is an inheritable disorder that affects how the body builds and breaks down purines. Purines are a normal part of human tissue and help make up the body's genetic blueprint. ... to develop gout-like swelling in some of their joints. In some cases, kidney and bl

Purines: a. include guanine b. are metabolized to uric acid c. are mainly synthesized in the liver d. all above

Description : Purines: a. include guanine b. are metabolized to uric acid c. are mainly synthesized in the liver d. all above

Last Answer : all above

What is the best food to lower uric acid for those with gout?

Description : What is the best food to lower uric acid for those with gout?

Last Answer : The best thing you can do to help lower uric acid levels is to eat plenty of fruits and vegetables. Salads are great for your health and will also help to lower uric acid. Nuts are also good for lowering uric acid.

Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Glycosuria (i) Accumulation of uric acid in joints B. Gout (ii) Mass of crystallised salts within the kidney C. Renal calculi (iii) Inflammation in glomeruli D. Glomerular (iv) Presence of glucose in nephritis urine A B C D (a) (iii) (ii) (iv) (i) (b) (i) (ii) (iii) (iv) (c) (ii) (iii) (i) (iv) (d) (iv) (i) (ii) (iii)

Description : Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Glycosuria (i) Accumulation of uric acid in joints B. Gout (ii) Mass of crystallised salts within the kidney ... (iii) (iv) (c) (ii) (iii) (i) (iv) (d) (iv) (i) (ii) (iii)

Last Answer : (d) (iv) (i) (ii) (iii)

A 35-year-old male presented with an attack of acute gout. He was treated with a 10 day course of naproxen. His blood uric acid level is high. What future line of treatment is most appropriate: A. No regular medication. Treat attacks of acute gout when they occur with naproxen. B. Regular long-term treatment with naproxen C. Regular long-term treatment with allopurinol D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

Description : A 35-year-old male presented with an attack of acute gout. He was treated with a 10 day course of naproxen. His blood uric acid level is high. What future line of treatment is ... treatment with allopurinol D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

Last Answer : D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

In studies of the human body, which of the following terms is used to describe the hereditary condition associated with an excessively high level of uric acid in the blood? a) gout b) cystitis c) uric ptosis d) none of these

Description : In studies of the human body, which of the following terms is used to describe the hereditary condition associated with an excessively high level of uric acid in the blood? a) gout b) cystitis c) uric ptosis d) none of these

Last Answer : ANSWER: A -- GOUT 

Defective enzyme in Hurler’s syndrome is (A) α-L-diuronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase

Description : Defective enzyme in Hurler’s syndrome is (A) α-L-diuronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase

Last Answer : Answer : A

Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome

Description : Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome

Last Answer : Answer : A

Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase

Description : Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase

Last Answer : Answer : B

Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome

Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome

Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)

Absence of phenylalanine hydroxylase causes (A) Neonatal tyrosinemia (B) Phenylketonuria (C) Primary hyperoxaluria (D) Albinism

Description : Absence of phenylalanine hydroxylase causes (A) Neonatal tyrosinemia (B) Phenylketonuria (C) Primary hyperoxaluria (D) Albinism

Last Answer : Answer : D

Hunter’s syndrome results from absence of (A) Hexosaminidase A (B) Iduronate sulphatase (C) Neuraminidase (D) Arylsulphatase B

Description : Hunter’s syndrome results from absence of (A) Hexosaminidase A (B) Iduronate sulphatase (C) Neuraminidase (D) Arylsulphatase B

Last Answer : Answer : B

In adrenogenital syndrome due to total absence of 21-hydroxylase in adrenal cortex, there is (A) Deficient secretion of glucocorticoids (B) Deficient secretion of mineralcorticoids (C) Excessive secretion of androgens (D) All of these

Description : In adrenogenital syndrome due to total absence of 21-hydroxylase in adrenal cortex, there is (A) Deficient secretion of glucocorticoids (B) Deficient secretion of mineralcorticoids (C) Excessive secretion of androgens (D) All of these

Last Answer : Answer : D

Bassen-Kornzweig syndrome is due to (A) Absence of Apo-C-II (B) Defect in Apo-B synthesis (C) Absence of Apo-E (D) Absence of Apo-D

Description : Bassen-Kornzweig syndrome is due to (A) Absence of Apo-C-II (B) Defect in Apo-B synthesis (C) Absence of Apo-E (D) Absence of Apo-D

Last Answer : Answer : B

Zellweger’s syndrome is due to inherited absence of (A) Peroxisomes (B) Phospholipase A1 (C) Acyl-Co-A dehydrogenase (D) Thiolase

Description : Zellweger’s syndrome is due to inherited absence of (A) Peroxisomes (B) Phospholipase A1 (C) Acyl-Co-A dehydrogenase (D) Thiolase

Last Answer : Answer : A

Mc Ardle’s syndrome is characterized by the absence of (A) Liver phosphorylase (B) Muscle phosphorylase (C) Branching enzyme (D) Debranching enzyme

Description : Mc Ardle’s syndrome is characterized by the absence of (A) Liver phosphorylase (B) Muscle phosphorylase (C) Branching enzyme (D) Debranching enzyme

Last Answer : Answer : B

Phenytoin: 1) is a benzalkonium Derivative 2) is clinically effective serum level is in the range on 2-10 micrograms/ml. 3) A steady state blood level is achieved by 2-5 days 4) Can be used in management of alchohol withdrawl syndrome 5) Is the drug of choice in absence seizures.

Description : Phenytoin: 1) is a benzalkonium Derivative 2) is clinically effective serum level is in the range on 2-10 micrograms/ml. 3) A steady state blood level is achieved by 2-5 days 4) Can be used in management of alchohol withdrawl syndrome 5) Is the drug of choice in absence seizures.

Last Answer : Answers-4 Phenytoin is an imidazolidine derivative.It relates to barbiturates in chemical structure. Clinically effective seum level is in the range on 10-20 micrograms/ml. A steady state blood level is achieved by 7-10 days.

The following abnormality in PRPP synthetase can cause primary gout: (A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these

Description : The following abnormality in PRPP synthetase can cause primary gout: (A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these

Last Answer : Answer : D

Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant

Description : Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant

Last Answer : Answer : C

Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in an autosomal dominant manner 4) can be reduced with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure

Description : Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in ... with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure

Last Answer : Answers-2 Hyperuricaemia may be due to increased purine intake, urate production or reduced urate clearance, and is most commonly due to the latter. Therefore it can occur in association with enhanced ... . Many of the uricosuric drugs may be detrimental in renal failure and may not be effective.

Complete hydrolysis of proteins produces : (a) Ammonia and carbon dioxide (b) Urea and uric acid (c) A mixture of amino acids (d) Glycogen and a fatty acid

Description : Complete hydrolysis of proteins produces : (a) Ammonia and carbon dioxide (b) Urea and uric acid (c) A mixture of amino acids (d) Glycogen and a fatty acid

Last Answer : A mixture of amino acids