Description : Amplification of dihydrofolate reductase gene may be brought about by (A) High concentrations of folic acid (B) Deficiency of folic acid (C) Low concentration of thymidylate (D) Amethopterin
Last Answer : Answer : D
Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Last Answer : Answer : B
Description : A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while ... therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system
Last Answer : D. Patient has folate reductase abnormality in the nervous system
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Last Answer : Answer : A
Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above
Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme
Description : A hypochromic microcytic anaemia which increases Fe, store in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive
Description : A hypochromic necrocytic anaemia with increase Fe stores in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive
Last Answer : Answer : C
Description : Succinylcholine can produce all except A) Induce malignant hyperthermia in susceptible patients B) Prolonged paralysis occurs in case of butyrylcholinesterase abnormalities (as succinylcholine is not metabolized) C) Tachycardia, particularly in children D) Increase intraocular pressure
Last Answer : Ans: C
Description : Infant i le convu ls ions due to lesser formation of gamma amino butyric acid from glutamic acid is seen in the deficiency of (A) Glutamate-dehydrogenase (B) Pyridoxine (C) Folic acid (D) Thiamin
Description : Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Description : Convulsive episodes occur when there is a severe deficiency of: (A) Pyridoxine (B) Folic acid (C) Thiamine (D) Riboflavin
Description : Megaloblastic anemia is caused by the deficiency of (A) Folic acid (B) Vitamin B6 (C) Iron (D) Protein
Description : Methyl malonic aciduria is seen in the deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Description : Convulsive episodes occur when there is a severe deficiency of (A) Pyridoxine (B) Folic acid (C) Thiamine (D) Riboflavin
Description : Anaemia can occur due to the deficiency of all the following except (A) Thiamin (B) Pyridoxine (C) Folic acid (D) Cyanocobalamin
Description : Folic acid deficiency can be diagnosed by increased urinary excretion of (A) Methylmalonate (B) Figlu (C) Cystathionine (D) Creatinine
Description : Worldwide, the most common vitamin deficiency is that of (A) Ascorbic acid (B) Folic acid (C) Vitamin A (D) Vitamin D
Last Answer : B
Description : Trials for gene therapy in human beings were first carried out, with considerable success, in a genetic disease called (A) Cystic fibrosis (B) Thalassemia (C) Adenosine deaminase deficiency (D) Lesch-Nyhan syndrome
Description : Ras proto-oncogene is converted into oncogene by (A) A point mutation (B) Chromosomal translocation (C) Insertion of a viral promoter upstream of the gene (D) Gene amplification
Description : Antibody diversity arises from (A) Gene amplification (B) Gene re-arrangement (C) Alternative splicing (D) All of these
Description : In human body, the cell growth and differentiation are highly controlled and regulated, but in cancer cells. (a) there is breakdown of these regulatory mechanism leading to formation of benign and malignant ... is mutated and produced in less amount (d) DNA is mutated and produced in less amount
Last Answer : Ans:(a)
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine
Last Answer : A. Epoetin
Description : Risk of neural tube defect in the offspring can be minimised in pregnant women receiving antiepileptic drugs by supplemental therapy with: A. Folic acid B. Vitamin A C. Vitamin E D. Pyridoxine
Last Answer : B. Vitamin A
Description : In Ames’ assay, liver homogenate is included in the culture medium because (A) It converts pro-carcinogens into carcinogens (B) Liver can metabolise histidine (C) Salmonella mainly infects liver (D) Liver is very susceptible to cancer
Description : Assertion `:` Deficiency of vitamin `B_(12)` and folic acid can cause anaemia. Reason `:-` Vitamin `B_(12)` and folic acid are essential for maturatio
Last Answer : Assertion `:` Deficiency of vitamin `B_(12)` and folic acid can cause anaemia. Reason `:-` Vitamin ... False. D. If both Assertion & Reason are false.
Description : What is folic acid? Why is the anemia caused by deficiency of folic acid known as megaloblastic anemia?
Last Answer : The folic acid (when ionized it is called folate) is a coenzyme that participates in the synthesis and duplication of DNA and for this reason it is fundamental for cell division. ... types of anemia are nutrient deficiency anemias. Nutrition Vitamins - Image Diversity: megaloblastic red blood cell
Description : Anaemia occurs due to the deficiency of (1) riboflavin (2) thiamine (3) folic acid (4) niacin
Last Answer : (3) folic acid Explanation: Anemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ... oxygen from the lungs to the capillaries, anemia leads to hypcoda (lack of oxygen) in organs.
Description : Folic acid: a. is water soluble b. is absorbed in the stomach c. deficiency leads to aplastic anaemia d. deficiency occurs with methatrexate treatment
Last Answer : is water soluble
Description : Vitamin B12: a. is essential for the metabolism of folic acid in the humans b. is attached to a glycoprotein in the circulation c. its deficiency is characterized by hypersegmentation of the neutrophils d. all above
Last Answer : all above
Description : Pellagra disease is caused by the deficiency of (a) niacin (b) tocopherol (c) riboflavin (d) folic acid
Last Answer : (a) niacin
Description : Patient with macrocytic anemia without megaloblast. What’s the most likely diagnosis: a. Folic acid b. Vitamin B12 deficiency c. Alcoholism
Last Answer : c. Alcoholism
Description : Patient came with low iron and high AST and high MCV no megaloblasts in the blood wt is the Dx? Alcohol Vitamin B12defeciency Folic acid deficiency Due to drugs
Last Answer : Alcohol
Last Answer : (A) Pyridoxine
Description : A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had ... be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin
Last Answer : B. Vitamin B12
Description : Megaloblastic anaemia occurs in: A. Vitamin B12 but not folic acid deficiency B. Folic acid but not Vitamin B12 deficiency C. Either Vitamin B12 or folic acid deficiency D. Only combined Vitamin B12 + folic acid deficiency
Last Answer : C. Either Vitamin B12 or folic acid deficiency
Description : Deficiency of which of the following causes chelosis : (a) Pyridoxine (b) Folic Acid (c) Niacin (d) Riboflavin
Last Answer : (d) Riboflavin
Last Answer : folic acid
Description : Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms
Description : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency of
Last Answer : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency ... tyrosine oxidase C. monaine oxidase D. monamine oxidase
Description : The first clinical gene therapy was given for treating (a) diabetes mellitus (b) chicken pox (c) rheumatoid arthritis (d) adenosine deaminase deficiency.
Last Answer : (d) adenosine deaminase deficiency.
Description : Which kind of therapy was given in 1990 to a four- year-old girl with adenosine deaminase (ADA) deficiency? (a) Gene therapy (b) Chemotherapy (c) Immunotherapy (d) Radiation therapy
Last Answer : (a) Gene therapy
Description : Match the following columns and select the correct option. Column-I Column-II (A) Bt cotton (i) Gene therapy (B) Adenosine (ii) Cellular defence deaminase deficiency (C) RNAi (iii) Detection of HIV infection (D) PCR (iv) Bacillus ... (i) (iv) (c) (ii) (iii) (iv) (i) (d) (i) (ii) (iii) (iv)
Last Answer : (a) (iv) (i) (ii) (iii)
Description : Explain the term Gene amplification. -Biology
Last Answer : An increase in the number of copies of a gene. There may also be an increase in the RNA and protein made from that gene. Gene amplification is common in cancer cells, and some amplified genes may cause cancer cells to grow or become resistant to anticancer drugs.
Description : What is gene amplification? -Biology
Last Answer : answer:
Description : Which one of the following statements concerning glucose-6-phosphate dehydrogenase deficiency is correct? (A) Young R.B.Cs, particularly reticulocytes, contain the highest enzyme activity cells show less enzyme ... PD gene (D) G-6-PD deficiency is precipitated by ingestion of drugs such as aspirin