Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase
Last Answer : Answer : A
Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive
Last Answer : Answer : B
Description : The first clinical gene therapy was given for treating (a) diabetes mellitus (b) chicken pox (c) rheumatoid arthritis (d) adenosine deaminase deficiency.
Last Answer : (d) adenosine deaminase deficiency.
Description : Which kind of therapy was given in 1990 to a four- year-old girl with adenosine deaminase (ADA) deficiency? (a) Gene therapy (b) Chemotherapy (c) Immunotherapy (d) Radiation therapy
Last Answer : (a) Gene therapy
Description : Match the following columns and select the correct option. Column-I Column-II (A) Bt cotton (i) Gene therapy (B) Adenosine (ii) Cellular defence deaminase deficiency (C) RNAi (iii) Detection of HIV infection (D) PCR (iv) Bacillus ... (i) (iv) (c) (ii) (iii) (iv) (i) (d) (i) (ii) (iii) (iv)
Last Answer : (a) (iv) (i) (ii) (iii)
Description : The genetic defect-adenosine deaminase (ADA) deficiency may be cured permanently by (a) administering adenosine deaminase activators (b) introducing bone marrow cells producing ADA into ... replacement therapy (d) periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
Last Answer : (b) introducing bone marrow cells producing ADA into cells at early embryonic stages
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Description : Lesch-Nyhan syndrome?
Last Answer : DefinitionLesch-Nyhan syndrome is an inheritable disorder that affects how the body builds and breaks down purines. Purines are a normal part of human tissue and help make up the body's genetic blueprint. ... to develop gout-like swelling in some of their joints. In some cases, kidney and bl
Description : Which kind of therapy was given in 1990 to a four year old girl with adenosine deaminase (ADA) deficiency?
Last Answer : Which kind of therapy was given in 1990 to a four year old girl with adenosine deaminase (ADA ... B. radiation therapy C. gene therapy D. chemotherapy
Description : Which of the following genetic disorders in man are caused by a dominant gene? 1. Edwards Syndrome 2. Huntington's disease 3. Marfan Syndrome 4. Thalassemia Select the correct answer using codes given below: (a) 1 and 3 (b) 1 and 4 (c) 2 and 3 (d) 2 and 4
Last Answer : Ans:(c)
Description : Which of the following human genetic disorders is sexlinked? (1) Haemophilia (2) Cystic fibrosis (3) Albinism (4) PKU
Last Answer : (1) Haemophilia Explanation: Haemophilia is a group of hereditary genetic disorders that impairs the body's ability to control blood clotting, which is used to stop bleeding when a blood vessel is broken. It is a sex-linked recessive disorder which is more likely to occur in males than females.
Description : Which of the following human genetic disorders is sex-linked ? (1) Haemophilia (2) Cystic fibrosis (3) Albinism (4) PKU
Last Answer : Haemophilia
Description : Inherited deficiency of adenosine deaminase causes (A) Hyperuricaemia and gout (B) Mental retardation (C) Immunodeficiency (D) Dwarfism
Last Answer : Answer : C
Description : Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase
Last Answer : Answer : D
Description : An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase
Description : All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease
Description : What is Adenosine deaminase (ADA) deficiency? -Biology
Last Answer : answer:
Description : Down Syndrome, a congenital genetic disorder in human beings, is cased by : (a) a defective recessive gene in homozygous condition (b) an extra x chromosome (c) trisomy of chromosome 18 (d) trisomy of chromosome 21
Last Answer : Ans:(d)
Description : Which of the following is a Dominant Autosomal Disorder? (1) Albinism (2) Cystic Fibrosis (3) Phenyl Ketorunia (4) Alzheimer's Disease
Last Answer : (4) Alzheimer's Disease Explanation: In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes). The early-onset form of Alzheimer ... the disorder. In most cases, an affected person inherits the altered gene from one affected parent.
Description : .Which of the following is not a hereditary disease? (a) Cystic fibrosis (b) Thalassaemia (c) Haemophilia (d) Cretinism
Last Answer : (d) Cretinism
Description : Which of the following is a Dominant Autosomal Disorder? (1) Albinism (2) Cystic Fibrosis (3) Phenyl Ketorunia (4) Alzheimer’s Disease
Last Answer : Alzheimer’s Disease
Description : A synthetic nucleotide analogue, 4-hydroxypyrazolopyrimidine is used in the treatment of (A) Acute nephritis (B) Gout (C) Cystic fibrosis of lung (D) Multiple myeloma
Description : Sweat chlorides are increased in (A) Cystic fibrosis (B) Pancreatic cancer (C) Acute pancreatitis (D) None of these
Description : Mammals other than higher primates do not suffer from gout because they (A) Lack xanthine oxidase (B) Lack adenosine deaminase (C) Lack purine nucleoside phosphorylase (D) Possess uricase
Description : The enzyme common to catabolism of all the purines is (A) Adenosine deaminase (B) Purine nucleoside phosphorylase (C) Guanase (D) None of these
Description : Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome
Description : Who is the best doctor, who specializes in cystic fibrosis, in the world?
Last Answer : Here are several options for adults (I am making that assumption, correct me if I am wrong). If you have a specific location in mind, let me know, I might have some ideas. San Francisco UCSF Denver National Jewish Baltimore Johns Hopkins Pittsburgh University of Pittsburgh
Description : Cystic fibrosis?
Last Answer : DefinitionCystic fibrosis is an inherited disease that causes thick, sticky mucus to build up in the lungs and digestive tract. It is one of the most common chronic lung diseases in children and ... and serious digestion problems. The disease may also affect the sweat glands and a man's reproduct
Description : Can Cystic fibrosis be prevented?
Last Answer : Cystic Fibrosis cannot be prevented. It is an inherited disease, so there is no possible way to prevent something inherited. One parent will be a carrier and so will the other parent, therefore resulting in the child having CF.
Description : Nondisjunction of a chromosome results in which of the following diagnoses? a) Down Syndrome When a pair of chromosomes fails to separate completely and creates a sperm or oocyte that contains two ... genetic condition that may occur in a single family member as a result of spontaneous mutation.
Last Answer : a) Down Syndrome When a pair of chromosomes fails to separate completely and creates a sperm or oocyte that contains two copies of a particular chromosome (nondisjunction) Down syndrome results from three number 21 chromosomes.
Description : Ehlers-Danlos syndrome characterized by hypermobile joints and skin abnormalities is due to (A) Abnormality in gene for procollagen (B) Deficiency of lysyl oxidase (C) Deficiency of prolyl hydroxylase (D) Deficiency of lysyl hydroxylase
Description : Amplification of dihydrofolate reductase gene in a cancer cell makes the cell (A) Susceptible to folic acid deficiency (B) Less malignant (C) Resistant to amethopterin therapy (D) Responsive to amethopterin therapy
Description : Which of the following statements about septic shock are true? A. A circulating myocardial depressant factor may account for the cardiac dysfunction sometimes seen with shock due to sepsis or ... animal studies that demonstrate a significant improvement in survival with the use of such agents.
Last Answer : Answer: AB DISCUSSION: Shock due to sepsis or SIRS frequently manifests as a hyperdynamic cardiovascular response, consisting of an elevated CI and a decreased SVR or SVRI. Occasionally, ... been encouraging thus far in human clinical trials, despite the promising results from many animal studies
Description : Which one of the following is the correct statement for respiration in humans? (a) Cigarette smoking may lead to inflammation of bronchi. (b) Neural signals from pneumotoxic centre in pons region ... . (d) About 90% of carbon dioxide (CO2) is carried by haemoglobin as carbamino-haemoglobin.
Last Answer : (c) Workers in grinding and stone-breaking industries may suffer from lung fibrosis.
Description : Which one of the following is the correct statement for respiration in humans ? (1) About 90% of carbon dioxide (CO2 ) is carried by haemoglobin as carbamino-haemoglobin (2) Cigarette smoking ... of inspiration (4) Workers in grinding and stone-breaking industries may suffer, from lung fibrosis.
Last Answer : (4) Workers in grinding and stone-breaking industries may suffer, from lung fibrosis.
Description : A 75 year old man presents with a long history of shortness of breath and ankle oedema. His serum biochemistry shows sodium 122 mmols/l and potassium of 2.9 mmols/l. He now complains of ... ? 1) Addison's Disease 2) Nephrotic syndrome 3) Primary hyperaldosteronism 4) SIADH 5) Diuretic therapy
Last Answer : Answers-5 The long history of his symptoms and serum biochemistry suggests that his condition is due to treatment with frusemide for CCF.
Description : Genetic information in human beings is stored in (A) RNA (B) DNA (C) Both (A) and (B) (D) mRNA
Description : Genetic information in human beings is stored in (A) DNA (B) RNA (C) Both (A) and (B) (D) None of these
Description : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency of
Last Answer : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency ... tyrosine oxidase C. monaine oxidase D. monamine oxidase
Description : Megaloblastic anaemia developing under the following condition is due entirely to folate deficiency not associated with vitamin B12 deficiency: A. Malnutrition B. Blind loop syndrome C. Phenytoin therapy D. Pregnancy
Last Answer : C. Phenytoin therapy
Description : In the nutritional support of patients with cancer, which of the following statements is/are true? A. Nutritional support benefits the patient's lean body mass but does not enable ... with cancer about to undergo surgery revealed decreased morbidity and mortality, especially morbidity from sepsis.
Last Answer : Answer: B DISCUSSION: The problem with the patient with cancer is a very vexing one. Clearly, one of the metabolic effects of cancer, cachexia, affects patients in the last quartile ... undoubtedly reveal that there are certain nutrients that tumors require, which probably should be best avoided
Description : Deficiency of pantothenic acid in human beings can affect (A) Nervous system (B) Digestive system (C) Both (A) and (B) (D) None of these
Description : What kind of disease is thalassemia ?
Last Answer : Thalassemia is an abnormal disease of red blood cells.
Description : Thalassemia is a hereditary disease. It affects - (1) Blood (2) Spleen (3) Lungs (4) Heart
Last Answer : (1) Blood Explanation: Thalassemia are forms of inherited autosomal recessive blood disorders that originated in the Mediterranean region. In thalassemia, the disease is caused by the weakening and destruction ... against malaria, which is or was prevalent in the regions where the trait is common.
Description : Thalassemia is a hereditary disease. It affects (1) Blood (2) Spleen (3) Lungs (4) Heart
Last Answer : Blood
Description : Pick out the correct statements. (1) Haemophilia is a sex-linked recessive disease. (2) Down's syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anaemia is an X- ... are correct. (c) (1) and (4) are correct. (d) (2) and (4) are correct.
Last Answer : (b) (1), (2) and (3) are correct.
Description : .In human beings 45 chromosomes/single X/XO abnormality causes (a) Down’s syndrome (b) Kinefelter’s syndrome (c) Turner’s syndrome (d) Edward’s syndrome
Last Answer : (c) Turner’s syndrome
Description : .In Drosophila, the XXY condition leads to femaleness whereas in human beings the same condition leads to Klinefelter's syndrome in male. It proves (a) in human beings Y chromosome is active in ... (c) in Drosophila Y chromosome decides femaleness (d) Y chromosome of man have genes for syndrome.
Last Answer : (a) in human beings Y chromosome is active in sex determination
Description : Epinephrine is rapidly metabolized by (A) Monoamine oxidase (B) Deaminase (C) Transminase (D) Decarboxylase
Description : In thalassemia, an amino acid is substituted in (A) Alpha chain (B) Beta chain (C) Alpha and beta chains (D) Any chain MINERAL METABOLISM 195