Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Last Answer : Answer : B
Description : Amplification of dihydrofolate reductase gene in a cancer cell makes the cell (A) Susceptible to folic acid deficiency (B) Less malignant (C) Resistant to amethopterin therapy (D) Responsive to amethopterin therapy
Last Answer : Answer : C
Description : Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase
Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above
Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Last Answer : Answer : A
Description : A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while ... therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system
Last Answer : D. Patient has folate reductase abnormality in the nervous system
Description : Patient came with low iron and high AST and high MCV no megaloblasts in the blood wt is the Dx? Alcohol Vitamin B12defeciency Folic acid deficiency Due to drugs
Last Answer : Alcohol
Description : Infant i le convu ls ions due to lesser formation of gamma amino butyric acid from glutamic acid is seen in the deficiency of (A) Glutamate-dehydrogenase (B) Pyridoxine (C) Folic acid (D) Thiamin
Description : Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Last Answer : Answer : D
Description : Convulsive episodes occur when there is a severe deficiency of: (A) Pyridoxine (B) Folic acid (C) Thiamine (D) Riboflavin
Description : Megaloblastic anemia is caused by the deficiency of (A) Folic acid (B) Vitamin B6 (C) Iron (D) Protein
Description : Methyl malonic aciduria is seen in the deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12
Description : Convulsive episodes occur when there is a severe deficiency of (A) Pyridoxine (B) Folic acid (C) Thiamine (D) Riboflavin
Description : Anaemia can occur due to the deficiency of all the following except (A) Thiamin (B) Pyridoxine (C) Folic acid (D) Cyanocobalamin
Description : Folic acid deficiency can be diagnosed by increased urinary excretion of (A) Methylmalonate (B) Figlu (C) Cystathionine (D) Creatinine
Description : Worldwide, the most common vitamin deficiency is that of (A) Ascorbic acid (B) Folic acid (C) Vitamin A (D) Vitamin D
Last Answer : B
Description : Ras proto-oncogene is converted into oncogene by (A) A point mutation (B) Chromosomal translocation (C) Insertion of a viral promoter upstream of the gene (D) Gene amplification
Description : Antibody diversity arises from (A) Gene amplification (B) Gene re-arrangement (C) Alternative splicing (D) All of these
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : The rate of an enzyme catalyzed reaction was measured using several substrate concentrations that were much lower than Km, the dependence of reaction velocity on substrate concentration can best be ... constant fraction of Vmax (C) Equal to Km (D) Proportional to the substrate concentration
Description : The order of reaction is the number of moles whose concentrations determine the rate of a reaction at a given temperature Give the integrated equation for first order reaction. K = (2.303 / t) * log (a ... a' is the initial concentration of reactants x' is the amount reacted in time t seconds
Last Answer : What is Threshold energy ?
Description : Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate
Description : Assertion `:` Deficiency of vitamin `B_(12)` and folic acid can cause anaemia. Reason `:-` Vitamin `B_(12)` and folic acid are essential for maturatio
Last Answer : Assertion `:` Deficiency of vitamin `B_(12)` and folic acid can cause anaemia. Reason `:-` Vitamin ... False. D. If both Assertion & Reason are false.
Description : What is folic acid? Why is the anemia caused by deficiency of folic acid known as megaloblastic anemia?
Last Answer : The folic acid (when ionized it is called folate) is a coenzyme that participates in the synthesis and duplication of DNA and for this reason it is fundamental for cell division. ... types of anemia are nutrient deficiency anemias. Nutrition Vitamins - Image Diversity: megaloblastic red blood cell
Description : Anaemia occurs due to the deficiency of (1) riboflavin (2) thiamine (3) folic acid (4) niacin
Last Answer : (3) folic acid Explanation: Anemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ... oxygen from the lungs to the capillaries, anemia leads to hypcoda (lack of oxygen) in organs.
Description : Folic acid: a. is water soluble b. is absorbed in the stomach c. deficiency leads to aplastic anaemia d. deficiency occurs with methatrexate treatment
Last Answer : is water soluble
Description : Vitamin B12: a. is essential for the metabolism of folic acid in the humans b. is attached to a glycoprotein in the circulation c. its deficiency is characterized by hypersegmentation of the neutrophils d. all above
Last Answer : all above
Description : Pellagra disease is caused by the deficiency of (a) niacin (b) tocopherol (c) riboflavin (d) folic acid
Last Answer : (a) niacin
Description : Patient with macrocytic anemia without megaloblast. What’s the most likely diagnosis: a. Folic acid b. Vitamin B12 deficiency c. Alcoholism
Last Answer : c. Alcoholism
Last Answer : (A) Pyridoxine
Description : A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had ... be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin
Last Answer : B. Vitamin B12
Description : Megaloblastic anaemia occurs in: A. Vitamin B12 but not folic acid deficiency B. Folic acid but not Vitamin B12 deficiency C. Either Vitamin B12 or folic acid deficiency D. Only combined Vitamin B12 + folic acid deficiency
Last Answer : C. Either Vitamin B12 or folic acid deficiency
Description : Deficiency of which of the following causes chelosis : (a) Pyridoxine (b) Folic Acid (c) Niacin (d) Riboflavin
Last Answer : (d) Riboflavin
Last Answer : folic acid
Description : The metabolic reaction requiring vitamin B12 but not folate is: A. Conversion of malonic acid to succinic acid B. Conversion of homocysteine to methionine C. Conversion of serine to glycine D. Thymidylate synthesis
Last Answer : A. Conversion of malonic acid to succinic acid
Description : A hypochromic microcytic anaemia which increases Fe, store in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive
Description : A hypochromic necrocytic anaemia with increase Fe stores in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive
Description : Explain the term Gene amplification. -Biology
Last Answer : An increase in the number of copies of a gene. There may also be an increase in the RNA and protein made from that gene. Gene amplification is common in cancer cells, and some amplified genes may cause cancer cells to grow or become resistant to anticancer drugs.
Description : What is gene amplification? -Biology
Last Answer : answer:
Description : Molybdenum deficiency affects the activity of – (1) All of the given options (2) Chlorate reductase (3) Nitrogenase (4) Nitrate reductase
Last Answer : (4) Nitrate reductase Explanation: Numerous investigators have shown that nitrate nitrogen accumulates in higher plants and fungi which are deficient in molybdenum. In molybdenum-deficient plants grown in the ... in the decrease of free amino acids in the plants in comparison to normal plants.
Description : Molybdenum deficiency affects the activity of : (1) All of the given options (2) Chlorate reductase (3) Nitrogenase (4) Nitrate reductase
Last Answer : Nitrate reductase
Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate
Description : Retinal is converted into retinoic acid in the presence of (A) Retinal oxidase (B) Retinal carboxylase (C) Retinene reductase(D) Spontaneously
Description : Oxaloacetate is converted to aspartic acid by (A) Reductase (B) Oxidase (C) Transminase (D) Catalase
Description : For the reaction `a+brArrc+d`, initially concentrations of a and b are equal and at equilibrium the concentration of a . What will be the equilibrium
Last Answer : For the reaction `a+brArrc+d`, initially concentrations of a and b are equal and at equilibrium the concentration of a ... ? A. 2 B. 9 C. 4 D. 3
Description : . A first order irreversible reaction, A → B is carried out separately in a constant volume as well as in a variable volume reactor for a particular period. It signifies that __________ in the two ... be different (C) Both the conversion as well as concentrations will be different (D) None of these
Last Answer : (B) Conversion in both will be the same but concentrations will be different