Methods of sciatica pain relief include taking over-the-counter anti-inflammatory medications, prescription pain medications and physical therapy treatments. In addition, during the acute phase, resting may help alleviate symptoms. Sciatica can cause excruciating pain that starts in the lower back and radiates down the buttock and back of the leg. Another example of sciatica pain relief is applying hot compresses or a heating pad to the affected area. In addition, applying an ice pack to the painful area might also help improve symptoms.