Damage to nerves of the peripheral nervous system is called peripheral neuropathy. It can have a number of causes, but the most common cause is Diabetes. It can also have a number of symptoms. Weakness, muscle cramping, numbness and a pins-and-needles sensation can occur. Pain is the most troublesome symptom and can appear as a burning or freezing sensation, or as a deep, intense itching that cannot be scratched. Areas affected by peripheral neuropathy can become extremely sensitive to light touch. A sock or shoe touching the foot can feel as if it has an electrical current running through it. Unfortunately, most treatments merely control symptoms rather the root cause. Here are the most popular treatments:Oral MedicationsAnti-seizure medications can keep the nerves from firing so intensely. Pregabalin, marketed under the brand name Lyrica, is one of the most successful treatments. Lyrica is expensive since the generic form is not yet available. For patients who don't have pharmaceutical insurance coverage, Gabapentin, the generic equivalent of Neurontin, also works well and is far less expensive. Patients do have to take larger doses of Neurontin to get the equivalent effect of Lyrica.Some anti-depressants are effective against peripheral neuropathy and can help relieve the depression that can accompany chronic pain. Duloxetine, a serotonin-norepinephrin reuptake inhibitor (SNRI) sold under the brand name Cymbalta, also helps the pain of peripheral neuropathy. Some patients find tricyclic antidepressants such as amitriptyline to be helpful.Topical MedicationsLidocaine patches contain a numbing agent and can be applied to the painful areas. Capsaicin is another topical agent that some people find helpful, although it can cause burning pain when the treated area is exposed to the hot water of a shower or bath.TherapiesTranscutaneous electrical nerve stimulation (TENS) may help to alleviate pain. Electrodes are placed on the skin and a mild electrical current is delivered. This therapy is usually given first by a physical therapist and then continued at home. TENS must be applied frequently to be effective. Short wave diathermy also helps some patients with diabetic neuropathy.SupplementsAlpha-lipoic acid is an antioxidant that some find helps their symptoms. Since B-vitamin deficiency may cause or exacerbate peripheral neuropathy, supplements of these vitamins can help those who don't get enough from their diets.