Description : The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation
Last Answer : C. Lipid solubility of the drug
Description : The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium
Last Answer : A. Blood flow through the capillary
Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion
Last Answer : B. Plasma protein binding
Description : The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding
Last Answer : C. High plasma protein binding
Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance
Last Answer : D. Total body clearanc
Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites
Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites
Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Last Answer : D. Redistribution
Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa
Last Answer : B. Altering gut motility
Description : Which of the following statements is not true of fixed dose combination formulations: A. They are more convenient B. Contraindication to one of the components does not contraindicate the formulation ... adjusted D. The time course of action of the different components may not be identical
Last Answer : B. Contraindication to one of the components does not contraindicate the formulation
Description : Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs
Last Answer : A. Highly lipid soluble drugs
Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood
Last Answer : D. It regulates passage of substances from brain into blood
Description : Which of the following adverse drug reactions is due to a specific genetic abnormality: A. Tetracycline induced sunburn like skin lesions B. Quinidine induced thrombocytopenia C. Metoclopramide induced muscle dystonia D. Primaquine induced massive haemolysis
Last Answer : D. Primaquine induced massive haemolysis
Description : If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of: A. × 3 B. × 2 C. × 1.5 D. × 1.3
Last Answer : B. × 2
Last Answer : D. Total body clearance
Description : Reflex bronchoconstriction is most likely to occur with the following form of inhaled antiasthma medication: A. Metered dose spray of drug in solution B. Dry powder rotacap C. Nebuliser D. Nebuliser with spacer
Last Answer : B. Dry powder rotacap
Description : Select the drug which has been found to be a strong human teratogen: A. Isoniazid B. Isotretinoin C. Hydralazine D. Propylthiouracil
Last Answer : B. Isotretinoin
Description : Adverse consequences may follow sudden discontinuation of the following drug after chronic intake: A. Cocaine B. Cannabis C. Clonidine D. All of the above
Last Answer : C. Clonidine
Description : An addicting drug which produces little or no physical dependence is: A. Diazepam B. Phenobarbitone C. Amphetamine D. Methadone
Last Answer : C. Amphetamine
Description : Intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity: A. Type I (anaphylactic) B. Type II (cytolytic) C. Type III (retarded) D. All of the above
Last Answer : A. Type I (anaphylactic)
Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals
Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning
Description : A ‘toxic effect’ differs from a ‘side effect’ in that: A. It is not a pharmacological effect of the drug B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication C. It must involve drug induced cellular injury D. It involves host defence mechanisms
Last Answer : B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication
Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin
Last Answer : A. Constipation caused by codeine
Description : Which of the following is a type B (unpredictable) adverse drug reaction: A. Side effect B. Toxic effect C. Idiosyncrasy D. Physical dependence
Last Answer : A. Side effect
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Description : In patients with renal insufficiency the clearance of the following drug is reduced parallel to the reduction in creatinine clearance: A. Propranolol B. Digoxin C. Lignocaine D. Verapamil
Last Answer : B. Digoxin
Description : The following drug adverse effect is specially noted in men compared to women: A. Tardive dyskinesia due to neuroleptics B. Levodopa induced abnormal movements C. Ampicillin induced loose motions D. Ketoconazole induced loss of libido
Last Answer : D. Ketoconazole induced loss of libido
Description : Which adverse drug effect is more common in children than in adults: A. Isoniazid induced neuropathy B. Chlorpromazine induced muscle dystonia C. Digoxin induced cardiac arrhythmia D. Penicillin hypersensitivity
Last Answer : B. Chlorpromazine induced muscle dystonia
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : Interindividual variations in equieffective doses of a drug are most marked if it is disposed by: A. Glomerular filtration B. Tubular secretion C. Both glomerular filtration and tubular secretion D. Hepatic metabolism
Last Answer : D. Hepatic metabolism
Description : A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist
Last Answer : C. Noncompetitive antagonist
Description : A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist
Last Answer : C. Competitive antagonist
Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)
Last Answer : C. Diazepam (pentobarbitone)
Description : The therapeutic index of a drug is a measure of its: A. Safety B. Potency C. Efficacy D. Dose variability
Last Answer : A. Safety
Description : If the dose-response curves of a drug for producing different actions are widely separated on the dose axis, the drug is: A. Highly potent B. Highly efficacious C. Highly toxic D. Highly selective
Last Answer : D. Highly selective
Description : Higher efficacy of a drug necessarily confers: A. Greater safety B. Therapeutic superiority C. Capacity to produce more intense response D. Cost saving
Last Answer : C. Capacity to produce more intense response
Description : Which of the following is always true: A. A more potent drug is more efficacious B. A more potent drug is safer C. A more potent drug is clinically superior D. A more potent drug can produce the same response at lower doses
Last Answer : D. A more potent drug can produce the same response at lower doses
Description : ‘Drug efficacy’ refers to: A. The range of diseases in which the drug is beneficial B. The maximal intensity of response that can be produced by the drug C. The dose of the drug needed to produce half maximal effect D. The dose of the drug needed to produce therapeutic effect
Last Answer : B. The maximal intensity of response that can be produced by the drug
Description : The following statement is not true of potency' of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by ... consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response
Last Answer : D. It reflects the capacity of the drug to produce a drastic response