Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Which of the following is not true of the blood-brain
barrier:
A. It is constituted by tight junctions between
the endothelial cells of brain capillaries and
the glial tissue
B. It allows passage of lipid soluble drugs into
the brain
C. It limits entry of highly ionized drugs into the brain
D. It regulates passage of substances from brain
into blood
by

1 Answer

Answer :

D. It regulates passage of substances from brain
into blood
by

Related questions

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

6 The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : 6 The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium

Description : The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium

Last Answer : A. Blood flow through the capillary

The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium

Description : The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium

Last Answer : A. Blood flow through the capillary

The blood-brain-barrier: a. contains the foot processes of astrocytes b. contains endothelial cells with tight junction c. allows transport in one direction only ie from the vascular system into the brain d. does not allow diffusion of water

Description : The blood-brain-barrier: a. contains the foot processes of astrocytes b. contains endothelial cells with tight junction c. allows transport in one direction only ie from the vascular system into the brain d. does not allow diffusion of water

Last Answer : does not allow diffusion of water

Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Description : Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Last Answer : A. Highly lipid soluble drugs

Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Description : Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Last Answer : A. Highly lipid soluble drugs

Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Description : Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs

Last Answer : A. Highly lipid soluble drugs

The following are true about blood-brain barrier: a. it is permeable at birth b. it involves tight junction between endothelial cells and end feet processes of astrocytes c. it is absent in the posterior pituitary d. all above

Description : The following are true about blood-brain barrier: a. it is permeable at birth b. it involves tight junction between endothelial cells and end feet processes of astrocytes c. it is absent in the posterior pituitary d. all above

Last Answer : all above

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Description : The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Last Answer : all above

The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Description : The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Last Answer : all above

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Last Answer : D. Redistribution

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Last Answer : D. Redistribution

With regard to the blood retina barrier: a. the outer blood retina is formed by the retinal pigment epithelium cells and their junctions b. the blood retina barrier is typically defective in the immediate perpapillary region c. the retinal vascular endothelial cells can actively transport fluid and anions from the extracellular space of the retina into the circulation d. all above

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05. What kind of substances can’t permeate membranes by passive diffusion? a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances 06. A hydrophilic medicinal agent

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Read the following (A - D) stetements :- (A) Tight junctions help to stop substances from leaking across a tissue (B) Adhering junctions perform cemen

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Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier

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Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

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Last Answer : A. They do not cross the blood-brain barrier

Which of the following statements regarding endothelial cells in acute inflammation are true? a. Endothelial cells are characterized by phenotypic homogeneity b. Specific patterns of receptor expression regulate leukocyte adherence c. Endothelial cell nitric oxide generation regulates regional blood flow and leukocyte adhesion d. Endothelial cells may be capable of phagocytosis

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The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

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The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

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Last Answer : C. High plasma protein binding

Glucose entry into the cells of the following organ/ tissue is highly dependent on the presence of insulin: A. Brain B. Liver C. Adipose tissue D. Kidney tubules

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What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

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The cell junctions called tight, adhering and gap junctions are found in (a) connective tissue (b) epithelial tissue (c) neural tissue (d) muscular tissue

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The basic structure of cell membranes (a) Is a lipid bilayer that serves as a barrier to water soluble molecules (b) Differs ultra structurally for internal and external membranes of cell (c) Is best described as lipids dispersed within a protein bilayer (d) Is visualised as bilaminar structure with transmission electron microscopy

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Last Answer : Ans:(a)

Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Last Answer : B. Plasma protein binding

The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation

Description : The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation

Last Answer : C. Lipid solubility of the drug

The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation

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Last Answer : C. Lipid solubility of the drug

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

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Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Last Answer : B. Plasma protein binding

The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation

Description : The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation

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A striking feature of living cells is a marked difference between the composition of the cytosol and the extracellular milieu. Which of the following statement(s) concerning the mechanisms of maintenance of these differences is/are true? a. The cell membrane is able to maintain a 10,000 fold gradient between the extracellular concentration of ionized calcium and the intracellular concentration b. The key to these differences is the fact that the plasma membrane is normally impermeable to sodium, potassium and calcium c. The selectivity of biologic membranes is highly consistent and seldom changes d. The selectivity of cell membranes relates only to ions and not organic compounds

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Last Answer : Answer: a The survival of the cell requires that cytosolic composition be maintained within narrow limits, despite the constant influx of nutrients and the simultaneous outflow of waste. A ... be altered drastically as a result of regulatory or signaling processes that occur within the cell

The ability of the cell membrane to act as a selective barrier depends upon (A) The lipid composition of the membrane (B) The pores which allows small molecules (C) The special mediated transport systems (D) All of these

Description : The ability of the cell membrane to act as a selective barrier depends upon (A) The lipid composition of the membrane (B) The pores which allows small molecules (C) The special mediated transport systems (D) All of these

Last Answer : D

The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo

Which of the following statement(s) is/are correct concerning cell junctions? a. The major occluding junction is the tight junction or zonula occludens b. Tight junctions are usually located near the basal pole of the cell c. Desmosomes are button-like points of attachment which serve to weld together adjacent cells d. Gap junctions are a type of cell junction specialized for cell communication

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5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Last Answer : D. Redistribution

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened

Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these drugs C. Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

Description : Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these ... Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

Last Answer : B. It is easier to measure the effect of these drugs