Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa
Last Answer : B. Altering gut motility
Description : Anticancer drugs weaken host defence by: A. Damaging respiratory and gut epithelia B. Inducing granulocytopenia C. Altering resident microbial flora D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : The dose of the following class of drugs has to be adjusted by repeated measurement of the affected physiological parameter: A. Oral contraceptives B. Antiepileptics C. Antidepressants D. Oral anticoagulants
Last Answer : D. Oral anticoagulants
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : Limitations of typical tricyclic antidepressants include the following except: A. Narrow safety margin B. Low oral bioavailability C. Frequent side effects D. Long latent period for response
Last Answer : B. Low oral bioavailability
Description : The success of oral rehydration therapy of diarrhoea depends upon the following process in the intestinal mucosa: A. Sodium pump mediated Na+ absorption B. Glucose coupled Na+ absorption C. Bicarbonate coupled Na+ absorption D. Passive Na+ diffusion secondary to nutrient absorption
Last Answer : B. Glucose coupled Na+ absorption
Description : Tricyclic antidepressants abolish the antihypertensive action of the following drug: A. Enalapril B. Clonidine C. Atenolol D. Diltiazem
Last Answer : B. Clonidine
Description : Which type of diarrhea is caused by increased production and secretion of water and electrolyes by the intestinal mucosa into the intestinal lumen? a) Secretory diarrhea Secretory diarrhea is usually ... bowel. d) Diarrheal disease The most common cause of diarrheal disease is contaminated food.
Last Answer : a) Secretory diarrhea Secretory diarrhea is usually high volume diarrhea and is caused by increased production and secretion of water and electrolytes by the intestinal mucosa into the intestinal lumen.
Description : In patients of hepatic cirrhosis: A. The extent of change in pharmacokinetics of drugs can be predicted from the values of liver function tests B. High doses of furosemide can be safely used C. Metformin is the preferred oral hypoglycaemic D. Disposition of atenolol is not significantly affected
Last Answer : D. Disposition of atenolol is not significantly affected
Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination
Last Answer : A. Have low oral bioavailability
Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism
Last Answer : C. Is incompletely absorbed
Last Answer : C. Altering gut flora
Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites
Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form
Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal
Last Answer : A. Oral
Description : Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of ... 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache
Last Answer : Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings
Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals
Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning
Description : The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium
Last Answer : A. Blood flow through the capillary
Description : Irrespective of the type, all laxatives exert the following action: A. Increase the content of solids in the faeces B. Increase the water content of faeces C. Reduce absorption of nutrients D. Increase intestinal motility
Last Answer : B. Increase the water content of faeces
Description : The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation
Last Answer : C. Lipid solubility of the drug
Description : Indications of tricyclic antidepressants include the following except: A. Attention deficit-hyperactive disorder in children B. Mania C. Prophylaxis of migraine D. Panic disorder
Last Answer : B. Mania
Description : The tricyclic antidepressants are also effective in the following psychiatric disorders except: A. Schizophrenia B. Obsessive-compulsive disorder C. Bulimia D. Phobic states
Last Answer : A. Schizophreni
Description : Venlafaxine differs from standard tricyclic antidepressants in that it: A. Does not inhibit 5-HT reuptake B. Does not inhibit noradrenaline reuptake C. Does not have anticholinergic or antiadrenergic property D. Has lower antidepressant efficacy
Last Answer : C. Does not have anticholinergic or antiadrenergic property
Description : The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently ... suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines
Last Answer : D. It does not block neuronal uptake of biogenic amines
Description : The mechanisms involved in the causation of dangerous cardiac arrhythmias due to overdose of tricyclic antidepressants include the following except: A. Intraventricular conduction block B. Potentiation of noradrenaline C. Antagonism of acetylcholine D. Increased vagal tone
Last Answer : D. Increased vagal tone
Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)
Last Answer : C. Diazepam (pentobarbitone)
Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable
Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable
Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor
Last Answer : C. Agonists induce a conformational change in the receptoR
Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation
Last Answer : C. An inactive drug that is transformed in the body to an active metabolite
Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites
Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites
Description : 3 Diffusion of drugs across cell membrane: A. Is dependent upon metabolic activity of the cell B. Is competitively inhibited by chemically related drugs C. Is affected by extent of ionization of drug molecules D. Exhibits saturation kinetics
Last Answer : C. Is affected by extent of ionization of drug molecules
Last Answer : C. Agonists induce a conformational change in the receptor
Description : Monitoring plasma drug concentration is useful while using: A. Antihypertensive drugs B. Levodopa C. Lithium carbonate D. MAO inhibitors
Last Answer : C. Lithium carbonate
Description : Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2
Last Answer : A. CYP 3A4
Description : From the internal surface to the external surface, the digestive tube wall is made of mucosa (epithelial tissue responsible for the intestinal absorption), submucosa (connective tissue beneath the ... within the abdominal cavity. Digestion System - Image Diversity: histology of the digestive tube
Last Answer : What is the location of the salivary glands in humans?
Description : The gut controls the entry of ingested iron in the body by: A. Regulating the availability of apoferritin which acts as the carrier of iron across the mucosal cell B. Regulating the turnover of ... mucosal cell and is shed off D. Regulating the number of transferrin receptors on the mucosal cell
Last Answer : C. Complexing excess iron to form ferritin which remains stored in the mucosal cell and is shed off
Description : Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic ... (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well
Last Answer : Ans: A