Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion
Last Answer : B. Plasma protein binding
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : D. Tubular transport mechanisms are not well developed
Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance
Last Answer : D. Total body clearanc
Description : If a drug undergoes net tubular secretion, its renal clearance will be: A. More than the glomerular filtration rate B. Equal to the glomerular filtration rate C. Less than the glomerular filtration rate D. Equal to the rate of urine formation
Last Answer : A. More than the glomerular filtration rate
Description : The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding
Last Answer : C. High plasma protein binding
Description : High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting
Last Answer : D. Generally makes the drug long acting
Description : Interindividual variations in equieffective doses of a drug are most marked if it is disposed by: A. Glomerular filtration B. Tubular secretion C. Both glomerular filtration and tubular secretion D. Hepatic metabolism
Last Answer : D. Hepatic metabolism
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Last Answer : D. Redistribution
Description : The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed
Last Answer : Ans: D
Last Answer : D. Total body clearance
Description : Inulin clearance is a measure of (A) Glomerular filtration rate (B) Tubular secretion flow (C) Tubular reabsorption rate (D) Renal plasma flow
Last Answer : Answer : B
Description : Para-amino hippurate excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal plasma flow
Last Answer : Answer : D
Description : The most important factor governing absorption of a drug from intact skin is: A. Molecular weight of the drug B. Site of application C. Lipid solubility of the drug D. Nature of the base used in the formulation
Last Answer : C. Lipid solubility of the drug
Description : The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium
Last Answer : A. Blood flow through the capillary
Description : The Tm for PAH i.e the maximal secretory capacity of the tubule for PAH can be used to gavge the (A) Extent of tubular damage FATS AND FATTY ACID METABOLISM 81 (B) Impairment of the capacity of the tubule to perform osmotic work (C) Impairment of renal plasma flow (D) Glomerular filtration rate
Last Answer : Answer : A
Description : Creatinine EDTA clearance is a test to measure (A) Renal plasma flow (B) Filtration fraction (C) Glomerular filtration rate (D) Tubular function
Last Answer : Answer : C
Description : Measurement of insulin clearance test is a measure of (A) Glomerular filtration rate (B) Filtration factor (C) Renal plasma flow (D) Tubular secretory mass
Description : Urea clearance test is used to determine the (A) Glomerular filtration rate (B) Renal plasma flow (C) Ability of kidney to concentrate the urine (D) Measurement of tubular mass
Description : 3 Diffusion of drugs across cell membrane: A. Is dependent upon metabolic activity of the cell B. Is competitively inhibited by chemically related drugs C. Is affected by extent of ionization of drug molecules D. Exhibits saturation kinetics
Last Answer : C. Is affected by extent of ionization of drug molecules
Description : Phenolsulphonephthalein excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal blood low
Description : The most important channel of elimination of digoxin is: A. Glomerular filtration B. Tubular secretion C. Hepatic metabolism D. Excretion in bile
Last Answer : A. Glomerular filtration
Description : In studies of the human body, which of the following terms is used to describe the first step in the production of urine? Is it: a) tubular secretion b) tubular reabsorption c) glomerular filtration d) none of these
Last Answer : ANSWER: C -- GLOMERULAR FILTRATION
Description : Marked redistribution is a feature of: A. Highly lipid soluble drugs B. Poorly lipid soluble drugs C. Depot preparations D. Highly plasma protein bound drugs
Last Answer : A. Highly lipid soluble drugs
Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate
Last Answer : (D) Glomerular filtration rate
Description : Induction of drug metabolizing enzymes involves: A. A conformational change in the enzyme protein to favour binding of substrate molecules B. Expression of enzyme molecules on the surface of ... C. Enhanced transport of substrate molecules into hepatocytes D. Increased synthesis of enzyme protein
Last Answer : D. Increased synthesis of enzyme protein
Description : The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver
Last Answer : D. Is not available for metabolism unless actively extracted by the liver
Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites
Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites
Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant
Last Answer : C. Volume of distribution
Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr
Last Answer : B. 2.0 L/hr