Description : Interindividual variations in equieffective doses of a drug are most marked if it is disposed by: A. Glomerular filtration B. Tubular secretion C. Both glomerular filtration and tubular secretion D. Hepatic metabolism
Last Answer : D. Hepatic metabolism
Description : Para-amino hippurate excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal plasma flow
Last Answer : Answer : D
Description : Phenolsulphonephthalein excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal blood low
Description : If a drug undergoes net tubular secretion, its renal clearance will be: A. More than the glomerular filtration rate B. Equal to the glomerular filtration rate C. Less than the glomerular filtration rate D. Equal to the rate of urine formation
Last Answer : A. More than the glomerular filtration rate
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : D. Tubular transport mechanisms are not well developed
Description : The Tm for PAH i.e the maximal secretory capacity of the tubule for PAH can be used to gavge the (A) Extent of tubular damage FATS AND FATTY ACID METABOLISM 81 (B) Impairment of the capacity of the tubule to perform osmotic work (C) Impairment of renal plasma flow (D) Glomerular filtration rate
Last Answer : Answer : A
Description : Inulin clearance is a measure of (A) Glomerular filtration rate (B) Tubular secretion flow (C) Tubular reabsorption rate (D) Renal plasma flow
Last Answer : Answer : B
Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion
Last Answer : B. Plasma protein binding
Description : In studies of the human body, which of the following terms is used to describe the first step in the production of urine? Is it: a) tubular secretion b) tubular reabsorption c) glomerular filtration d) none of these
Last Answer : ANSWER: C -- GLOMERULAR FILTRATION
Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate
Last Answer : (D) Glomerular filtration rate
Description : Which of the following processes plays the major role in terminating the action of phenobarbitone: A. Biliary excretion B. Renal excretion C. Hepatic metabolism D. Redistribution
Last Answer : B. Renal excretion
Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve
Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action
Description : 09. The reasons determing bioavailability are: a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass effect d) Glomerular filtration rate
Last Answer : C
Description : Creatinine EDTA clearance is a test to measure (A) Renal plasma flow (B) Filtration fraction (C) Glomerular filtration rate (D) Tubular function
Last Answer : Answer : C
Description : Measurement of insulin clearance test is a measure of (A) Glomerular filtration rate (B) Filtration factor (C) Renal plasma flow (D) Tubular secretory mass
Description : Urea clearance test is used to determine the (A) Glomerular filtration rate (B) Renal plasma flow (C) Ability of kidney to concentrate the urine (D) Measurement of tubular mass
Description : The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed
Last Answer : Ans: D
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl- cotransport in the ascending limb of loop of Henle C ... in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone
Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K
Description : The following is true for gentamicin: A. It is more active in acidic medium B. It has a wide margin of safety C. It is excreted unchanged, mainly by glomerular filtration D. It primarily inhibits gram positive bacteria
Last Answer : C. It is excreted unchanged, mainly by glomerular filtration
Description : The primary mechanism by which antidiuretic hormone reduces urine volume is: A. Decrease in glomerular filtration rate B. Decreased renal blood flow C. Decreased water permeability of descending limb of loop of Henle D. Increased water permeability of collecting duct cells
Last Answer : D. Increased water permeability of collecting duct cells
Description : Which of the following factors is responsible for the formation of concentrated urine? (a) Hydrostatic pressure during glomerular filtration. (b) Low levels of antidiuretic hormone. (c) ... the medullary interstitium in the kidneys. (d) Secretion of erythropoietin by Juxtaglomerular complex.
Last Answer : (c) Maintaining hyperosmolarity towards the medullary interstitium in the kidneys.
Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination
Last Answer : A. Have low oral bioavailability
Description : Renal glycosuria occurs due to (A) Increased filtration of glucose in glomeruli (B) Increased secretion of glucose by renal tubular cells (C) Decreased reabsorption of glucose by renal tubular cells (D) Increased conversion of glycogen into glucose in tubular cells
Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin
Last Answer : C. Lomefloxacin
Description : Choose the correct statement about topical NSAID preparations: A. They produce high drug levels in the blood by avoiding hepatic first pass metabolism B. They produce high drug levels in ... a strong placebo effect D. Interindividual variability in clinical response to these preparations is minimal
Last Answer : C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect
Description : Transdermal estradiol differs from oral estrogen therapy in that it: A. Causes less induction of hepatic synthesis of clotting factors B. Does not inhibit FSH secretion C. Does not affect vaginal cytology D. All of the above are correct
Last Answer : A. Causes less induction of hepatic synthesis of clotting factors
Description : Adrenaline raises blood glucose level by the following actions except: A. Inducing hepatic glycogenolysis B. Inhibiting insulin secretion from pancreatic β cells C. Augmenting glucagon secretion from pancreatic α cells D. Inhibiting peripheral glucose utilization
Last Answer : D. Inhibiting peripheral glucose utilization
Description : The third generation cephalosporins differ from the first generation cephalosporins in that they are: A. More active against gram positive cocci B. More active against gram negative enterobacteriaceae C. Nonimmunogenic D. Not excreted by tubular secretion
Last Answer : B. More active against gram negative enterobacteriaceae
Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Last Answer : D. Redistribution
Description : Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism
Last Answer : C. In equianalgesic doses it is safer than aspirin
Description : An important finding in glycinuria is (A) Excess excretion of oxalate in the urine (B) Deficiency of enzyme glycinase (C) Significantly increased serum glycine level (D) Defect in renal tubular reabsorption of glycine
Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated
Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally
Description : Assertion `:-` Tubular is of considerable importance in Marine teleost fishes. Reason `:-` These fishes have no glomerular kidney .
Last Answer : Assertion `:-` Tubular is of considerable importance in Marine teleost fishes. Reason `:-` These fishes ... D. If both Assertion & Reason are false.
Description : Which of the following statement(s) is/are true concerning the effects of MOFS? a. Pulmonary dysfunction tends to arise early and may resolve within 7 to 10 days b. Unless the precipitating ... infection, most commonly pulmonary, is a common complication providing a second hit to the patient
Last Answer : Answer: a, b, d Pulmonary dysfunction typically arises early in the development of systemic inflammation and may represent mild relatively localized acute lung injury or it may be a prelude ... is marked by progressive rise in serum bilirubin levels after a latent period of several days
Description : Among the following, a test of Glomerular function is (A) Urea clearance (B) PSP excretion test (C) PAH clearance (D) Hippuric acid excretion test
Description : Which one of the following statements in regard to the excretion by the human kidneys is correct? (a) Descending limb of loop of Henle is impermeable to water. (b) Distal convoluted tubule is ... reabsorbed by the renal tubules. (d) Ascending limb of loop of Henle is impermeable to electrolytes.
Last Answer : (c) Nearly 99 per cent of the glomerular filtrate is reabsorbed by the renal tubules.
Description : A fall in glomerular filtration rate (GFR) activates
Last Answer : A fall in glomerular filtration rate (GFR) activates A. adrenal medulla ot release adrenaline ... renin D. adrenal cortex to release aldosterone
Last Answer : A fall in glomerular filtration rate (GFR) activates A. Juxtaglomerular cells to release ... adrenaline D. Posterior pituitary to release vasopressin
Description : Glomerular filtration rate would be decreased by
Last Answer : Glomerular filtration rate would be decreased by A. An increase in the renal blood flow ... pressure D. Constriction of the efferent arteriole
Description : The glomerular filtration rate is
Last Answer : The glomerular filtration rate is A. 125 mL/min B. 180 L/day C. 1300 mL/min D. Both (1) and (2)
Description : Glomerular filtration rate?
Last Answer : DefinitionGlomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the tiny filters in the kidneys, called ... The blood collects into an airtight vial or tube attached to the needle. The elastic band is