Description : The following action of 5-Hydroxy tryptamine is mediated by the 5-HT3 receptor: A. Vasoconstriction B. Bradycardia C. EDRF release D. Platelet aggregation
Last Answer : B. Bradycardia
Description : A sympathomimetic amine that acts almost exclusively by releasing noradrenaline from the nerve endings is (a) Ephedrine (b) Dopamine (c) Isoprenaline (d) Tyramine
Last Answer : Ans: D
Description : A sympathomimetic amine that acts almost exclusively by releasing noradrenaline from the nerve endings is: A. Ephedrine B. Dopamine C. Isoprenaline D. Tyramine
Last Answer : D. Tyramine
Description : Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out ... host cells has low affinity for tetracyclines D. Both A' and C' are correct
Last Answer : D. Both ‘A’ and ‘C’ are correct
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : The following is true of bupropion except: A. It inhibits dopamine reuptake along with inhibiting noradrenaline reuptake B. It produces sedation as a side effect C. It is being used as an aid for smoking cessation D. It is likely to produce seizures in overdose
Last Answer : B. It produces sedation as a side effect
Description : The action of 5-Hydroxy tryptamine mediated by the 5-HT3 receptor is (a) Vasoconstriction (b) Bradycardia (c) EDRF release (d) Platelet aggregation
Last Answer : Ans: B
Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor
Last Answer : B. Serotonin
Description : True statements about the following neurotransmitters include: a. dopamine is formed from tyrosine b. in the synapse, noradrenaline is inactivated by active reuptake into the presynpatic terminals c. noradrenaline is formed by hydroxylation of dopamine d. all above
Last Answer : all above
Description : In carcinoid syndrome the argentaffin tissue of the abdominal cavity overproduce (A) Serotonin (B) Histamine (C) Tryptamine (D) Tyrosine
Last Answer : Answer : A
Description : Prazosin is an effective antihypertensive while nonselective α adrenergic blockers are not because: A. It is the only orally active α blocker B. It improves plasma lipid profile C. It does not concurrently enhance noradrenaline release D. It improves urine flow in males with prostatic hypertrophy
Last Answer : C. It does not concurrently enhance noradrenaline release
Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins
Last Answer : B. Anticholinergics
Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa
Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa
Description : The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently ... suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines
Last Answer : D. It does not block neuronal uptake of biogenic amines
Description : The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of ... of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries
Last Answer : A. Inhibition of levodopa methylation in the liver
Description : In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of ... with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect
Last Answer : D. It does not produce behavioral/psychiatric side effects
Description : Bacteria develop tetracycline resistance by the following mechanisms except: A. Losing tetracycline concentrating mechanisms B. Elaborating tetracycline inactivating enzyme C. Synthesizing a protection protein' ... the target site D. Actively pumping out tetracycline that has entered the cell
Last Answer : B. Elaborating tetracycline inactivating enzym
Description : The following are true about the neurotransmitters: a. acetylcholine is inactivated mainly by presynaptic reuptake b. tyrosine is essential for the formation of dopamine c. noradrenaline is inactivated mainly by hydrolysis d. adrenaline is formed from methylation of the noradrenaline
Last Answer : adrenaline is formed from methylation of the noradrenaline
Description : The following enzymes on the left are responsible for the synthesis of the neurotransmitters on the right: a. monoamine oxidase: noradrenaline b. cholinesterase: acetylcholine c. catechol-o-methyl transferase: dopamine d. dopa decarboxylase: adrenaline
Last Answer : dopa decarboxylase: adrenaline
Description : The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase
Last Answer : A. Tyrosine hydroxylase
Description : The following sympathomimetic amine has agonistic action on α1 + α2 + β1 + β3 adrenoceptors, but not on β2 receptors: A. Adrenaline B. Noradrenaline C. Isoprenaline D. Phenylephrine
Last Answer : B. Noradrenaline
Description : The following sympathomimetic amine has agonistic action on α 1 + α 2 + β 1 + β 3 adrenoceptors, but not on β 2 receptors: A. Adrenaline B. Noradrenaline C. Isoprenaline D. Phenylephrine
Description : Answer: b, c, d Eosinophils constitute 1% to 3% of the leukocyte population of the bloodstream. They also reside in tissues and they exhibit phagocytic capabilities. They are less ... the cycle of events that result in recruitment and activation of inflammatory cells at sites of inflammation
Last Answer : Cellular injury from oxidants may be manifest by which of the following? a. Cell membrane lipid peroxidation b. DNA strand breaks c. Cytoskeletal disassembly d. ATP depletion
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Description : Select the oral iron preparation which does not impart metallic taste and has good oral tolerability despite high iron content but whose efficacy in treating iron deficiency anaemia has been questioned: A. Iron hydroxy polymaltose B. Ferrous succinate C. Ferrous fumarate D. Ferrous gluconate
Last Answer : A. Iron hydroxy polymaltose
Description : Venlafaxine differs from standard tricyclic antidepressants in that it: A. Does not inhibit 5-HT reuptake B. Does not inhibit noradrenaline reuptake C. Does not have anticholinergic or antiadrenergic property D. Has lower antidepressant efficacy
Last Answer : C. Does not have anticholinergic or antiadrenergic property
Description : Adaptive changes in brain monoamine turnover due to blockade of noradrenaline/5-HT reuptake is credited with the following effect: A. Antipsychotic B. Antianxiety C. Antiparkinsonian D. Antidepressant
Last Answer : D. Antidepressant
Description : Metronidazole is selectively active against anaerobic organisms because: A. Aerobes have an active transport mechanism to pump it out of their cell B. Only anaerobes reduce it to generate the reactive ... inactivated in the presence of oxygen D. It binds to DNA of anaerobes with high affinity
Last Answer : B. Only anaerobes reduce it to generate the reactive nitro radical
Description : A patient has an episode of hematemesis following streptokinase infused for the treatment of deep vein thrombosis. Which of the following drugs would be most effective in controlling the bleeding episode: A. Vitamin K B. Noradrenaline C. Epsilon aminocaproic acid D. Rutin
Last Answer : C. Epsilon aminocaproic acid
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : Which of the following is labelled as a 'serotonin and noradrenaline reuptake inhibitor or SNRI': A. Amineptine B. Venlafaxine C. Bupropion D. Citalopram
Last Answer : D. Citalopram
Description : The mechanisms involved in the causation of dangerous cardiac arrhythmias due to overdose of tricyclic antidepressants include the following except: A. Intraventricular conduction block B. Potentiation of noradrenaline C. Antagonism of acetylcholine D. Increased vagal tone
Last Answer : D. Increased vagal tone
Description : The usual cardiovascular effect of levodopa is: A. Bradycardia due to increased vagal tone B. Rise in blood pressure due to increased noradrenaline content of adrenergic nerve endings C. Fall in blood pressure due to decrease in sympathetic tone D. Both ‘A’ and ‘B’ are correct
Last Answer : C. Fall in blood pressure due to decrease in sympathetic tone
Description : While undergoing a surgical procedure a patient deve- lops hypotension. Which drug can be injected intramuscularly to raise his BP: A. Noradrenaline B. Isoprenaline C. Mephentermine D. Isoxsuprine
Last Answer : C. Mephentermine
Description : Which pressor agent acts directly as well as indirectly and produces both vasoconstriction and cardiac stimulation: A. Phenylephrine B. Methoxamine C. Noradrenaline D. Mephentermine
Last Answer : D. Mephentermine
Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings
Last Answer : A. Direct vasodilatation
Description : While undergoing a surgical procedure a patient develops hypotension. Which drug can be injected intramuscularly to raise his BP: A. Noradrenaline B. Isoprenaline C. Mephentermine D. Isoxsuprine
Description : Vasomotor reversal phenomenon after administration of an α adrenergic blocker is seen with: A. Adrenaline B. Noradrenaline C. Isoprenaline D. All of the above drugs
Last Answer : A. Adrenaline
Description : The principal process which terminates the action of noradrenaline released from adrenergic nerve ending is: A. Degradation by MAO B. Methylation by COMT C. Axonal uptake D. Extraneuronal uptake
Last Answer : C. Axonal uptake
Description : The following type/types of noradrenaline uptake is blocked by reserpine: A. Axonal uptake B. Granular uptake C. Extraneuronal uptake D. All of the above
Last Answer : B. Granular uptake
Description : Tyramine induces release of noradrenaline from adrenergic nerve endings: A. By depolarizing the axonal membrane B. By mobilizing Ca2+ C. By a nonexocytotic process D. Only in the presence of MAO inhibitors
Last Answer : C. By a nonexocytotic process
Description : Cisapride enhances gastrointestinal motility by: A. Activating serotonin 5-HT4 receptor B. Activating muscarinic M3 receptor C. Blocking dopamine D2 receptor D. All of the above
Last Answer : A. Activating serotonin 5-HT4 receptor