The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of dopamine methylation in the brain C. Inhibition of oxidative deamination of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

The primary action by which entacapone and tolcapone
enhance the therapeutic effect of levodopa-carbidopa
in parkinsonism is:
A. Inhibition of levodopa methylation in the
liver
B. Inhibition of dopamine methylation in the
brain
C. Inhibition of oxidative deamination of
dopamine in the brain
D. Facilitation of active transport of levodopa
across brain capillaries
by

1 Answer

Answer :

A. Inhibition of levodopa methylation in the
liver
by

Related questions

The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec

Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec

Last Answer : A. It acts by inhibiting degradation of dopamine in the brain

Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. Used alone, its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

Last Answer : C. Used alone, its effective doses produce intolerable side effect

In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of action C. It activates dopamine D2 receptors, with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

Description : In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of ... with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

Last Answer : D. It does not produce behavioral/psychiatric side effects

Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct

Description : Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct

Last Answer : D. All of the above are correct

Use of carbidopa along with levodopa in the treatment of parkinsonism: A. Inhibits development of involuntary movements B. Minimises ‘on-off ’ effect’ C. Inhibits occurrence of behavioral abnormalities D. Accentuates nausea and vomiting

Description : Use of carbidopa along with levodopa in the treatment of parkinsonism: A. Inhibits development of involuntary movements B. Minimises ‘on-off ’ effect’ C. Inhibits occurrence of behavioral abnormalities D. Accentuates nausea and vomiting

Last Answer : B. Minimises ‘on-off ’ effect

For majority of patients of parkinsonism the standard drug therapy is: A. Levodopa B. Levodopa + carbidopa C. Levodopa + trihexiphenidyl D. Bromocriptine

Description : For majority of patients of parkinsonism the standard drug therapy is: A. Levodopa B. Levodopa + carbidopa C. Levodopa + trihexiphenidyl D. Bromocriptine

Last Answer : B. Levodopa + carbidopa

The following drug is effective in chlorpromazine induced parkinsonism: A. Trihexyphenidyl B. Selegiline C. Bromocriptine D. Levodopa + carbidopa

Description : The following drug is effective in chlorpromazine induced parkinsonism: A. Trihexyphenidyl B. Selegiline C. Bromocriptine D. Levodopa + carbidopa

Last Answer : A. Trihexyphenidyl

The most effective drug in parkinsonism is: A. Bromocriptine B. Selegiline C. Levodopa + carbidopa D. Biperiden

Description : The most effective drug in parkinsonism is: A. Bromocriptine B. Selegiline C. Levodopa + carbidopa D. Biperiden

Last Answer : C. Levodopa + carbidopa

Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue

Description : Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue

Last Answer : . Facilitation of neoglucogenesis by liver

The drug which abolishes the therapeutic effect of levodopa in parkinsonism, but not that of levodopacarbidopa combination is: A. Metoclopramide B. Pyridoxine C. Chlorpromazine D. Isoniazid

Description : The drug which abolishes the therapeutic effect of levodopa in parkinsonism, but not that of levodopacarbidopa combination is: A. Metoclopramide B. Pyridoxine C. Chlorpromazine D. Isoniazid

Last Answer : B. Pyridoxine

Ropinirole differs from bromocriptine in the following respect: A. It does not directly activate dopamine D2 receptors B. It produces milder gastrointestinal side effects C. In early cases of parkinsonism, it is less likely to need levodopa supplementation D. Both 'B' and 'C' are correct

Description : Ropinirole differs from bromocriptine in the following respect: A. It does not directly activate dopamine D2 receptors B. It produces milder gastrointestinal side effects C. In early cases of parkinsonism, it is less likely to need levodopa supplementation D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

Description : The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

Last Answer : D. Facilitation of GABA-mediated chloride influx

The following is true of selegiline: A. It does not exert antiparkinsonian action unless combined with levodopa B. It overcomes the ‘on-off ’ effect in levodopa treated advanced parkinsonian patients C. It retards the progression of Parkinson's disease D. At doses used in parkinsonism it does not interfere with peripheral metabolism of dietary amines

Description : The following is true of selegiline: A. It does not exert antiparkinsonian action unless combined with levodopa B. It overcomes the on-off ' effect in levodopa treated advanced parkinsonian ... D. At doses used in parkinsonism it does not interfere with peripheral metabolism of dietary amines

Last Answer : . At doses used in parkinsonism it does not interfere with peripheral metabolism of dietary amines

Tolerance to the antiparkinsonian action develops most rapidly in the case of: A. Levodopa B. Levodopa + carbidopa C. Amantadine D. Bromocriptine

Description : Tolerance to the antiparkinsonian action develops most rapidly in the case of: A. Levodopa B. Levodopa + carbidopa C. Amantadine D. Bromocriptine

Last Answer : C. Amantadine

The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is: A. Carbidopa B. Amantadine C. Selegiline D. Bromocriptine

Description : The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is: A. Carbidopa B. Amantadine C. Selegiline D. Bromocriptine

Last Answer : C. Selegiline

The following adverse effect of levodopa is not minimised by combining it with carbidopa: A. Involuntary movements B. Nausea and vomiting C. Cardiac arrhythmia D. ‘On-off ’ effect

Description : The following adverse effect of levodopa is not minimised by combining it with carbidopa: A. Involuntary movements B. Nausea and vomiting C. Cardiac arrhythmia D. ‘On-off ’ effect

Last Answer : A. Involuntary movements

The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case

Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case

Last Answer : D. They are the preferred drugs in advanced cases

The following drug is added to levodopa therapy of parkinsonism to attenuate ‘wearing off’ effect: A. Selegiline B. Trihexiphenidyl C. Amantadine D. Any of the abov

Description : The following drug is added to levodopa therapy of parkinsonism to attenuate ‘wearing off’ effect: A. Selegiline B. Trihexiphenidyl C. Amantadine D. Any of the abov

Last Answer : A. Selegiline

he primary mechanism by which heparin prevents coagulation of blood is: A. Direct inhibition of prothrombin to thrombin conversion B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin C. Activation of antithrombin III to inhibit factors IX and XI D. Inhibition of factors XIIa and XIIIa

Description : he primary mechanism by which heparin prevents coagulation of blood is: A. Direct inhibition of prothrombin to thrombin conversion B. Facilitation of antithrombin III mediated inhibition of factor Xa and ... of antithrombin III to inhibit factors IX and XI D. Inhibition of factors XIIa and XIIIa

Last Answer : B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombi

The following action(s) of heparin is/are essential for inhibition of factor Xa: A. Facilitation of antithrombin III mediated inhibition of factor XIIa B. Provision of scaffold for the clotting factor to interact with antithrombin III C. Induction of a configurational change in antithrombin III to expose its interacting sites D. Both ‘A’ and ‘B

Description : The following action(s) of heparin is/are essential for inhibition of factor Xa: A. Facilitation of antithrombin III mediated inhibition of factor XIIa B. Provision of scaffold for the clotting factor ... configurational change in antithrombin III to expose its interacting sites D. Both A' and B

Last Answer : C. Induction of a configurational change in antithrombin III to expose its interacting sites

The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above

Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above

Last Answer : B. Levodopa

The following drug combination should not be used in parkinsonism: A. Levodopa + anticholinergics B. Levodopa + amantadine C. Bromocriptine + levodopa D. Amantadine + anticholinergics

Description : The following drug combination should not be used in parkinsonism: A. Levodopa + anticholinergics B. Levodopa + amantadine C. Bromocriptine + levodopa D. Amantadine + anticholinergics

Last Answer : D. Amantadine + anticholinergics

Bactericidal action of aminoglycoside antibiotics is due to: A. Inhibition of bacterial protein synthesis B. Alteration of bacterial cell membrane permeability C. Damage to bacterial cell wall D. Inhibition of bacterial oxidative metabolism

Description : Bactericidal action of aminoglycoside antibiotics is due to: A. Inhibition of bacterial protein synthesis B. Alteration of bacterial cell membrane permeability C. Damage to bacterial cell wall D. Inhibition of bacterial oxidative metabolism

Last Answer : B. Alteration of bacterial cell membrane permeability

Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secretion B. Cyclic AMP enhances but cyclic GMP inhibits Cl– and HCO3 – secretion C. Cyclic AMP inhibits but cyclic GMP enhances Na+ and Cl– reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl– reabsorption

Description : Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 - secretion B. Cyclic AMP enhances but cyclic GMP ... Cl- reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl- reabsorption

Last Answer : A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secreti

The main sites for oxidative deamination are (A) Liver and kidney (B) Skin and pancreas (C) Intestine and mammary gland (D) Lung and spleen

Description : The main sites for oxidative deamination are (A) Liver and kidney (B) Skin and pancreas (C) Intestine and mammary gland (D) Lung and spleen

Last Answer : Answer : A

d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination

Description : d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination

Last Answer : Answer : A

Both folic acid and methyl cobalamin (vitamin B12) are required in (A) Deamination of serine (B) Deamination of threonine (C) Conversion of pyridoxal phosphate to pyridoxamine phosphate (D) Methylation of homocystein to methionine

Description : Both folic acid and methyl cobalamin (vitamin B12) are required in (A) Deamination of serine (B) Deamination of threonine (C) Conversion of pyridoxal phosphate to pyridoxamine phosphate (D) Methylation of homocystein to methionine

Last Answer : Answer : D

The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Description : The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells C. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Last Answer : D. All of the above

Phenytoin appears to derive its anticonvulsant action from: A. Selective inhibition of high frequency neuronal discharges B. Selective inhibition of epileptic focus C. Selective inhibition T-type Ca2+ current in brain cells D. Selective enhancement of inhibitory transmission in the brain

Description : Phenytoin appears to derive its anticonvulsant action from: A. Selective inhibition of high frequency neuronal discharges B. Selective inhibition of epileptic focus C. Selective inhibition T-type Ca2+ current in brain cells D. Selective enhancement of inhibitory transmission in the brain

Last Answer : A. Selective inhibition of high frequency neuronal discharges

The antidotal effect of sodium nitrite in cyanide poisoning is dependent upon: A. Chemical combination of sodium nitrite with cyanide B. Vasodilatation caused by sodium nitrite C. Conversion of haemoglobin to methaemoglobin by sodium nitrite D. Facilitation of cyanocobalamine formation by sodium nitrite

Description : The antidotal effect of sodium nitrite in cyanide poisoning is dependent upon: A. Chemical combination of sodium nitrite with cyanide B. Vasodilatation caused by sodium nitrite C. ... haemoglobin to methaemoglobin by sodium nitrite D. Facilitation of cyanocobalamine formation by sodium nitrite

Last Answer : C. Conversion of haemoglobin to methaemoglobin by sodium nitrite

The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug

Description : The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in ... locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug

Last Answer : B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally

The site of action of miotics for therapeutic effect in angle closure glaucoma is: A. Canal of Schlemm B. Ciliary body C. Ciliary muscle D. Sphincter pupillae muscle

Description : The site of action of miotics for therapeutic effect in angle closure glaucoma is: A. Canal of Schlemm B. Ciliary body C. Ciliary muscle D. Sphincter pupillae muscle

Last Answer : D. Sphincter pupillae muscle

When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

Last Answer : C. Therapeutic window phenomenon

The principal process which terminates the action of noradrenaline released from adrenergic nerve ending is: A. Degradation by MAO B. Methylation by COMT C. Axonal uptake D. Extraneuronal uptake

Description : The principal process which terminates the action of noradrenaline released from adrenergic nerve ending is: A. Degradation by MAO B. Methylation by COMT C. Axonal uptake D. Extraneuronal uptake

Last Answer : C. Axonal uptake

Pyruvate is converted into acetyl-CoA by (A) Decarboxylation (B) Dehydrogenation (C) Oxidative decarboxylation (D) Oxidative deamination

Description : Pyruvate is converted into acetyl-CoA by (A) Decarboxylation (B) Dehydrogenation (C) Oxidative decarboxylation (D) Oxidative deamination

Last Answer : Answer : C

Histidine is converted to histamine through the process of (A) Transamination (B) Decarboxylation (C) Oxidative deamination (D) Urea cycle

Description : Histidine is converted to histamine through the process of (A) Transamination (B) Decarboxylation (C) Oxidative deamination (D) Urea cycle

Last Answer : Answer : B

Free ammonia is released during (A) Oxidative deamination of glutamate (B) Catabolism of purines (C) Catabolism of pyrimidines (D) All of these

Description : Free ammonia is released during (A) Oxidative deamination of glutamate (B) Catabolism of purines (C) Catabolism of pyrimidines (D) All of these

Last Answer : Answer : D

The amino acid that undergoes oxidative deamination at significant rate is (A) Alanine (B) Aspartate (C) Glutamate (D) Glutamine

Description : The amino acid that undergoes oxidative deamination at significant rate is (A) Alanine (B) Aspartate (C) Glutamate (D) Glutamine

Last Answer : Answer : C

The following effect(s) of tamoxifen citrate indicate(s) that it possesses tissue specific estrogenic action as well: A. Inhibition of breast cancer cells B. Endometrial proliferation C. Hot flushes in premenopausal women D. All of the above

Description : The following effect(s) of tamoxifen citrate indicate(s) that it possesses tissue specific estrogenic action as well: A. Inhibition of breast cancer cells B. Endometrial proliferation C. Hot flushes in premenopausal women D. All of the above

Last Answer : B. Endometrial proliferation

The extrapyramidal adverse effect of antipsychotic drug therapy which does not respond to central anticholinergics is: A. Parkinsonism B. Acute muscle dystonia C. Rabbit syndrome D. Tardive dyskinesia

Description : The extrapyramidal adverse effect of antipsychotic drug therapy which does not respond to central anticholinergics is: A. Parkinsonism B. Acute muscle dystonia C. Rabbit syndrome D. Tardive dyskinesia

Last Answer : D. Tardive dyskinesia

The following side effect of typical neuroleptics may respond to propranolol: A. Parkinsonism B. Acute muscle dystonia C. Tardive dyskinesia D. Akathisia (p. 397) 30.15 3 0 . 1 5 B 30.16 3 0 . 1 6 D

Description : The following side effect of typical neuroleptics may respond to propranolol: A. Parkinsonism B. Acute muscle dystonia C. Tardive dyskinesia D. Akathisia (p. 397) 30.15 3 0 . 1 5 B 30.16 3 0 . 1 6 D

Last Answer : D. Akathisia (p. 397)

Which antiemetic selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action: A. Metoclopramide B. Cisapride C. Domperidone D. Ondansetron

Description : Which antiemetic selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action: A. Metoclopramide B. Cisapride C. Domperidone D. Ondansetron

Last Answer : C. Domperidone

Which of the following drugs has mild antiparkinsonian action of its own, prolongs levodopa action and allows reduction of its dose by about 25%: A. Benserazide B. Selegiline C. Amantadine D. Pyridoxine

Description : Which of the following drugs has mild antiparkinsonian action of its own, prolongs levodopa action and allows reduction of its dose by about 25%: A. Benserazide B. Selegiline C. Amantadine D. Pyridoxine

Last Answer : B. Selegiline

Tolerance is generally not acquired to: A. Antisecretory action of atropine B. Sedative action of chlorpromazine C. Emetic action of levodopa D. Vasodilator action of nitrates

Description : Tolerance is generally not acquired to: A. Antisecretory action of atropine B. Sedative action of chlorpromazine C. Emetic action of levodopa D. Vasodilator action of nitrates

Last Answer : A. Antisecretory action of atropine

The following are true about the neurotransmitters: a. acetylcholine is inactivated mainly by presynaptic reuptake b. tyrosine is essential for the formation of dopamine c. noradrenaline is inactivated mainly by hydrolysis d. adrenaline is formed from methylation of the noradrenaline

Description : The following are true about the neurotransmitters: a. acetylcholine is inactivated mainly by presynaptic reuptake b. tyrosine is essential for the formation of dopamine c. noradrenaline is inactivated mainly by hydrolysis d. adrenaline is formed from methylation of the noradrenaline

Last Answer : adrenaline is formed from methylation of the noradrenaline

The following biogenic amine is not actively taken up into its storage site by an active amine pump: A. Histamine B. 5-Hydroxy tryptamine C. Dopamine D. Noradrenaline

Description : The following biogenic amine is not actively taken up into its storage site by an active amine pump: A. Histamine B. 5-Hydroxy tryptamine C. Dopamine D. Noradrenaline

Last Answer : A. Histamine

he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma

Description : he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma

Last Answer : D. Glaucoma

Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood