What is the function of Fibrinogen in blood? -Biology

What is the function of Fibrinogen in blood? -Biology
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Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning coagulation tests? a. Prothrombin time (PT) measures both the intrinsic and extrinsic clotting pathways and fibrinogen b. Activated partial thromboplastin time (aPTT) can be used to monitor both oral anticoagulation with Warfarin and intravenous anticoagulation with heparin c. Thrombin clotting time (TCT) is a measurement of the time it takes for exogenously administered thrombin to turn plasma fibrinogen into fibrin clot d. Whole blood activated clotting time (ACT) is a measurement of the ability of whole blood to clot and is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascu

Description : Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning ... is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascular operations

Last Answer : Answer: a, c, d Coagulation tests include prothrombin time (PT), which measures the intrinsic and extrinsic pathways of fibrinogen production and is the most common method for ... more while for peripheral vascular applications, values of 250 seconds or greater are considered appropriate

Blood does not clot in the blood vessels due to the presence of – (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Description : Blood does not clot in the blood vessels due to the presence of – (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : (3) Heparin Explanation: There are two major facets of the clotting mechanism — the platelets, and the thrombin system. The thrombin system consists of several blood proteins that, when bleeding occurs, become activated.

Which is the anticoagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Description : Which is the anticoagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Last Answer : (2) Heparin Explanation: Heparin, a highly sulfated glycosaminoglycan, is widely used as an inject able anticoagulant, and has the highest negative charge density of any known ... because blood anti-coagulation is achieved mostly by heparin sulfate proteoglyeans derived from endothelial cells.

The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn blood delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Description : The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn ... delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Last Answer : thrombin converts fibrinogen to fibrin

Which one of the following is correct? (a) Lymph = Plasma + RBC + WBC (b) Blood = Plasma + RBC + WBC + Platelets (c) Plasma = Blood – Lymphocytes (d) Serum = Blood + Fibrinogen

Description : Which one of the following is correct? (a) Lymph = Plasma + RBC + WBC (b) Blood = Plasma + RBC + WBC + Platelets (c) Plasma = Blood – Lymphocytes (d) Serum = Blood + Fibrinogen

Last Answer : (b) Blood = Plasma + RBC + WBC + Platelets

Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Fibrinogen (i) Osmotic balance B. Globulin (ii) Blood clotting C. Albumin (iii)Defence mechanism A B C (a) (iii) (ii) (i) (b) (i) (ii) (iii) (c) (i) (iii) (ii) (d) (ii) (iii) (i)

Description : Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Fibrinogen (i) Osmotic balance B. Globulin (ii) Blood clotting C. Albumin (iii)Defence mechanism A B C (a) ( ... i) (b) (i) (ii) (iii) (c) (i) (iii) (ii) (d) (ii) (iii) (i)

Last Answer : (d) (ii) (iii) (i)

Which of the following is not found in blood? a) fibrinogen b) glucose c) urea d) glycogen

Description : Which of the following is not found in blood? a) fibrinogen b) glucose c) urea d) glycogen

Last Answer : ANSWER: D -- GLYCOGEN

Blood does not clot in the blood vessels due to the presence of (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Description : Blood does not clot in the blood vessels due to the presence of (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : Thrombin

Which is the anti-coagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Description : Which is the anti-coagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Last Answer : Heparin

Prothrombin , albumin and fibrinogen are synthesised by

Description : Prothrombin , albumin and fibrinogen are synthesised by

Last Answer : Prothrombin , albumin and fibrinogen are synthesised by A. Pancreas B. Bone marrow C. Spleen D. Liver

The following statement(s) is/are true concerning host defense mechanisms to intraabdominal infection. a. Bacterial clearance can occur via translymphatic absorption b. Phagocytic activity and bacterial killing can occur via resident phagocytic cells and an influx of PMNs c. A fibrinogen-rich inflammatory exudate is released into the peritoneal cavity, trapping large numbers of bacteria and other particulate matter d. Perforations of a bowel may be walled off but are seldom sealed by the omentum and other mobile viscera

Description : The following statement(s) is/are true concerning host defense mechanisms to intraabdominal infection. a. Bacterial clearance can occur via translymphatic absorption b. Phagocytic activity and bacterial killing can ... may be walled off but are seldom sealed by the omentum and other mobile viscera

Last Answer : Answer: a, b, c The introduction of microorganisms into the normally sterile peritoneal environment invoke several potent specialized host antimicrobial defense mechanisms. Bacterial clearance, ... the contaminated enteric contents walled off, preventing continued soilage of the peritoneal cavity

Answer: a, b, c, d Free oxygen radicals are chemical species that are intermediates in the normal process of cellular respiration. Oxidants that are free radicals have been implicated as initiators of reactions which lead to a variety of cellular injuries. Oxidants are derived from several sources, notably phagocytes. Among the effects of oxygen free radicals are membrane lipid peroxidation, DNA strand breaks, cytoskeletal disassembly and inhibition of glucose metabolism leading to decreased cellular ATP concentrations. (Figure 6-16) 187 Which of the following acute-phase protein levels are increased in human plasma following acute inflammation? a. C-reactive protein b. Serum amyloid c. a -Proteinase inhibitor d. Fibrinogen e. Albumin

Description : Answer: a, b, c, d Free oxygen radicals are chemical species that are intermediates in the normal process of cellular respiration. Oxidants that are free radicals have been implicated as initiators of ... a. C-reactive protein b. Serum amyloid c. a -Proteinase inhibitor d. Fibrinogen e. Albumin

Last Answer : Answer: a, b, c, d The acute-phase response is a series of homeostatic responses of the organism to tissue injury in infection and inflammation. After an inflammatory stimulus occurs, a number ... 30% to 50% of the level before injury. The reason for the decrease in production is poorly understood

Bleeding complications are frequently associated with fibrinolytic therapy. Which of the following statement(s) concerning complications of fibrinolytic therapy is/are true? a. Careful monitoring of prothrombin time and aPTT time are necessary to avoid bleeding complications b. A level of serum fibrinogen less than 100 mg/dl is associated with an increased risk of bleeding c. Recent (less than 10 days) major surgery is a contraindication to systemic but not regional fibrinolytic therapy d. A patient with a cerebrovascular event occurring less than two months ago can be treated with fibrinolytic therapy if head CT scan is normal

Description : Bleeding complications are frequently associated with fibrinolytic therapy. Which of the following statement(s) concerning complications of fibrinolytic therapy is/are true? a. Careful monitoring of prothrombin time ... months ago can be treated with fibrinolytic therapy if head CT scan is normal

Last Answer : Answer: b Fibrinolytic therapy induces a hemostatic defect through a combination of factors. Hypofibrinogenemia and fibrin degradation products inhibit fibrin polymerization and, in combination ... is considered a major relative contraindication to either regional or systemic thrombolytic therapy

A 67-year-old male with advanced cholangiocarcinoma develops gram-negative sepsis. Excessive bleeding is noted around vascular catheters and from needle puncture sites. The diagnosis of disseminated intervascular coagulation (DIC) is considered. Which of the following laboratory test(s) is/are indicative of DIC? a. Decreased platelet count b. Decreased fibrinogen level c. Normal prothrombin time d. Elevated fibrin split products

Description : A 67-year-old male with advanced cholangiocarcinoma develops gram-negative sepsis. Excessive bleeding is noted around vascular catheters and from needle puncture sites. The diagnosis of disseminated ... b. Decreased fibrinogen level c. Normal prothrombin time d. Elevated fibrin split products

Last Answer : Answer: a, b, d Disseminated intravascular coagulation (DIC) is the primary form of acute thrombosis. Causes of this syndrome include abruptio placenta, gram-positive and gram-negative sepsis, ... decline in the platelet count and fibrinogen level, along with an elevation of fibrin split products

Interleukin-6 is recognized as the cytokine primarily responsible for the alteration in hepatic protein synthesis recognized as the acute phase response. Which of the following statement(s) is/are true concerning acute phase protein response to surgical stress? a. Glucocorticoid hormones inhibit this response b. Proteins such as albumin and transferrin which serve in serum transport are generally increased in this response c. Examples of acute phase proteins include fibrinogen and C-reactive protein d. In general, the physiologic role of acute phase proteins are to reduce the systemic effects of tissue damage

Description : Interleukin-6 is recognized as the cytokine primarily responsible for the alteration in hepatic protein synthesis recognized as the acute phase response. Which of the following statement(s) is/are true ... physiologic role of acute phase proteins are to reduce the systemic effects of tissue damage

Last Answer : Answer: c, d IL-6 is now recognized at the cytokine primarily responsible for the alteration in hepatic synthesis recognized as the acute phase response. Glucocorticoid hormones augment ... that generally inhibit the tissue destruction that is associated with the local initiation of inflammation

Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and formation of a hemostatic plug. B. Interaction of tissue factor with factor VII circulating in the plasma. C. The production of thrombin via the coagulation cascade with conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot

If you suspect major deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence? (a) Haemocytes (b) Serum globulins (c) Fibrinogen in plasma (d) Serum albumins

Description : If you suspect major deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence? (a) Haemocytes (b) Serum globulins (c) Fibrinogen in plasma (d) Serum albumins

Last Answer : (b) Serum globulins

Vitamin K is required for (a) change of prothrombin into thrombin (b) synthesis of prothrombin (c) change of fibrinogen to fibrin (d) formation of thromboplastin.

Description : Vitamin K is required for (a) change of prothrombin into thrombin (b) synthesis of prothrombin (c) change of fibrinogen to fibrin (d) formation of thromboplastin.

Last Answer : (b) synthesis of prothrombin

The most abundant protein in the body is Options: 1) Albumin 2) Globulin 3) Collagen 4) Fibrinogen

Description : The most abundant protein in the body is Options: 1) Albumin 2) Globulin 3) Collagen 4) Fibrinogen

Last Answer : Correct Answer: 3) Collagen

Platelets play an important role in haemostasis; which of the following describes this role? A. They convert fibrinogen to fibrin B. They agglutinate and plug small, ruptured vessels C. They initiate fibrinolysis in thrombosis D. They supply fibrin stabilizing factors E. They supply proconvertin for thromboplastin activation

Description : Platelets play an important role in haemostasis; which of the following describes this role? A. They convert fibrinogen to fibrin B. They agglutinate and plug small, ruptured ... thrombosis D. They supply fibrin stabilizing factors E. They supply proconvertin for thromboplastin activation

Last Answer : B. They agglutinate and plug small, ruptured vessels

The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level

Description : The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level

Last Answer : C. It increases the incidence of myopathy due to statins

The following is true of clopidogrel except: A. It is a GPIIb/IIIa receptor antagonist B. It inhibits fibrinogen induced platelet aggregation C. It is indicated for prevention of stroke in patients with transient ischaemic attacks D. It is a prodrug

Description : The following is true of clopidogrel except: A. It is a GPIIb/IIIa receptor antagonist B. It inhibits fibrinogen induced platelet aggregation C. It is indicated for prevention of stroke in patients with transient ischaemic attacks D. It is a prodrug

Last Answer : A. It is a GPIIb/IIIa receptor antagonist

Following is not the clotting factor ___________ a. Fibrinogen b. Prothrombin c. Hageman factor d. Ferritin

Description : Following is not the clotting factor ___________ a. Fibrinogen b. Prothrombin c. Hageman factor d. Ferritin

Last Answer : d. Ferritin

Sickle cell disease is inherited due to defective copies of _________gene. a. Heparin b. Haemoglobin c. Creatinine d. Fibrinogen

Description : Sickle cell disease is inherited due to defective copies of _________gene. a. Heparin b. Haemoglobin c. Creatinine d. Fibrinogen

Last Answer : b. Haemoglobin

Vitamin B2 is associated with formation of (a) Actomyosin (b) FMN & FAD (c) Fibrinogen (d) Acetylcholine

Description : Vitamin B2 is associated with formation of (a) Actomyosin (b) FMN & FAD (c) Fibrinogen (d) Acetylcholine

Last Answer : (b) FMN & FAD