The following is true of clopidogrel except:
A. It is a GPIIb/IIIa receptor antagonist
B. It inhibits fibrinogen induced platelet
aggregation
C. It is indicated for prevention of stroke in
patients with transient ischaemic attacks
D. It is a prodrug

1 Answer

Answer :

A. It is a GPIIb/IIIa receptor antagonist

Related questions

Description : The following is true of abciximab except: A. It is a monoclonal antibody against GPIIb/IIIa B. It inhibits platelet aggregation induced by a variety of platelet agonists C. It is antigenic D. It is used to reduce the risk of restenosis in patients undergoing PTCA

Last Answer : C. It is antigenic

Description : Indications for the use of antiplatelet drugs include the following except: A. Secondary prophylaxis of myocardial infarction B. Unstable angina pectoris C. Disseminated intravascular coagulation D. Stroke prevention in patients with transient ischaemic attacks

Last Answer : C. Disseminated intravascular coagulation

Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition

Description : Ticlopidine is recommended for the following except: A. To reduce neurological sequelae of stroke B. Transient ischaemic attacks C. To prevent occlusion of coronary artery bypass graft D. Intermittent claudication

Last Answer : A. To reduce neurological sequelae of stroke

Description : Low dose subcutaneous heparin therapy is indicated for: A. Prevention of leg vein thrombosis in elderly patients undergoing abdominal surgery B. Ischaemic stroke C. Patients undergoing neurosurgery D. Prevention of extention of coronary artery thrombus in acute myocardial infarction

Last Answer : A. Prevention of leg vein thrombosis in eld

Description : Select the correct statement about ethamsylate: A. It checks capillary bleeding B. It inhibits platelet aggregation C. It is an antifibrinolytic drug D. It is used to fibrose bleeding piles

Last Answer : ut ethamsylate: A

Description : The following action of 5-Hydroxy tryptamine is mediated by the 5-HT3 receptor: A. Vasoconstriction B. Bradycardia C. EDRF release D. Platelet aggregation

Last Answer : B. Bradycardia

Description : The following is true of anti-H.pylori therapy except: A. It is indicated in all patients of peptic ulcer B. Resistance to any single antimicrobial drug develops rapidly C. Concurrent ... efficacy of the regimen D. Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability

Last Answer : A. It is indicated in all patients of peptic ulcer

Description : The most effective drug for prevention of stroke in atrial fibrillation patients is: A. Aspirin B. Warfarin C. Low dose subcutaneous heparin D. Digoxin

Last Answer : B. Warfarin

Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation

Description : Choose the correct statement about bambuterol: A. It is an orally acting bronchodilator B. It is a prodrug C. It inhibits the enzyme pseudocholinesterase D. All of the above

Last Answer : D. All of the above

Description : Anticoagulant medication is indicated in: A. Immobilized elederly patients B. Buerger’s disease C. Stroke due to cerebral thrombosis D. All of the above

Last Answer : A. Immobilized elederly patients

Description : Laboratory monitoring of coagulation and anticoagulation includes testing of platelet function. Which of the following statements is/are true concerning tests of platelet function? a. A ... platelet aggregation should be part of the standard preoperative evaluation of patients using aspirin

Last Answer : Answer: a, c Tests of platelet function include peripheral platelet counts, bleeding times, and platelet aggregation. Usually, a platelet count of 50,000/mL or more ensures adequate hemostasis ... is not available in most laboratories, probably because of the observer-dependent nature of the test

Description : Which of the following statement(s) is/are true concerning hemophilia A? a. Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII b. A positive family history for ... platelet aggregation d. Spontaneous bleeding is unusual with factor VIII levels greater than 10% of normal

Last Answer : Answer: a, d Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII although 0% of cases are secondary to spontaneous mutation. The incidence of this abnormality is ... factor levels as low as 1% have been noted and patients are at risk for spontaneous bleeding

Description : Which of the following statement(s) is/are true concerning heparin-associated thrombocytopenia? a. Heparin-associated thrombocytopenia occurs only in the face of over anticoagulation with heparin b. ... d. Heparin-associated thrombocytopenia may be seen within hours of initiation of heparin therapy

Last Answer : Answer: b, c Heparin-associated thrombocytopenia occurs in 0.6% to 30% of patients who receive heparin, although severe thrombocytopenia (platelet counts less than 100,000) is seen in ... as coating on pulmonary artery catheters or low rate infusion into arterial catheters may cause this syndrome

Description : The action of 5-Hydroxy tryptamine mediated by the 5-HT3 receptor is (a) Vasoconstriction (b) Bradycardia (c) EDRF release (d) Platelet aggregation

Last Answer : Ans: B

Description : The following is true of mannitol except: A. It inhibits solute reabsorption in the thick ascending limb of loop of Henle B. It is contraindicated in patients with increased intracranial tension C. It ... acute left ventricular failure D. It is not used to treat cardiac or hepatic or renal edema

Last Answer : B. It is contraindicated in patients with increased intracranial tension

Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin

Last Answer : B. Ticlopidine

Description : Ergometrine stops postpartum haemorrhage by: A. Causing vasoconstriction of uterine arteries B. Increasing tone of uterine muscle C. Promoting coagulation D. Inducing platelet aggregation

Last Answer : B. Increasing tone of uterine muscle

Description : The following calcium channel blocker should not be used in patients with ischaemic heart disease: A. Verapamil sustained release tablet B. Amlodipine tablet C. Nifedipine soft geletin capsule D. Nifedipine extended release tablet

Last Answer : C. Nifedipine soft geletin capsule

Description : Use of morphine in the following category of patients does not carry any special risk: A. Ischaemic heart disease patients B. Bronchial asthma patients C. Elderly male patients D. Biliary colic patients

Last Answer : A. Ischaemic heart disease patients

Description : Radioactive iodine is the treatment of choice for the following category of thyrotoxic patients: A. Children B. Young adults with recent oneset of Grave’s disease C. Elderly patients with ischaemic heart disease D. Pregnant women

Last Answer : C. Elderly patients with ischaemic heart disease

Description : Thrombolytic therapy is indicated in the following conditions except: A. Acute myocardial infarction B. Stroke due to cerebral thrombosis C. Deep vein thrombosis D. Large pulmonary embolism

Last Answer : B. Stroke due to cerebral thrombosis

Description : Which of the following statements regarding cytokines is incorrect? A. Cytokines act directly on target cells and may potentiate the actions of one another. B. Interleukin 1 (IL-1) ... organ dysfunction syndrome because of its multiple actions and the secondary cascades that it stimulates.

Last Answer : Answer: C DISCUSSION: Cytokines are soluble peptide molecules that are synthesized and secreted by a number of cell types in response to injury, inflammation, and infection. Cytokines, which ... is thought to play a central role in the stress response, particularly in response to endotoxemia

Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab

Last Answer : C. Dipyridamole

Description : All of the following are true regarding platelet-activating factor (PAF) EXCEPT: C A. Induces platelet aggregation B. Stimulates platelet secretion C. It is a preformed molecule present in various cells D. None of these

Last Answer : It is a preformed molecule present in various cells

Description : Which of the following statements about septic shock are true? A. A circulating myocardial depressant factor may account for the cardiac dysfunction sometimes seen with shock due to sepsis or ... animal studies that demonstrate a significant improvement in survival with the use of such agents.

Last Answer : Answer: AB DISCUSSION: Shock due to sepsis or SIRS frequently manifests as a hyperdynamic cardiovascular response, consisting of an elevated CI and a decreased SVR or SVRI. Occasionally, ... been encouraging thus far in human clinical trials, despite the promising results from many animal studies

Description : In parkinsonian patients levodopa exerts the following effects except: A. Reduces skeletal muscle contractility B. Decreases muscle tone C. Increases locomotor activity D. Inhibits muscle tremor

Last Answer : A. Reduces skeletal muscle contractility

Description : The following is true of cyclophosphamide except: A. It is highly reactive and a vesicant on contact B. It is a prodrug C. It has marked immunosuppressant property D. It frequently causes alopecia and cystitis

Last Answer : A. It is highly reactive and a vesicant on contac

Description : Which of the following is a modifiable risk factor for transient ischemic attacks and ischemic strokes? a) History of smoking. Modifiable risk factors for TIAs and ischemic stroke include hypertension, Type ... ) Advanced age Advanced age, gender, and race are non-modifiable risk factors for stroke.

Last Answer : a) History of smoking. Modifiable risk factors for TIAs and ischemic stroke include hypertension, Type 1 diabetes, cardiac disease, history of smoking, and chronic alcoholism.

Description : Choose the correct statement about ondansetron: A. It is a dopamine D2 receptor antagonist B. It suppresses postoperative nausea and vomiting C. It is the most effective antiemetic for motion sickness D. It is not effective by oral route

Last Answer : B. It suppresses postoperative nausea and vomitin

Description : Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist

Last Answer : A. Selective AT1 receptor antagonist

Description : Choose the selective estrogen receptor modulator that is useful in dysfunctional uterine bleeding by acting as estrogen antagonist in endometrium, but does not alter vaginal epithelium or cervical mucus: A. Ormeloxifene B. Tamoxifen C. Centchroman D. Danazol

Last Answer : . Ormeloxifen

Description : The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level

Last Answer : C. It increases the incidence of myopathy due to statins

Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above

Last Answer : C. Leukotriene ( cys LT1) receptor antagonists

Description : Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation

Last Answer : Answer : C

Description : The distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile

Last Answer : C. It has additional androgenic acitivity

Description : he distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile

Last Answer : C. It has additional androgenic acitivity

Description : A. It is a clonidine congener used in spasticity due to stroke or spinal injury B. It reduces muscle tone by activating GABAB receptors C. It inhibits release of excitatory amino-acids in spinal interneurones D. It reduces muscle spasms without producing weaknes

Last Answer : B. It reduces muscle tone by activating GABAB receptors

Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Last Answer : C. Heparin is the physiologically active circulating anticoagulant

Description : Medicinal calcium salts are indicated for: A. Prevention of osteoporosis B. Hastening fracture union C. Peripheral neuritis D. All of the above

Last Answer : A. Prevention of osteoporosis

Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot

Description : The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn ... delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Last Answer : thrombin converts fibrinogen to fibrin

Description : Which of the following regarding thromboxane A2 is true? C A. It degrades basement membranes B. It is produced via the lipoxygenase pathway C. It stimulates platelet aggregation D. None of these

Last Answer : It stimulates platelet aggregation

Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor

Last Answer : B. Serotonin

Description : The following is true of linezolid except: A. It inhibits bacterial protein synthesis at an early step B. It is active against vancomycin resistant enterococci C. It is the drug of choice for enterococcal endocarditis D. It can be administered orally as well as by i.v. infusion

Last Answer : C. It is the drug of choice for enterococcal endocarditis

Description : The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases ... of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells

Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action

Description : The following is true of bupropion except: A. It inhibits dopamine reuptake along with inhibiting noradrenaline reuptake B. It produces sedation as a side effect C. It is being used as an aid for smoking cessation D. It is likely to produce seizures in overdose

Last Answer : B. It produces sedation as a side effect

Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures

Last Answer : D. It is not effective in generalized tonic-clonic seizures

Description : A 67-year-old male with advanced cholangiocarcinoma develops gram-negative sepsis. Excessive bleeding is noted around vascular catheters and from needle puncture sites. The diagnosis of disseminated ... b. Decreased fibrinogen level c. Normal prothrombin time d. Elevated fibrin split products

Last Answer : Answer: a, b, d Disseminated intravascular coagulation (DIC) is the primary form of acute thrombosis. Causes of this syndrome include abruptio placenta, gram-positive and gram-negative sepsis, ... decline in the platelet count and fibrinogen level, along with an elevation of fibrin split products