n addition to counteracting potassium loss, triamterene also opposes the following consequence of
thiazide/furosemide therapy:
A. Hyperuricaemia
B. Rise in plasma LDL-cholesterol
C. Magnesium loss
D. Both ‘A’ and ‘C’ are correct

1 Answer

Answer :

C. Magnesium loss

Related questions

Description : The most appropriate measure to overcome diminished responsiveness to furosemide after its longterm use is: A. Switching over to parenteral administration of furosemide B. Addition of a thiazide diuretic C. Addition of acetazolamide D. Potassium supplementation

Last Answer : B. Addition of a thiazide diuretic

Description : Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate

Last Answer : B. Calcium

Description : Metabolic actions of estrogens tend to cause the following except: A. Anabolism B. Impaired glucose tolerance C. Rise in plasma LDL-cholesterol D. Salt and water retention

Last Answer : C. Rise in plasma LDL-cholesterol

Description : Furosemide is to be preferred over hydrochlorothiazide when hypertension is accompanied by: A. Asthma B. Hyperuricaemia C. Diabetes D. Congestive heart failure

Last Answer : D. Congestive heart failure

Description : Specific drug therapy to lower serum triglycerides (TG) in a subject with normal LDL-cholesterol level is indicated: A. In all subjects with serum TG> 150 mg/dl B. In subjects with existing coronary artery disease and serum TG ... < 40 mg/dl and serum TG > 150 mg/dl D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

Description : Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently ... is likely to cause gut ulceration D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

Description : The following is true of bezafibrate except: A. It activates lipoprotein lipase B. It mainly lowers serum triglyceride level with smaller effect on LDL cholesterol level C. It increases the incidence of myopathy due to statins D. It tends to lower plasma fibrinogen level

Last Answer : C. It increases the incidence of myopathy due to statins

Description : Gemfibrozil has the following features except: A. It lowers plasma LDL cholesterol to a greater extent than triglycerides B. It tends to raise plasma HDL-cholesterol level C. It is a first ... type III, type IV and type V hyperlipoproteinemia D. It reduces the incidence of myocardial infarctio

Last Answer : A. It lowers plasma LDL cholesterol to a greater extent than triglycerides

Description : Long-term thiazide therapy can cause hyperglycaemia by: A. Reducing insulin release B. Interfering with glucose utilization in tissues C. Increasing sympathetic activity D. Increasing corticosteroid secretion

Last Answer : A. Reducing insulin release

Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class

Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately

Description : Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar leve

Last Answer : C. Fall in plasma free fatty acid level

Description : 17.5 Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar level

Last Answer : D. Rise in blood sugar level

Description : Use of potassium sparing diuretics in patients receiving the following drug needs close monitoring: A. Furosemide B. Hydrochlorothiazide C. Captopril D. Verapami

Last Answer : C. Captopril

Description : The following antihypertensive drug has a favourable effect on plasma lipid profile: A. Prazosin B. Propranolol C. Hydrochlorothiazide D. Furosemide

Last Answer : A. Prazosin

Description : Folinic acid is specifically indicated for: A. Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication B. Counteracting toxicity of high dose methotrexate C. Pernicious anaemia D. Anaemia associated with renal failure

Last Answer : C. Pernicious anaemia

Description : Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone

Last Answer : A. Lignocaine

Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above

Last Answer : D. All of the above

Description : Select the drug which reduces cholesterol synthesis in liver, increases expression of LDL receptors on hepatocytes and has been found to reduce mortality due to coronary artery disease: A. Simvastatin B. Nicotinic acid C. Gemfibrozil D. Colestipol (

Last Answer : A. Simvastatin

Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid

Last Answer : A. A HMG-CoA reductase inhibitor

Description : The following is true of simvastatin except: A. It is more potent than lovastatin B. At the highest recommended dose, it causes greater LDL-cholesterol lowering than lovastatin C. It does not undergo ... metabolism in liver D. It can raise HDL-cholesterol level when the same is low at base line

Last Answer : C. It does not undergo first pass metabolism in liver

Description : What is true of tamoxifen: A. It can induce endometrial proliferation in postmenopausal women B. It exerts antiestrogenic activity in bone C. It raises LDL-cholesterol levels D. It is ineffective in estrogen receptor-negative breast cancer

Last Answer : A. It can induce endometrial proliferation in postmenopausal women

Description : Hypothyroidism is a possible consequence of prolonged therapy with: A. Amiodarone B. Mexiletine C. Sotalol D. Procainamide

Last Answer : A. Amiodarone

Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct

Last Answer : D. Both 'A' and 'B' are correct

Description : Addition of pyrazinamide and ethambutol for the first two months to the isoniazid + rifampin therapy of tuberculosis serves the following purpose(s): A. Reduces the total duration of therapy to 6 months B. ... sputum conversion C. Permits reduction of rifampin dose D. Both A' and B' are correct

Last Answer : D. Both ‘A’ and ‘B’ are correc

Description : Addition of a progestin for 10-12 days every month to cyclic estrogen replacement therapy during menopause is recommended because the progestin: A. Prevents osteoporosis B. Prevents irregular bleeding C. Blocks increased risk of endometrial carcinoma D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal individual following a 12 hr fast? (A) Chylomicrons (B) VLDL (C) Both VLDL and LDL (D) LDL

Last Answer : Answer : D

Description : Choose the correct statement about thiazide diuretics: A. They act in the proximal convoluted tubule B. They are uricosuric C. They augment corticomedullary osmotic gradient D. They induce diuresis in acidosis as well as alkalosis

Last Answer : D. They induce diuresis in acidosis as well as alkalosis

Description : At equinatriuretic doses which diuretic causes the maximum K+ loss: A. Furosemide B. Hydrochlorothiazide C. Acetazolamide D. Amiloride

Last Answer : C. Acetazolamide

Description : Hyperuricaemia is produced by the following drugs except: A. Ethambutol B. Pyrazinamide C. Sulfinpyrazone D. Hydrochlorothiazide

Last Answer : C. Sulfinpyrazone

Description : Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III ... hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Description : Of the following diuretic medications, which conserves potassium? a) Spironolactone (Aldactone) Aldactone is known as a potassium-sparing diuretic. b) Furosemide (Lasix) Lasix causes loss of ... (Diuril) Diuril causes mild hypokalemia. d) Chlorthalidone (Hygroton) Hygroton causes mild hypokalemia.

Last Answer : a) Spironolactone (Aldactone) Aldactone is known as a potassium-sparing diuretic.

Description : Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in ... with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure

Last Answer : Answers-2 Hyperuricaemia may be due to increased purine intake, urate production or reduced urate clearance, and is most commonly due to the latter. Therefore it can occur in association with enhanced ... . Many of the uricosuric drugs may be detrimental in renal failure and may not be effective.

Description : Individual drugs of thiazide and related class of diuretics differ markedly from each other in the following respect? A. Diuretic efficacy B. Diuretic potency C. Side effects D. Propensity to cause hyperkalemia

Last Answer : B. Diuretic potency

Description : The primary site of action of thiazide diuretics is: A. Proximal tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts

Last Answer : C. Cortical diluting segment

Description : Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl- cotransport in the ascending limb of loop of Henle C ... in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

Description : Thiazide diuretics are the preferred first line antihypertensives for the following category of patients: A. Young hypertensives B. Physically and sexually active male hypertensives C. Elderly obese hypertensives D. Diabetic hypertensives

Last Answer : C. Elderly obese hypertensives

Description : As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost

Last Answer : A. High ceiling antihypertensive action

Description : Thiazide diuretics do not potentiate the antihypertensive action of one of the following drugs: A. Metoprolol B. Nifedipine C. Hydralazine D. Captopril

Last Answer : B. Nifedipine

Description : The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range ... has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients

Last Answer : B. The dose has to be titrated over a wide range according to the response

Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Description : hat is/are the consequence(s) of myocardial Na+ K+ ATPase inhibition by digoxin: A. Increased intracellular Na+ ion concentration B. Increased cytosolic Ca2+ ion concentration C. Increased intracellular K+ ion concentration D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Description : Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min ... accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles

Last Answer : B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy

Description : Which of the following drugs can afford both haemodynamic improvement as well as disease modifying benefits in CHF: A. Furosemide B. Milrinone C. Losartan D. Digoxin

Last Answer : C. Losartan

Description : Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial ... vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

Last Answer : The estrogen commonly used for hormone replacement therapy in menopausal women is: A. Ethinylestradiol B. Estradiol benzoate C. Diethylstilbestrol D. Conjugated estrogens

Description : A patient of iron deficiency anaemia has been put on iron therapy. What should be the rate of rise in haemoglobin level of blood so that response is considered adequate: A. 0.05 – 0.1 g% per week B. 0.1 – 0.2 g% per week C. 0.5 – 1.0 g% per week D. More than 1.0 g% per week

Last Answer : C. 0.5 – 1.0 g% per week

Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Last Answer : C. Heparin is the physiologically active circulating anticoagulant

Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL

Last Answer : Answer : D

Description : Which one of the following is lest likely to be useful in the therapy of hypercalcemia? (a) Calcitonin (b) Glucocorticoids (c) Plicamycin (d) Parenteral infusion of phosphate (e) Thiazide diuretics

Last Answer : Ans: E

Description : The following have a lower concentration in the cerebrospinal fluid (CSF) than plasma: a. glucose b. sodium c. potassium d. magnesium

Last Answer : magnesium

Description : Which is the principal cation in the plasma of the blood? (a) Potassium (b) Magnesium (c) Calcium (d) Sodium

Last Answer : d) Sodium