A patient with fungal encephalitis receiving amphotericin B
complaints of fever, chills, and body aches. The nurse knows that
these symptoms
a) may be controlled by the administration of diphenhydramine
(Benedryl) and acetaminophen (Tylenol) approximately 30 minutes
prior to administration of the amphotericin.
Administration of amphotericin B may cause fever, chills and body
aches. The administration of diphenhydramine (Benedryl) and
acetaminophen (Tylenol) approximately 30 minutes prior to the
administration of amphotericin B may prevent these side effects.
b) indicate renal toxicity and a worsening of the patient’s condition.
Renal toxicity due to amphotericin B is dose limiting. Monitoring the
serum creatinine and blood urea nitrogen levels may alert the nurse to
the development of renal insufficiency and the need to address the
patients’ renal status.
c) are primarily associated with infection with Coccidioides immitis and
Aspergillus.
Vascular changes are associated with C. immitis and Aspergillus
Manifestations of vascular change may include arteritis or cerebral
infarction.
d) indicate the need for immediate blood and cerebral spinal fluid (CSF)
cultures.
Blood and CSF cultures help diagnosis fungal encephalitis.

1 Answer

Answer :

a) may be controlled by the administration of diphenhydramine
(Benedryl) and acetaminophen (Tylenol) approximately 30 minutes
prior to administration of the amphotericin.
Administration of amphotericin B may cause fever, chills and body
aches. The administration of diphenhydramine (Benedryl) and
acetaminophen (Tylenol) approximately 30 minutes prior to the
administration of amphotericin B may prevent these side effects.

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