Description : The prostanoid that consistently constricts blood vessels is (a) Prostaglandin E2 (b) Prostaglandin F2a (c) Thromboxane A2 (d) Prostacyclin
Last Answer : Ans: C
Description : The prostanoid that consistently constricts blood vessels is: A. Prostaglandin E2 B. Prostaglandin F2α C. Thromboxane A2 D. Prostacyclin
Last Answer : C. Thromboxane
Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors
Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation
Description : The primary objective for designing drugs that selectively inhibit COX - 2 is to (a) Decrease the risk of nephrotoxicity (b) Improve anti-inflammatory effectiveness (c) Lower the ... of treatment of rheumatoid arthritis (e) Selectively decrease thromboxane A2 without effects on other eicosanoids
Description : A 60-year-old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure? (a) Leukotriene LTD4 or its analogs (b) Prostaglandin E2 or its analogs ( ... analogs (d) Slow-reacting substance of anaplylaxis (SRS-A) (e) Thromboxane A2 or its analogs
Description : Which of the following terms refers to leg pain that is brought on walking and caused by arterial insufficiency? a) Intermittent claudication Intermittent claudication is leg pain that is ... obliterans Thomroangitis obliterans is a peripheral vascular disease also known as Burger's disease.
Last Answer : a) Intermittent claudication Intermittent claudication is leg pain that is brought on by exercise and relieved by rest.
Description : From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase
Last Answer : Answer : A
Description : Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway ... effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells
Last Answer : Answer: d Inflammatory mediators have recently been recognized as playing a significant role in the clinical manifestations and progression of shock and the development ... increased pulmonary vascular resistance, bronchoconstriction, peripheral vasodilatation, and increased vascular permeability
Description : True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, ... prostaglandins have a short circulation half-life and exert most of their effects locally.
Last Answer : Answer: ABD DISCUSSION: The eicosanoids are a group of compounds arising from the metabolism of arachidonic acid. The prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase ... effects and may be involved in the physiologic responses associated with anaphylactic and septic shock
Description : The following are true about chemicals involved in allergic reaction: a. thromboxane -leukocyte activation b. prostaglandin-2 - vasodilatation c. platelet-activating factor - leukocyte activation d. heparin - augments inactivation of prostaglandins
Last Answer : prostaglandin-2 - vasodilatation
Description : Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts
Last Answer : B. Increased peristalsis of gut
Description : Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching
Last Answer : A. Dilatation of large blood vessels
Description : The following action of adrenaline is not mediated by β receptors: A. Dilatation of blood vessels B. Dilatation of pupil C. Bronchodilation D. Renin release from kidney
Last Answer : B. Dilatation of pupil
Description : The following prostanoid is a potent inducer of platelet aggregation (a) Prostacyclin (b) Prostaglandin E2 (c) Prostaglandin D2 (d) Thromboxane A2
Last Answer : Ans: D
Description : Which of the following eicosanoids is generated through the lipozygenase pathway ? (a) Prostaglandin E2 (b) Thromboxane A2 (c) Prostacyclin (d) Leukotriene C4
Description : Which of the following regarding thromboxane A2 is true? C A. It degrades basement membranes B. It is produced via the lipoxygenase pathway C. It stimulates platelet aggregation D. None of these
Last Answer : It stimulates platelet aggregation
Description : Thromboxane A2(TXA2): a. is derived from the membrane phospholipid b. its production is decreased by non-steroidal anti-inflammatory drugs c. causes platelet aggregation d. all above
Last Answer : all above
Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time
Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition
Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab
Last Answer : C. Dipyridamole
Description : Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets
Last Answer : D. Thromboxane A2 in platelets
Description : Ventricular remodeling after myocardial infarction involves the mediation of: A. Angiotensin II B. Prostaglandin C. Bradykinin D. Thromboxane A2
Last Answer : A. Angiotensin II
Description : Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension
Last Answer : A. Pregnancy induced hypertension
Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin
Last Answer : A. Thromboxane
Description : The following prostanoid is a potent inducer of platelet aggregation: A. Prostacyclin B. Prostaglandin E2 C. Prostaglandin D2 D. Thromboxane A2
Last Answer : D. Thromboxane A2
Description : The following eicosanoid is generated through the lipoxygenase pathway: A. Prostaglandin E2 B. Thromboxane A2 C. Leukotriene C4 D. Prostacyclin
Last Answer : C. Leukotriene C4
Description : Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) ... 2 (c) Glutathione - S - transferase (d) Lipoxygenase (e) Phospholipase A2
Last Answer : Ans: B
Description : Which of the following statement(s) is/are true concerning oxygen delivery? a. The amount of oxygen delivered to peripheral tissues is dependent upon the oxygen content in arterial blood and cardiac ... O2/dL d. Normal systemic oxygen delivery for a typical adult is approximately 1000 cc/min
Last Answer : Answer: a, c, d The amount of oxygen that is delivered to peripheral tissues is the product of the oxygen content in arterial blood times the cardiac output. Normally, oxygen content of arterial blood is ... of venous blood is 16 cc/dL. Hence, the normal arterial-venous difference is 4 cc O2/dL
Description : Which of the following statement(s) is/are true concerning O2 venous saturation monitoring? a. The normal saturation of mixed venous blood is 50% b. Mixed venous blood obtained ... than fully saturated blood, the difference between arterial and venous saturation corresponds to oxygen extraction
Last Answer : Answer: c, d The relationship between oxygen delivery and oxygen consumption is reflected in the amount of oxygen in venous blood. Under normal circumstances, oxygen delivery is 1000 ... and venous saturation corresponds to the oxygen extraction, hence the oxygen delivery/oxygen consumption ratio
Description : Relationship between arterial blood pressure (BP), cardiac outpur (CO) and peripheral vascular resistance (PVR) can be described as (a) BP = COxPVR (b) BP = CO/PVR (c) BP = PVR/CO (d) None of the above
Last Answer : Ans: A
Description : Which of the following terms refers to a muscular, cramp-like pain in the extremities consistently reproduced with the same degree of exercise and relieved by rest? a) Intermittent claudication Intermittent ... or dilated vessel. d) Ischemia Ischemia is a term used to denote deficient blood supply.
Last Answer : a) Intermittent claudication Intermittent claudication is a sign of peripheral arterial insufficiency.
Description : The following are true about dark adaptation: a. only regeneration of rhodopsin is responsible b. adaptation usually takes about 20 minutes c. dilatation of pupil plays a part in dark adaptation d. it is better with the fovea than the peripheral retina
Last Answer : dilatation of pupil plays a part in dark adaptation
Description : What are the blood vessels that carry venous blood to the heart? What is the blood vessel that collects arterial blood from the heart?
Last Answer : The blood vessels that debouch in the heart carrying venous blood are the inferior and the superior vena cava. The blood vessel that carries arterial blood from the heart is the aorta. Breathing Process Review - Image Diversity: vena cava aorta
Description : Stimulation of the beta receptors give rise to: a. tachycardia b. increased myocardial contraction c. vasoconstriction of visceral vessels d. pupil dilatation
Last Answer : increased myocardial contraction
Description : Thrombolytic therapy has become a useful adjunct in the management of peripheral arterial occlusion. In this setting, direct intraarterial administration rather than intravenous has been advocated ... may be indicated for situations where complete clot evacuation cannot be accomplished surgically
Last Answer : Answer: a, b, e The most popular method for intraarterial thrombolytic therapy for arterial occlusion involves passing a guidewire through the thrombus with arteriographic guidance and ... acute arterial occlusion) or when distal vasculative is occluded and precludes appropriate inflow patency
Description : What are arterial vessels, arteries and arterioles?
Last Answer : Arterial vessels are every blood vessel that carries blood from the heart to the tissues. Arteries and arterioles are arterial vessels. Arterioles are thin arteries that end in capillaries. Not ... to the lungs, contain venous blood. The Circulatory System - Image Diversity: arteries arterioles
Description : Which of the following terms refers to chest pain brought on by physical or emotional stress and relieved by rest or medication? a) angina pectoris Angina pectoris is a symptom of myocardial ischemia. ... d) ischemia Ischemia is insufficient tissue oxygenation and may occur in any part of the body.
Last Answer : a) angina pectoris Angina pectoris is a symptom of myocardial ischemia.
Description : The closed circulatory system is more efficient. Since blood circulates only inside blood vessels it can do it with more pressure reaching farther distances between the organs where hematosis ... exchange independently from the circulation) are generally slower and have a low metabolic rate.
Last Answer : What is the difference between octopuses and mussels regarding their circulatory systems?
Description : Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting ... through centrally mediated alpha-adrenergic stimulation in the brain, producing blood pressure reduction.
Last Answer : a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.
Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Description : Activation of endothelin receptor ETA, leads to (a) Vasoconstriction (b) Bronchoconstriction (c) Aldosterone release (d) All of the above
Description : Which of the following observations regarding ulcer formation on the patient's lower extremity indicate to the nurse that the ulcer is a result of venous insufficiency? a) The border of the ... d) The ulcer is deep, involving the joint space. Venous insufficiency ulcers are usually superficial.
Last Answer : a) The border of the ulcer is irregular. The border of an ulcer caused by arterial insufficiency is circular.
Description : Assertion`:` Atherosclerosis affects the vessels that supply blood to the heart muscle. Reason`:` It is caused by deposits of calcium, fat, chalestero
Last Answer : Assertion`:` Atherosclerosis affects the vessels that supply blood to the heart muscle. Reason`:` It is ... D. If both Assertion & Reason are false.
Description : The vascular lesions caused by leeches upon the blood vessels of their host cause blood naturally to coagulate. How does the leech solve this problem since it could be expected that the ingested blood would coagulate inside its body?
Last Answer : Ingested blood does not coagulate inside the leech (Hirudo medicinalis) because in its saliva there is a potent anticoagulant substance, a protein called hirudin. In the past leeches were ... in prevention against tissue necrosis after some surgeries and in several others fields of Medicine.
Description : Determinants of cerebral blood flow include: A. Preoperative neurologic dysfunction. B. Arterial CO 2 tension. C. Arterial O 2 tension. D. Systemic arterial pressure. E. All of the above.
Last Answer : Answer: BCD DISCUSSION: Determinants of cerebral blood flow include arterial CO 2 and O 2 tensions, systemic arterial pressure, and temperature. Other factors that may affect cerebral ... and intracranial pressure are head position, jugular venous obstruction, and positive end-expiratory pressure
Description : Rank the following laboratory tests and procedures in terms of their relative value to a 65-year-old woman who is to undergo elective resection of a sigmoid cancer. A. Carcinoembryonic antigen (CEA). B. ... Arterial blood oxygen tension (PaO 2) on room air. G. Serum sodium concentration (Na+).
Last Answer : Answer: CDFEBAG DISCUSSION: The most important test by far is the electrocardiogram, with its capacity to indicate signs of occult heart disease. The second most important evaluation is the hemoglobin ... for resection of the colon is always normal and would be of least value among these tests
Description : In the autonomic regulation of blood pressure (a) Cardiac output is maintained constant at the expense of other hemodynamic variables (b) Elevation of blood pressure results in elevated ... the sensitivity of the sensory baroreceptor nerve endings might cause an increase in sympathetic discharge
Description : 58 years old woman has presented with complaints of postmenopausal bleeding for the past two weeks. The most essential investigation would be: a) Colposcopy. b) Pap smear. c) Cone biopsy. d) D & C (dilatation & Curettage). e) Hysteroscopy
Last Answer : d) D & C (dilatation & Curettage).
Description : A 28 year old patient complains of amenorrhea after having dilatation and curettage. The most likely diagnosis is: a) Kallman’s Syndrome. b) Turner’s Syndrome. c) Asherman’s Syndrome. d) Pelvic inflammatory disease. e) Anorexia nervosa.
Last Answer : c) Asherman’s Syndrome.
Description : A 39 years old women Para 6 has presented with complaint of post coital bleeding for the past three months. Your first investigation should be: a) Dilatation & Curettage. b) Cone biopsy of cervix. c) Pap smear. d) Colposcopy. e) Laparoscopy.
Last Answer : c) Pap smear.