Description : Therapeutic dose of digoxin in a normal individual has the following effects, except (a) Increase in the speed of myocardial contractility (b) No significant change in cardiac output (c) Relaxation of peripheral vascular bed (d) Increase in the force of myocardial contractility
Last Answer : Ans: C
Description : When digoxin is used in a patient with congestive heart failure (CHF), it works by exerting a positive effect on (a) Stroke volume (b) Total peripheral resistance (c) Heart rate (d) Blood pressure (e) Venous return
Last Answer : Ans: A
Description : Which of the following drugs is believed to improve microcirculation in peripheral vascular diseases by promoting RBC flexibility ? (a) Cyclandelate (b) Theophyline (c) Pentoxiphyline (d) Nicotinic acid
Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Description : Which of the following statement(s) is/are true concerning oxygen delivery? a. The amount of oxygen delivered to peripheral tissues is dependent upon the oxygen content in arterial blood and cardiac ... O2/dL d. Normal systemic oxygen delivery for a typical adult is approximately 1000 cc/min
Last Answer : Answer: a, c, d The amount of oxygen that is delivered to peripheral tissues is the product of the oxygen content in arterial blood times the cardiac output. Normally, oxygen content of arterial blood is ... of venous blood is 16 cc/dL. Hence, the normal arterial-venous difference is 4 cc O2/dL
Description : The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is (a) Increase in total coronary blood flow (b) Redistribution of coronary blood flow (c) Reduction of cardiac preload (d) Reduction of cardiac after load
Description : Which of the following statement(s) is/are correct concerning the cardiovascular response to shock? a. Changes in cardiac contractile function shift the Frank Starling curve up and down b. ... d. The total circulating blood volume is equally split between the arterial and venous system
Last Answer : Answer: a Central in the general cardiovascular response to shock is the action of the heart itself. The principle determinants of cardiac function in the normal heart are the volume of blood ... Blood flow to the skin is sacrificed early, followed by that to the kidneys and splanchnic viscera
Description : Digoxin given for cardiac failure is extremely valuable in patients of (a) Thyrotoxicosis (b) Beriberi (c) Cor pulmonale (d) Atrial fibrillation
Last Answer : Ans: D
Description : Cardiac glycosides are obtained from following plant source. (a) Rauwolfia serpentina (b) Strophanthus gratus (c) Ricinus commounts. (d) Atropa belladonna
Last Answer : Ans: B
Description : In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above
Description : Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above
Description : Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues ... efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)
Description : The chief use of levoarterenol is to treat (a) Shock (b) Diabetes (c) Hypertension (d) Cardiac arrhythmias (e) Iron deficiencies
Description : The action of quinidine differs from that of digitalis in (a) Decreasing irritability of cardiac muscle (b) Preventing passage of impulses to the ventricle (c) Increasing irritability of heart muscle (d) Reducing conductivity (e) None of the above
Description : During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by (a) Delayed rectifier potassium current (b) outward chloride channel (c) Both (a) and (b) (d) None of the above
Description : Acute renal failure (ARF) may be caused by all of the following except (a) Acute tubular necrosis (ATN) due to drug therapy (e.g., aminoglycosides, contrast media) (b) Severe hypotension ... (c) Decreased cardiac output, as from congestive heart failure (d) Hemolysis, myoglobinuria (e) Hyperkalemia
Last Answer : Ans: E
Description : Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide
Description : The term ischemic heart disease (IHD) is used to designate all of the following conditions except (a) Angina pectoris (b) Sudden cardiac death (c) Congestive heart failur (CHF) (d) Arrhythmias
Description : Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin
Description : Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil
Description : Which of the following terms refers to leg pain that is brought on walking and caused by arterial insufficiency? a) Intermittent claudication Intermittent claudication is leg pain that is ... obliterans Thomroangitis obliterans is a peripheral vascular disease also known as Burger's disease.
Last Answer : a) Intermittent claudication Intermittent claudication is leg pain that is brought on by exercise and relieved by rest.
Description : Organic nitrates relax vascular smooth muscle by (a) Increasing intracellular cyclic AMP (b) Increasing intracellular cyclic GMP (c) Decreasing intracellular cyclic AMP (d) Both (b) and (c)
Description : Regarding verapamil, which one of the following statements is false? (a) Angina pectoris is an important indication for the use of verapamil (b) Contraindicated in the asthmatic patient (c) ... phase of the action potential in AV nodal cells (e) Used in management of supraventricular tachycardias
Description : Methylxanthine drugs such as aminophylline cause which one of the following? (a) Vasoconstriction in many vascular beds (b) Decrease in the amount of cAMP in mast cells (c) Bronchodilation (d) Activation of the enzyme phosphodiesterase (e) Sedation
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : Choose the correct statement about the action of nitrates on coronary vessels (a) They mitigate angina pectoris by increasing total coronary flow (b) They preferentially dilate conducting ... the larger arteries (d) They increase subepicardial blood flow without affecting subendocardial blood flow
Description : In the autonomic regulation of blood pressure (a) Cardiac output is maintained constant at the expense of other hemodynamic variables (b) Elevation of blood pressure results in elevated ... the sensitivity of the sensory baroreceptor nerve endings might cause an increase in sympathetic discharge
Description : Which stage of shock is best described as that stage when the mechanisms that regulate blood pressure fail to sustain a systolic pressure above 90 mm Hg? a) Progressive In the progressive stage of ... which organ damage is so severe that the patient does not respond to treatment and cannot survive.
Last Answer : a) Progressive In the progressive stage of shock, the mechanisms that regulate blood pressure can no longer compensate, and the mean arterial pressure falls below normal limits.
Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion
Description : Which of the following statement(s) is/are true concerning O2 venous saturation monitoring? a. The normal saturation of mixed venous blood is 50% b. Mixed venous blood obtained ... than fully saturated blood, the difference between arterial and venous saturation corresponds to oxygen extraction
Last Answer : Answer: c, d The relationship between oxygen delivery and oxygen consumption is reflected in the amount of oxygen in venous blood. Under normal circumstances, oxygen delivery is 1000 ... and venous saturation corresponds to the oxygen extraction, hence the oxygen delivery/oxygen consumption ratio
Description : Dilatation of the peripheral arterial blood vessels can be caused by: a. thromboxane A2 b. adenosine diphosphate c. endothelin d. prostaglandins
Last Answer : prostaglandins
Description : Which of the following terms refers to a muscular, cramp-like pain in the extremities consistently reproduced with the same degree of exercise and relieved by rest? a) Intermittent claudication Intermittent ... or dilated vessel. d) Ischemia Ischemia is a term used to denote deficient blood supply.
Last Answer : a) Intermittent claudication Intermittent claudication is a sign of peripheral arterial insufficiency.
Description : Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate
Description : Which of the following is used to lower blood lipid levels? (a) Trimethadione (b) Clofibrate (c) Flucytosine (d) Coumarin (e) Propranolol
Description : Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol
Description : After being counseled about lifestyle and dietary changes, the patient was started on atorvastatin. During his treatment with atorvastatin, it is important to routinely monitor serum concentrations of (a) ... Alanine and aspartate aminotransferase (c) Platelets (d) Red blood cells (e) Uric acid
Description : Invasive hemodynamic monitoring using a Swan-Gantz catheter is essential in the optimal management of patients in shock or those suffering post-shock sequelae. Which of the following physiologic ... , increased SVR d. Neurogenic shock: Decreased PCWP, increased cardiac output, decreased SVR
Last Answer : Answer: a, c
Description : Which of the following statements about septic shock are true? A. A circulating myocardial depressant factor may account for the cardiac dysfunction sometimes seen with shock due to sepsis or ... animal studies that demonstrate a significant improvement in survival with the use of such agents.
Last Answer : Answer: AB DISCUSSION: Shock due to sepsis or SIRS frequently manifests as a hyperdynamic cardiovascular response, consisting of an elevated CI and a decreased SVR or SVRI. Occasionally, ... been encouraging thus far in human clinical trials, despite the promising results from many animal studies
Description : Angiotensin converting enzyme inhibitors reduce the following haemodynamic parameters in congestive heart failure except: A. Systemic vascular resistance B. Right atrial pressure C. Cardiac output D. Heart rate × pressure product
Last Answer : C. Cardiac output
Description : The antihypertensive action of calcium channel blockers is characterized by the following except: A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy B. Lack of central side effects C. No compromise of male sexual function D. Safety in peripheral vascular diseases
Last Answer : A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy
Description : Determinants of cerebral blood flow include: A. Preoperative neurologic dysfunction. B. Arterial CO 2 tension. C. Arterial O 2 tension. D. Systemic arterial pressure. E. All of the above.
Last Answer : Answer: BCD DISCUSSION: Determinants of cerebral blood flow include arterial CO 2 and O 2 tensions, systemic arterial pressure, and temperature. Other factors that may affect cerebral ... and intracranial pressure are head position, jugular venous obstruction, and positive end-expiratory pressure
Description : Morphine induced fall in blood pressure involves the following factors except: A. Direct cardiac depression B. Direct reduction of vascular tone C. Vasomotor centre depression D. Histamine release
Last Answer : A. Direct cardiac depression
Description : Thrombolytic therapy has become a useful adjunct in the management of peripheral arterial occlusion. In this setting, direct intraarterial administration rather than intravenous has been advocated ... may be indicated for situations where complete clot evacuation cannot be accomplished surgically
Last Answer : Answer: a, b, e The most popular method for intraarterial thrombolytic therapy for arterial occlusion involves passing a guidewire through the thrombus with arteriographic guidance and ... acute arterial occlusion) or when distal vasculative is occluded and precludes appropriate inflow patency
Description : Major lipid class present in chylomicrons is (a) Endogenous triglycerides (b) Cholesterol esters (c) Dietary triglycerides (d) All of the above
Description : Aspirin in small doses (50 to 150 mg per day) (a) Is of benefit in patients of unstable angina (b) Has thrombolytic action (c) PREFerentially inhibits prostacyclin synthetase enzyme (d) MAY Alleviate need for Verapamil in variant angina
Description : Following statement is true about lidocaine (a) Reduce the slope of Phase 4 (b) Threshold excitability is not altered (c) Action potential is not affected (d) All of the above
Description : The agent given sublingually in an acute attack of angina pectoris is (a) Glyceryl trinitrate (b) Amyl nitrite (c) Erythrital tetranitrate (d) Pentaerythritol tetranitrate
Description : Higher incidence of myocardial infarction and increased mortality has been noted with the use of the following antihypertensive drug (a) Nifedipine (b) Verapamil (c) Diltiazem (d) Lisinopril
Description : ‘Coronary steal phenomenon’ has been noted most frequently with (a) Glyceryl trinitrate (b) Dipyridamole (c) Propranolol (d) Diltiazem