What is the explanation for the effect of pH?

What is the explanation for the effect of pH?
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Answer :

The pH decides the charge on the amino acid residues at the active site. The net charge on the enzyme protein would influence substrate binding and catalytic activity.
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If all the enzymes, intermediates and cofactors of the citric acid cycle as well as an excess of the starting substrate acetylCoA are present and functional in an organelle free solution at the appropriate pH, which of the following factors of the citric acid cycle would prove to be rate limiting? (A) Molecular oxygen (B) Half life of enzyme (C) Turnover of intermediates (D) Reduction of cofactors

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The pH optima for salivary analyse is (A) 6.6–6.8 (B) 2.0–7.5 (C) 7.9 (D) 8.6

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The pH optima of most of the enzymes is (A) Between 2 and 4 (B) Between 5 and 9 (C) Between 8 and 12(D) Above 12

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Lipase can act only at pH: (A) 2.5–4 (B) 3.5–5 (C) 4 to 5 (D) 5–7

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This technique takes the advantage of the fact that each protein has different pH at which it is electrically neutral i.e., its isoelectric pH: (A) Isoelectric focussing (B) Immunoel Ectro Phoresis (C) Chromatography (D) HPLC

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