Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate
Last Answer : Answer : A
Description : All the following statements regarding ketone bodies are true except (A) They may result from starvation (B) They are formed in kidneys (C) They include acetoacetic acid and acetone (D) They may be excreted in urine
Last Answer : Answer : B
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Last Answer : Answer : C
Description : The probable metabolic defect in gents is (A) A defect in excretion of uric acid by kidney (B) An overproduction of pyrimidines (C) An overproduction of uric acid (D) Rise in calcium leading to deposition of calcium urate
Description : A 0.22 M solution of lactic acid (pKa 3.9) was found to contain 0.20 M in the dissociated form and 0.02 M undissociated form, the pH of the solution is (A) 2.9 (B) 3.3 (C) 4.9 (D) 5.4
Description : At a pH below the isoelectric point, an amino acid exists as (A) Cation (B) Anion (C) Zwitterion (D) Undissociated molecule
Description : Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid
Last Answer : Answer : D
Description : In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid
Description : Uric acid is the catabolic end product of (A) Porphyrine (B) Purines (C) Pyrimidines (D) Pyridoxine
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above
Last Answer : D. All of the above
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : Ammonia is excreted as ammonium salts during metabolic acidosis but the majority is excreted as (A) Phosphates (B) Creatine (C) Uric acid (D) Urea
Description : Purines: a. include guanine b. are metabolized to uric acid c. are mainly synthesized in the liver d. all above
Last Answer : all above
Description : Dietary purines are catabolised in (A) Liver (B) Kidneys (C) Intesitnal mucosa (D) All of these
Description : All of the following are properties of fluoride except: A. Crosses the placental barrier B. It deposits rapidly in bone C. It is excreted rapidly by kidneys D. It is bacteriostatic E. It produces extrinsic tooth stain
Last Answer : E. It produces extrinsic tooth stain
Description : Mechanism by which NH3 is removed from the kidneys is (A) Urea formation (B) Uric acid formation (C) Creatinine formation (D) None of these
Description : All of the following statements concerning an acute gouty arthritis attack are correct except (a) The diagonosis of gout is assured by a good therapeutic response to colchicines because no ... attack usually involves only one joint, most frequently the big toe (first metatarsophalangeal joint)
Last Answer : Ans: A
Description : Two examples in which the nitrogenous wastes are excreted from body in the form of uric acid are (a) birds and lizards (b) frogs and cartilaginous fish (c) insects and bony fish (d) mammals and molluscs.
Last Answer : (a) birds and lizards
Description : Which of the following is NOT a nitrogenous waste compound excreted by animals? a) urea b) ammonia c) uric acid d) pyridine
Last Answer : ANSWER: D -- PYRIDINE
Description : Which of the following statements about nucleic acid is most correct? (A) Both pentose nucleic acid and deoxypentose nucleic acid contain the same pyrimidines (B) Both pentose nucleic acid and deoxypentose ... (C) RNA contains cytosine and thymine (D) DNA and RNA are hydrolysed by weak alkali
Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive
Description : Select the option which shows correct matching of animal with its excretory organ and excretory product. Animal Excretory Excretory organ product (a) Labeo (Rohu) Nephridial Ammonia tubes (b) Salamander Kidneys Urea (c) Peacock Kidneys Urea (d) Housefly Renal tubules Uric acid
Last Answer : (b) Salamander Kidneys Urea
Description : All the following statements describing lipids are true except (A) They usually associate by covalent interactions (B) They are structurally components of membranes (C) They are an intracellular energy source (D) They are poorly soluble in H2O
Description : Assertion: Uric acid is produced by the metabolism of purine and pyrimidine. Reason: Uric acid has high toxicity and is soluble in water.
Last Answer : Assertion: Uric acid is produced by the metabolism of purine and pyrimidine. Reason: Uric acid has ... D. If both Assertion and Reason are false
Description : That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises ... . Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides
Last Answer : B. Methionine antagonises the action of sulfonamides
Description : Which gland regulates the amount of water excreted by the kidneys?
Last Answer : Pituitary gland
Description : In most mammals, except primates, uric acid is metabolized by (A) Oxidation to allantoin (B) Reduction to NH3 (C) Hydrolysis to allantoin (D) Hydrolysis to NH3
Description : All of the following can occur in LeschNyhan syndrome except (A) Gouty arthritis (B) Uric acid stones (C) Retarted growth (D) Self-mutiliating behaviour
Description : Non-protein nitrogenous substances in blood include all of the following except (A) Urea (B) Uric acid (C) Creatinine (D) Inositol
Description : The ‘rho’ (ρ) factor is involved (A) To increase the rate of RNA synthesis (B) In binding catabolite repressor to the promoter region (C) In proper termination of transcription (D) To allow proper initiation of transcriptide
Description : Lactose or its analogues act as positive regulators of lac operon by (A) Attaching to i gene and preventing its expression (B) Increasing the synthesis of catabolite gene activator protein (C) ... holoenzyme (D) Binding to repressor subunits so that the repressor cannot attach to the operator locus
Description : Binding of RNA polymerase holoenzyme to the promoter region of lac operon is facilitated by (A) Catabolite gene activator protein (CAP) (B) cAMP (C) CAP-cAMP complex (D) None of these
Description : The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these
Description : The catabolite repression is mediated by a catabolite gene activator protein (CAP) in conjunction with (A) AMP (B) GMP (C) cAMP (D) Cgmp
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Description : Maximum quantity of sodium is excreted through (A) Urine (B) Faeces (C) Sweat (D) None of these
Description : Glycine is not required for the formation of (A) Taurocholic acid (B) Creatine (C) Purines (D) Pyrimidines
Description : In the genetic disorder of cystinuria, the patient excretes large quantities of cystine in their urine and its low solubility causes crystalline cystine to precipitate as stones in kidneys. The remedy ... C) NaHCO3 prevents stone formation by hydrolysis of cystine to cysteine (D) None of these
Description : All the following statements about pepsin are correct except (A) It is smaller than pepsinogen (B) It is formed by the action of HCl on its precursor (C) Its optimum pH is 1.0–2.0 (D) It hydrolyses the C-terminal and N-terminal peptide bonds of proteins
Description : Benedict’s test is less likely to give weakly positive results with concentrated urine due to the action of (A) Urea (B) Uric acid (C) Ammonium salts (D) Phosphates
Last Answer : B
Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections
Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble
Description : The following are true about fluorescein sodium: a. it is 60% bound to the plasma protein b. it leaks out of the choriocapillaris readily c. is excreted mainly by the kidney d. it is excited by green light
Last Answer : is excreted mainly by the kidney
Description : Diethyl malonate reacts with urea in the presence of sodium ethoxide to form (a) Uric acid (b) Barbituric acid (c) Phenobarbital (d) Barbital
Last Answer : Barbituric acid
Description : Which of the following is not a constituent of normal urine? (a) Albumin (b) Urea (c) Sodium chloride (d) Uric acid
Last Answer : Albumin
Description : Which of the following statements about normal salt and water balance are true? A. The products of catabolism may be excreted by as little as 300 ml. of urine per day. B. The lungs represent ... of total body water. E. In normal humans, urine represents the greatest source of daily water loss.
Last Answer : Answer: CE DISCUSSION: The skin is the primary source of insensible water loss. Including losses from the lungs, this averages 600 to 900 ml. per day. Catabolism liberates water of solution. In ... still excrete a minimum of 500 to 800 ml. of urine per day to expel the products of catabolism
Description : Cholesterol is excreted as such into ________. (A) Urine (B) Faeces (C) Bile (D) Tears FATS AND FATTY ACID METABOLISM 99
Description : Glycerol released from adipose tissue by hydrolysis of triglycerides is mainly (A) Taken up by liver (B) Taken up by extrahepatic tissues (C) Reutilised in adipose tissue (D) Excreted from the body FATS AND FATTY ACID METABOLISM 85
Description : Normal quantity of urobilinogen excreted in the feces per day is about (A) 10–25 mg (B) 50–250 mg (C) 300–500 mg (D) 700–800 mg FATS AND FATTY ACID METABOLISM 79