Description : Transketolase activity is affected in (A) Bitoin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency
Last Answer : Answer : D
Description : Transketolase activity is affected in (A) Biotin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency
Last Answer : B
Last Answer : D) Thiamine deficiency
Description : Acute hemolytic episode after administration of antimalarial, primaquin, is due to deficiency of the enzyme: (A) 6-Phosphogluconate dehydrogenase (B) Glucose-6-phosphate dehydrogenase (C) Epimerase (D) Transketolase
Last Answer : Answer : B
Description : Acute hemolytic anemia in person’s sensitive to the Fava beans is due to the deficiency of the enzyme: (A) Pyruvate dehydrogenase (B) G-6-PD (C) Aconitase (D) Transketolase
Description : The transketolase enzyme in the pentose phosphate pathway requires the B vitamin. (A) Pantothenic acid (B) Thiamin (C) Riboflavin (D) Nicotinic acid
Description : Which of the following enzyme is not involved in HMP shunt? (A) Glyceraldehyde-3-p dehydrogenase (B) Glucose-6-p-dehydrogenase (C) Transketolase (D) Phosphogluconate dehydrogenase
Last Answer : A
Description : Transketolase has the coenzyme: (A) NAD+ (B) FP (C) TPP (D) Pyridoxol phosphate
Last Answer : C
Description : Abnormal transketolase leads to what clinical condition?
Last Answer : The occurrence of Wernickís encephalopathy (seen in alcoholics and in thiamine deficiency) is due to a genetic defect in the enzyme transketolase. It occurs owing to the enzyme having low binding capacity for TPP.
Description : What is the clinical significance of transketolase enzyme?
Last Answer : The transketolase reaction is measured in RBCs as an index of the thiamine status of an individual.
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : An increased serum ‘Iron’ and decreased ‘Fe’ binding capacity are found in (A) Fe-deficiency anaemia (B) Sideroblastic anaemia (C) Thalassaemia (D) Anaemia of chromic disorders
Description : An increased serum iron and decreased iron binding capacity is found in (A) Fe deficiency anemia (B) Sideroblastic anemia (C) Folate deficiency anemia (D) Sickle cell anemia
Description : Deficiency of vitamin B12 can occur because of (A) Decreased intake of vitamin B12 (B) Atrophy of gastric mucosa (C) Intestinal malabsorption (D) All of these
Description : The absorption of glucose is decreased by the deficiency of (A) Vitamin A (B) Vitamin D (C) Thiamine (D) Vitamin B12
Last Answer : Answer : C
Description : Which one of the following would be expected in pyruvate kinase deficiency? (A) Increased levels of lactate in the R.B.C (B) Hemolytic anemia (C) Decreased ratio of ADP to ATP in R.B.C (D) Increased phosphorylation of Glucose to Glucose-6-phosphate
Description : All the following statements about ceruloplasmin are correct except (A) It is a copper-containing protein (B) It possesses oxidase activity (C) It is synthesised in intestinal mucosa (D) Its plasma level is decreased inWilson’s disease
Description : In competitive enzyme activity inhibition (A) Apparent Km is decreased (B) Apparent Km is increased (C) Vmax is increased (D) Vmax is decreased
Description : In reversible non-competitive enzyme activity inhibition (A) Inhibitor bears structural resemblance to substrate (B) Inhibitor lowers the maximum velocity attainable with a given amount of enzyme (C) Km is increased (D) Km is decreased
Description : In reversible non-competitive enzyme activity inhibition (A) Vmax is increased (B) Km is increased (C) Km is decreased (D) Concentration of active enzyme is reduced
Description : A deficiency of copper effects the formation of normal collagen by reducing the activity of which of the following enzyme? (A) Prolyl hydroxylase (B) Lysyl oxidase (C) Lysyl hydroxylase (D) Glucosyl transferase
Description : The deficiency of copper decreases the activity of the enzyme: (A) Lysine oxidase (B) Lysine hydroxylase (C) Tyrosine oxidase (D) Proline hydroxylase
Last Answer : Answer : A
Description : Dietary deficiency of thiamin inhibits the activity of the enzyme: (A) Pyruvate kinase (B) Pyruvate dehydrogenase (C) Phosphofructokinase (D) Enolase
Description : Which one of the following statements concerning glucose-6-phosphate dehydrogenase deficiency is correct? (A) Young R.B.Cs, particularly reticulocytes, contain the highest enzyme activity cells show less enzyme ... PD gene (D) G-6-PD deficiency is precipitated by ingestion of drugs such as aspirin
Description : The “Primaquin sensitivity types of haemolytic anaemia has been found to relate to reduced R.B.C activity of which enzyme? (A) Pyruvate kinase deficiency (B) Glucose-6-phosphatase deficiency (C) Glucose-6-p dehydrogenase deficiency (D) Hexokinase deficiency
Description : In iron deficiency anaemia, the following is decreased: a. MCV (mean cell volume) b. ferritin c. MCH (mean cell haemoglobin) d. all above
Last Answer : all above
Description : Von Willebrand disease is, A. Haemophilic disease B. Bacterial Endocarditis C. Congenital cardiac disease D. Rheumatic fever Decreased PTT, bleeding time prolonged, deficiency factor VIII
Last Answer : A. Haemophilic disease
Description : Which of the following statement(s) is/are true concerning the various types of shock? a. Traumatic shock is more commonly associated with subsequent organ injury and multiorgan failure ... responds quickly to resuscitation e. Neurogenic shock occurs with the absence of sympathetic activity
Last Answer : Answer: a, b, d, e Classification schemes of shock based on cause have been developed for the seemingly dissimilar processes leading to circulatory collapse and the shock state. ... and pressor agents. The response to exogenous corticosteroids is usually dramatic and potentially life-saving
Description : The primary mechanism underlying the resistance of gram-positive organisms to macrolide antibiotics is (a) Methylation of binding sites on the 50S ribosomal subunit (b) Formation of ... ) Formation of drug-inactivating acetyltranferases (e) Decreased drug permeability of the cytoplasmic membrane
Last Answer : Ans: A
Description : At the adrenergic synapse, the concentration of adrenaline in synaptic cleft: a. increased by cocaine which inhibit reuptake of adrenaline b. decreased by MAO (monoamine oxidase) - inhibitors c. controlled chiefly by the activity of the enzyme COMT d. increased by noradrenaline receptor blockers
Last Answer : increased by cocaine which inhibit reuptake of adrenaline
Description : Which of the following statements reflects nursing care of the woman with mild to moderate ovarian hyperstimulation syndrome (OHSS)? a) Advise the patient to decrease her activity, monitor ... for immediate hospitalization. The patient with severe OHSS is hospitalized for monitoring and treatment.
Last Answer : a) Advise the patient to decrease her activity, monitor her urine output and to return for frequent office visits. Management in mild and moderate cases of OHSS consists of decreased activity, monitoring of urine output and frequent office visits as designated by the reproductive endocrinologist.
Description : When assessing the older adult, the nurse anticipates increase in which of the follow components of respiratory status? a) Residual lung volume As a result, patient experience fatigue ... ) Cough efficiency The nurse anticipates difficulty coughing up secretions due to decreased cough efficiency.
Last Answer : a) Residual lung volume As a result, patient experience fatigue and breathlessness with sustained activity.
Description : Which of the following is true in regard to smoking, A. Smokers keratosis is common but metaplasia activity is not recognised B. Redox potential is increased resulting in aerobic bacteria C. Tissue perfusion is decreased resulting in increased infection
Last Answer : A. Smokers keratosis is common but metaplasia activity is not recognised
Description : Molybdenum deficiency affects the activity of – (1) All of the given options (2) Chlorate reductase (3) Nitrogenase (4) Nitrate reductase
Last Answer : (4) Nitrate reductase Explanation: Numerous investigators have shown that nitrate nitrogen accumulates in higher plants and fungi which are deficient in molybdenum. In molybdenum-deficient plants grown in the ... in the decrease of free amino acids in the plants in comparison to normal plants.
Description : Molybdenum deficiency affects the activity of : (1) All of the given options (2) Chlorate reductase (3) Nitrogenase (4) Nitrate reductase
Last Answer : Nitrate reductase
Description : Blood chemistry shows the following changes in compensated respiratory acidosis: (A) Increased pCO2 (B) Increased bicarbonate (C) Decreased chloride (D) All of these
Description : During compensation of respiratory alkalosis, all the following changes occur except (A) Decreased secretion of hydrogen ions by renal tubules (B) Increased excretion of sodium in urine (C) Increased excretion of bicarbonate in urine (D) Increased excretion of ammonia in urine
Description : All the following changes in blood chemistry can occur in severe diarrhoea except (A) Decreased pH (B) Decreased bicarbonate (C) Increased pCO2 (D) Increased chloride WATER AND ELECTROLYTE BALANCE 287
Description : All the following statements about renal tubular acidosis are correct except (A) Renal tubules may be unable to reabsorb bicarbonate (B) Renal tubules may be unable to secrete hydrogen ions (C) Plasma chloride is elevated (D) Anion gap is decreased
Description : All the following features are found in blood chemistry in uncompensated lactic acidosis except (A) pH is decreased (B) Bicarbonate is decreased (C) pCO2 is normal (D) Anion gap is normal
Description : Diabetes insipidus results from (A) Decreased insulin secretion (B) Decreased ADH secretion (C) Decreased aldosterone secretion (D) Unresponsiveness of osmoreceptors
Description : Oedema can occur when (A) Plasma Na and Cl are decreased (B) Plasma Na and Cl are increased (C) Plasma proteins are decreased (D) Plasma proteins are increased
Description : The oxygen d issoc iat ion curve for hemoglobin is shifted to the right by (A) Decreased O2 tension (B) Decreased CO2 tension (C) Increased CO2 tension (D) Increased pH
Description : Mutations in promoter regions of genes can cause (A) Premature termination of translation (B) Change in reading frame of downstream structural gene (C) Decreased efficiency of transcription (D) All of these
Description : All of the following occur in orotic aciduria except (A) Increased synthesis of pyrimidine nucleotides (B) Increased excretion of orotic acid in urine (C) Decreased synthesis of cytidine triphosphate (D) Retardation of growth
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate
Description : Which of the following is noted in cushing’s syndrome, a tumor associated disease of the adrenal cortex? (A) Decreased production of epinephrine (B) Excessive production of epinephrine (C) Excessive production of vasopressin (D) Excessive production of cortisol
Description : Iodide uptake by thyroid gland is decreased by (A) Thicyanate (B) Thiouracil (C) Thiourea (D) Methimazole
Description : Women become susceptible to osteoporosis after menopause due to decreased (A) Secretion of Parathormone (B) Conversion of vitamin D into calcitriol (C) Secretion of estrogen (D) Secretion of progesterone